PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla020243
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family AP2
Protein Properties Length: 501aa    MW: 55741.6 Da    PI: 5.2508
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla020243genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP254.13.9e-17141190155
        AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkkleg 55 
                s+y+GV++++++grW+++I+d      + k+++lg f+ta  Aa+a+++a+ k++g
  Cla020243 141 SQYRGVTFYRRTGRWESHIWD------CgKQVYLGGFDTAHAAARAYDRAAIKFRG 190
                78*******************......55************************998 PP

2AP228.44e-09233273145
        AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAaka 45 
                s+++GV+ +k  grW+A+   +     +k+++lg f+++ eAa++
  Cla020243 233 SKFRGVTLHK-CGRWEARMGQF--L-GKKYVYLGLFDSEIEAARL 273
                79********.7******5553..2.26**********99***97 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541716.28E-16141199IPR016177DNA-binding domain
PfamPF008472.9E-9141190IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.5E-17142198IPR001471AP2/ERF domain
SMARTSM003801.9E-32142204IPR001471AP2/ERF domain
PROSITE profilePS5103217.754142198IPR001471AP2/ERF domain
CDDcd000186.28E-12142197No hitNo description
SuperFamilySSF541711.37E-10233308IPR016177DNA-binding domain
CDDcd000181.05E-20233308No hitNo description
PfamPF008473.4E-5233273IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.104.8E-8234306IPR001471AP2/ERF domain
SMARTSM003809.8E-22234312IPR001471AP2/ERF domain
PROSITE profilePS510328.729234275IPR001471AP2/ERF domain
PRINTSPR003671.5E-5235246IPR001471AP2/ERF domain
PRINTSPR003671.5E-5288308IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 501 aa     Download sequence    Send to blast
MWDLNDSPDY GGTDEFEVLS SIDGDEDRAK WIGSINSNSS SSVVVMEDGS DADEASVGED  60
EPLVHRKNFS VTHPLATRQF FPLEDSDVGA SSAAVGGSAT FPRARWVGVK FCQTEPVAAV  120
RPMAVLQPIK KSRRGPRSRS SQYRGVTFYR RTGRWESHIW DCGKQVYLGG FDTAHAAARA  180
YDRAAIKFRG SEADINFSIE DYEEDLQQMG NLTKEEFVHV LRRQSTGYPR GTSKFRGVTL  240
HKCGRWEARM GQFLGKKYVY LGLFDSEIEA ARLPDYELQL VSATCFRAYD KAAIKCNGKE  300
AVTNFDPSIY EDELSTTESS SAKVWEQNLD LRLGNSSSKS HTLSFGNHCP NVTPNIDLQI  360
TNESNPQESN IFENDNGGSC TFLQTEKMQF RSEMIVRSPP SVEMMKHGRL ETPMELQTLH  420
NYSPQINQSN SQIQLLSSSN EGGLGSDELS LCLSEGHQWQ QSGGSQQFAN AAASSGFPQL  480
QISTSQNWLQ KNNGCFLQRP S
Functional Description ? help Back to Top
Source Description
UniProtProbable transcriptional activator that promotes early floral meristem identity (PubMed:7919989). Is required subsequently for the transition of an inflorescence meristem into a floral meristem (PubMed:1675158). Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes (PubMed:1675158, PubMed:23034631). Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and SEUSS (PubMed:1675158). Directly represses AGAMOUS by recruiting the transcriptional corepressor TOPLESS and the histone deacetylase HDA19 (PubMed:23034631). It is also required during seed development (PubMed:1675158). {ECO:0000269|PubMed:1675158, ECO:0000269|PubMed:23034631, ECO:0000269|PubMed:7919989}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Negatively regulated by the C class floral homeotic protein AGAMOUS in stamens and carpels. MicroRNA 172 (miRNA172) negatively regulates APETALA2 at the translational level and may modulate its expression pattern. Seems not to be influenced by jasmonate and Alternaria brassicicola. {ECO:0000269|PubMed:12805630, ECO:0000269|PubMed:12893888, ECO:0000269|PubMed:14555699}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6819131e-169LN681913.1 Cucumis melo genomic scaffold, anchoredscaffold00045.
GenBankLN7132651e-169LN713265.1 Cucumis melo genomic chromosome, chr_11.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008457743.10.0PREDICTED: AP2-like ethylene-responsive transcription factor TOE3 isoform X1
RefseqXP_008457744.10.0PREDICTED: AP2-like ethylene-responsive transcription factor TOE3 isoform X1
SwissprotP479271e-115AP2_ARATH; Floral homeotic protein APETALA 2
TrEMBLA0A1S3C6760.0A0A1S3C676_CUCME; AP2-like ethylene-responsive transcription factor TOE3 isoform X1
STRINGXP_008457743.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF37843463
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G36920.21e-109AP2 family protein
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Thamilarasan SK,Park JI,Jung HJ,Nou IS
    Genome-wide analysis of the distribution of AP2/ERF transcription factors reveals duplication and CBFs genes elucidate their potential function in Brassica oleracea.
    BMC Genomics, 2014. 15: p. 422
    [PMID:24888752]
  3. Zhang GB,Yi HY,Gong JM
    The Arabidopsis ethylene/jasmonic acid-NRT signaling module coordinates nitrate reallocation and the trade-off between growth and environmental adaptation.
    Plant Cell, 2014. 26(10): p. 3984-98
    [PMID:25326291]
  4. Ranocha P,Francoz E,Burlat V,Dunand C
    Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion.
    Plant Signal Behav, 2014. 9(11): p. e977734
    [PMID:25531128]
  5. Djemal R,Khoudi H
    Isolation and molecular characterization of a novel WIN1/SHN1 ethylene-responsive transcription factor TdSHN1 from durum wheat (Triticum turgidum. L. subsp. durum).
    Protoplasma, 2015. 252(6): p. 1461-73
    [PMID:25687296]
  6. Kazan K
    Diverse roles of jasmonates and ethylene in abiotic stress tolerance.
    Trends Plant Sci., 2015. 20(4): p. 219-29
    [PMID:25731753]
  7. Prunet N, et al.
    SQUINT promotes stem cell homeostasis and floral meristem termination in Arabidopsis through APETALA2 and CLAVATA signalling.
    J. Exp. Bot., 2015. 66(21): p. 6905-16
    [PMID:26269626]
  8. Xie W, et al.
    Exploring potential new floral organ morphogenesis genes of Arabidopsis thaliana using systems biology approach.
    Front Plant Sci, 2015. 6: p. 829
    [PMID:26528302]
  9. Zumajo-Cardona C,Pabón-Mora N
    Evolution of the APETALA2 Gene Lineage in Seed Plants.
    Mol. Biol. Evol., 2016. 33(7): p. 1818-32
    [PMID:27030733]
  10. Zhao Y, et al.
    An alternative strategy for targeted gene replacement in plants using a dual-sgRNA/Cas9 design.
    Sci Rep, 2016. 6: p. 23890
    [PMID:27033976]
  11. Gao R,Liu P,Irwanto N,Loh R,Wong SM
    Upregulation of LINC-AP2 is negatively correlated with AP2 gene expression with Turnip crinkle virus infection in Arabidopsis thaliana.
    Plant Cell Rep., 2016. 35(11): p. 2257-2267
    [PMID:27473526]
  12. Huang Z, et al.
    APETALA2 antagonizes the transcriptional activity of AGAMOUS in regulating floral stem cells in Arabidopsis thaliana.
    New Phytol., 2017. 215(3): p. 1197-1209
    [PMID:27604611]
  13. Dory M, et al.
    Kinase-Associated Phosphoisoform Assay: a novel candidate-based method to detect specific kinase-substrate phosphorylation interactions in vivo.
    BMC Plant Biol., 2016. 16(1): p. 204
    [PMID:27655033]
  14. Wang P, et al.
    Expansion and Functional Divergence of AP2 Group Genes in Spermatophytes Determined by Molecular Evolution and Arabidopsis Mutant Analysis.
    Front Plant Sci, 2016. 7: p. 1383
    [PMID:27703459]
  15. Sharma P, et al.
    Promoter Trapping and Deletion Analysis Show Arabidopsis thaliana APETALA2 Gene Promoter Is Bidirectional and Functions as a Pollen- and Ovule-Specific Promoter in the Reverse Orientation.
    Appl. Biochem. Biotechnol., 2017. 182(4): p. 1591-1604
    [PMID:28130768]
  16. Kihira M, et al.
    Arabidopsis thaliana FLO2 is Involved in Efficiency of Photoassimilate Translocation, Which is Associated with Leaf Growth and Aging, Yield of Seeds and Seed Quality.
    Plant Cell Physiol., 2017. 58(3): p. 440-450
    [PMID:28158741]
  17. Balanzà V, et al.
    Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway.
    Nat Commun, 2018. 9(1): p. 565
    [PMID:29422669]
  18. Dotto M,Gómez MS,Soto MS,Casati P
    UV-B radiation delays flowering time through changes in the PRC2 complex activity and miR156 levels in Arabidopsis thaliana.
    Plant Cell Environ., 2018. 41(6): p. 1394-1406
    [PMID:29447428]
  19. Song C,Lee J,Kim T,Hong JC,Lim CO
    VOZ1, a transcriptional repressor of DREB2C, mediates heat stress responses in Arabidopsis.
    Planta, 2018. 247(6): p. 1439-1448
    [PMID:29536220]