PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cagra.11546s0003.1.p
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella
Family NAC
Protein Properties Length: 458aa    MW: 51395.9 Da    PI: 4.6411
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cagra.11546s0003.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM101.61.1e-31581921128
                   NAM   1 lppGfrFhPtdeelvveyLkkk.vegkk....leleevikevd....iykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratk. 79 
                           lp+G++F+P+d e++++ L+k+ ++g +    ++  e+i++v+    i++++P++Lp  vk++ +  +fF+k+ k+y+tg+rk+r+++ 
  Cagra.11546s0003.1.p  58 LPRGVKFDPSDPEIIWHLLAKSgLSGLSshpfID--EFIPTVNqddgICYTHPKNLP-GVKNDGTVSHFFHKAIKAYSTGTRKRRKIHd 143
                           799************9999988444444644422..33444433345**********.778888999******************8655 PP

                   NAM  80 ....sgyWkatgkdkevlskkgelvglkktLvfykgrapkgektdWvmheyrl 128
                               + +W++tg++k+v+  +g + g+kk++v+y g+a    kt+Wvmh+y+l
  Cagra.11546s0003.1.p 144 ddlgDVRWHKTGRTKPVVL-DGVQRGCKKIMVLYGGKAV---KTNWVMHQYHL 192
                           5655899************.99************76665...6********98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019411.03E-3743211IPR003441NAC domain
PROSITE profilePS5100531.15558211IPR003441NAC domain
PfamPF023651.5E-1259192IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000077Biological ProcessDNA damage checkpoint
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010332Biological Processresponse to gamma radiation
GO:0040020Biological Processregulation of meiotic nuclear division
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 458 aa     Download sequence    Send to blast
MAGRSWLIDS NRIATKIMSA SAGSDPRQVV WKSNPTRHCP NCRHVIDNSD VVDDWPGLPR  60
GVKFDPSDPE IIWHLLAKSG LSGLSSHPFI DEFIPTVNQD DGICYTHPKN LPGVKNDGTV  120
SHFFHKAIKA YSTGTRKRRK IHDDDLGDVR WHKTGRTKPV VLDGVQRGCK KIMVLYGGKA  180
VKTNWVMHQY HLGIEEDEKE GDYVVSKIFY QQPQQQVVKQ GDKAEQEVSE EIFAAMTPKA  240
DPVTPKLATP EPRHAVRLCS ASHIANDYVT PHSYVTAPEV SLAETSEVMY MEDEVQSIQP  300
NHERPSSADE PEPDPEPEHG LENGAEELID DKEEQDRDRD DEHQAEEEPT WFDSGSQFIL  360
NSQQLVEALS LCDDLLQVGS QDREENTNSG SLKNKQPCFA DYAHLGTEDF KRDLEECQKI  420
VLDPSNIELD TPPEFRLSQL EFGSQDSFLA WGTGKTD*
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269|PubMed:19549833, ECO:0000269|PubMed:20634150, ECO:0000269|PubMed:24399300, ECO:0000305|PubMed:24736489}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapCagra.11546s0003.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269|PubMed:23907539}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK2212660.0AK221266.1 Arabidopsis thaliana mRNA for hypothetical protein, complete cds, clone: RAFL24-13-I20.
GenBankAK2283160.0AK228316.1 Arabidopsis thaliana mRNA for hypothetical protein, complete cds, clone: RAFL14-74-M01.
GenBankBT0104500.0BT010450.1 Arabidopsis thaliana At1g25580 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006307460.10.0SUPPRESSOR OF GAMMA RESPONSE 1
SwissprotQ6NQK20.0NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBLR0ISL50.0R0ISL5_9BRAS; Uncharacterized protein
STRINGCagra.11546s0003.1.p0.0(Capsella grandiflora)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM97072736
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G25580.10.0NAC family protein
Publications ? help Back to Top
  1. Yi D, et al.
    The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species.
    Plant Cell, 2014. 26(1): p. 296-309
    [PMID:24399300]
  2. Biever JJ,Brinkman D,Gardner G
    UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation.
    J. Exp. Bot., 2014. 65(11): p. 2949-61
    [PMID:24591052]
  3. Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L
    Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links.
    Plant Cell, 2015. 27(1): p. 149-61
    [PMID:25595823]
  4. Chen P,Umeda M
    DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana.
    Genes Cells, 2015. 20(8): p. 636-46
    [PMID:26033196]
  5. Sjogren CA,Bolaris SC,Larsen PB
    Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response.
    Plant Cell, 2015. 27(9): p. 2501-15
    [PMID:26320227]
  6. Yoshiyama KO
    SOG1: a master regulator of the DNA damage response in plants.
    Genes Genet. Syst., 2016. 90(4): p. 209-16
    [PMID:26617076]
  7. Weimer AK, et al.
    The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.
    EMBO J., 2016. 35(19): p. 2068-2086
    [PMID:27497297]
  8. Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M
    DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana.
    Genes Cells, 2016. 21(11): p. 1195-1208
    [PMID:27658920]
  9. Pedroza-GarcĂ­a JA, et al.
    Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.
    Plant Physiol., 2017. 173(3): p. 1735-1749
    [PMID:28153919]
  10. Horvath BM, et al.
    Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control.
    EMBO J., 2017. 36(9): p. 1261-1278
    [PMID:28320736]
  11. Sjogren CA,Larsen PB
    SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis.
    Plant Cell Environ., 2017. 40(9): p. 1849-1860
    [PMID:28556304]
  12. Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S
    Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana.
    Plant Cell, 2017. 29(12): p. 3255-3268
    [PMID:29208704]
  13. Johnson RA, et al.
    SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration.
    Plant Physiol., 2018. 176(2): p. 1665-1675
    [PMID:29222192]
  14. Ogita N, et al.
    Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis.
    Plant J., 2018. 94(3): p. 439-453
    [PMID:29430765]
  15. Cao X, et al.
    Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots.
    Chemosphere, 2018. 201: p. 586-594
    [PMID:29533809]