PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla014051
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family AP2
Protein Properties Length: 599aa    MW: 65917.1 Da    PI: 7.9421
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla014051genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP235.82.1e-11292345152
        AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng.krkrfslgkfgtaeeAakaaiaarkk 52 
                s+y+GV++++++gr++A+++d  ++  g  rk  + g ++ +e+Aa+a++ a++k
  Cla014051 292 SQYRGVTRHRWTGRYEAHLWDnSCKkEGqSRKGRQ-GGYDMEEKAARAYDLAALK 345
                78*******************87776664446655.77**************987 PP

2AP232.62e-10372415955
        AP2   9 dkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                +++ grW A+I  +     +k  +lg+f t eeAa+a++ a+ k++g
  Cla014051 372 HHQHGRWQARIGRVAG---NKDLYLGTFSTQEEAAEAYDIAAIKFRG 415
                566889****988532...5************************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008473.2E-8292345IPR001471AP2/ERF domain
SuperFamilySSF541711.63E-9292348IPR016177DNA-binding domain
CDDcd000181.68E-13292345No hitNo description
SMARTSM003805.8E-7293349IPR001471AP2/ERF domain
PROSITE profilePS5103213.617293345IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.7E-7293345IPR001471AP2/ERF domain
PRINTSPR003673.3E-6294305IPR001471AP2/ERF domain
CDDcd000185.49E-23355425No hitNo description
SMARTSM003801.4E-28356429IPR001471AP2/ERF domain
PROSITE profilePS5103217.912356423IPR001471AP2/ERF domain
PfamPF008471.8E-5372415IPR001471AP2/ERF domain
SuperFamilySSF541712.55E-14372424IPR016177DNA-binding domain
Gene3DG3DSA:3.30.730.101.1E-14373423IPR001471AP2/ERF domain
PRINTSPR003673.3E-6405425IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 599 aa     Download sequence    Send to blast
MNNVNGNNCN WLGFSVSPNV NMELSSSSAT TVSPSIPANL FHSSSQFNYG ICYGVDAEHG  60
GFYSPLSAMP LKSDGSICSM EALSRQHPQV VSSSTPKLED FFGGATMGSH HYESNDREAM  120
ALSLDSIFCH QNPTHEPNNQ TFAHFSSLRS RELMLQDSKV ILPDGCNLQQ QQQHHPAVAQ  180
SDISSMKNWA VPRNYAATNN GSFEQKMVNC MTENSGESGP INAMAYGDLQ SLSLSMTMSP  240
SSQSSCVTTT QHVSPAMADC SAMDTKKRGH EKVDQKQIVH RKSLDTFGQR TSQYRGVTRH  300
RWTGRYEAHL WDNSCKKEGQ SRKGRQGGYD MEEKAARAYD LAALKRSSGF SRGASIYRGV  360
TRSNKSQFKA LHHQHGRWQA RIGRVAGNKD LYLGTFSTQE EAAEAYDIAA IKFRGMNAVT  420
NFDITRYDVE RIIASNTLLS GDLAKRKQQP EFDNESLRRS PTHNSNSEAM PLPSQNSSQS  480
ESDWKMALYQ SSQQLVPKQR MLSAINDDGS QIGVEDSARM GAHFSNASSM VTSCSLSSSR  540
EESPDKTSLS MVFGMPQSTS KPFAASASNM NTSWIASAQQ LRAANCMSQL PVFAAWTDT
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818750.0LN681875.1 Cucumis melo genomic scaffold, anchoredscaffold00007.
GenBankLN7132620.0LN713262.1 Cucumis melo genomic chromosome, chr_8.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011657909.10.0PREDICTED: AP2-like ethylene-responsive transcription factor ANT isoform X1
SwissprotQ389141e-132ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLA0A1S3B1520.0A0A1S3B152_CUCME; AP2-like ethylene-responsive transcription factor ANT isoform X1
STRINGXP_008440434.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF91634114
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G37750.11e-91AP2 family protein
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  3. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  4. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  5. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  6. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  7. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  8. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  9. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  10. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  11. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]