PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla009964
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family AP2
Protein Properties Length: 484aa    MW: 54592.6 Da    PI: 8.5175
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla009964genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP239.61.3e-12241297155
        AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng.krkrfslgkfgtaeeAakaaiaarkkleg 55 
                s+y+GV++++++gr++A+++d  ++  g  rk  + g ++ +e+Aa+a++ a++k++g
  Cla009964 241 SQYRGVTRHRWTGRYEAHLWDnSCKkEGqTRKGRQ-GGYDMEEKAARAYDLAALKYWG 297
                78*******************77776664346655.77******************98 PP

2AP251.13.3e-16340391155
        AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                s y+GV+++++ grW A+I  +     +k  +lg+fgt eeAa+a++ a+ k++g
  Cla009964 340 SIYRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFGTQEEAAEAYDIAAIKFRG 391
                57****************988532...5************************997 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541719.15E-15241306IPR016177DNA-binding domain
PfamPF008477.8E-10241297IPR001471AP2/ERF domain
CDDcd000181.18E-19241305No hitNo description
PROSITE profilePS5103217.49242305IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.104.2E-13242306IPR001471AP2/ERF domain
SMARTSM003802.1E-22242311IPR001471AP2/ERF domain
PRINTSPR003671.8E-6243254IPR001471AP2/ERF domain
PfamPF008475.0E-11340391IPR001471AP2/ERF domain
CDDcd000182.98E-25340401No hitNo description
SuperFamilySSF541711.77E-17340400IPR016177DNA-binding domain
PROSITE profilePS5103218.755341399IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.107.2E-18341400IPR001471AP2/ERF domain
SMARTSM003804.4E-33341405IPR001471AP2/ERF domain
PRINTSPR003671.8E-6381401IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007276Biological Processgamete generation
GO:0010492Biological Processmaintenance of shoot apical meristem identity
GO:0042127Biological Processregulation of cell proliferation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 484 aa     Download sequence    Send to blast
MAMEVTSESQ QHSHYHYHSQ ASSAGVVSNT MSNSFLASHH SNGDFYFSPL SVMPLKSDGS  60
LCIMESISAS QPQETLPNIS PKLEDFLGGA THGKEATTLS LDNIYYNQNN EVDSESQHSL  120
DLFKQQEQIH ILFHSQRYYS GLLQYPTEDP NKESHIASCY SEIQQDMEQR INGCCFGGMN  180
CQDLQPLSLS TSPSSQSSCV TAPSQISQPG PATMETKKRA FDNRKQSVHR KSIDTFGQRT  240
SQYRGVTRHR WTGRYEAHLW DNSCKKEGQT RKGRQGGYDM EEKAARAYDL AALKYWGPST  300
HLNFPLKNYQ LQIEEMKNMN RQEYVAHLRR KSNGFSRGAS IYRGVTRHHQ HGRWQARIGR  360
VAGNKDLYLG TFGTQEEAAE AYDIAAIKFR GVNAITNFDT SRYNVERIIA SSSLLSGEFA  420
RRNTEQKPTN TIKHKDPKQN IDKIDDPSKI SNNLDRKVVF NNNPILDPSA MVGSTDQKCM  480
KSSG
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00088SELEXTransfer from AT4G37750Download
Motif logo
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818611e-164LN681861.1 Cucumis melo genomic scaffold, anchoredscaffold00029.
GenBankLN7132611e-164LN713261.1 Cucumis melo genomic chromosome, chr_7.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008452679.10.0PREDICTED: AP2-like ethylene-responsive transcription factor AIL1 isoform X1
SwissprotQ389141e-144ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLA0A1S3BUF30.0A0A1S3BUF3_CUCME; AP2-like ethylene-responsive transcription factor AIL1 isoform X1
STRINGXP_008452679.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF91634114
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G37750.11e-136AP2 family protein
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  3. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  4. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  5. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  6. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  7. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  8. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  9. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  10. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  11. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]