PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cc06_g06370
Common NameGSCOC_T00031391001
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Coffeeae; Coffea
Family E2F/DP
Protein Properties Length: 468aa    MW: 51285.5 Da    PI: 4.7985
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cc06_g06370genomeCGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.96.4e-27145210171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Cc06_g06370 145 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 210
                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.5E-29142212IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.1E-17145208IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.4E-34145210IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.1E-24147210IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.27E-47221327No hitNo description
SuperFamilySSF1440743.66E-33224327No hitNo description
PfamPF164214.1E-32226325IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 468 aa     Download sequence    Send to blast
MSTPQAPSRG AAAGGRQIPQ PIKRHLPFSS MKPPFVPPED YHRFSTPAGA GTETVRIQDA  60
EAIVVKSPPI KRKSRTDNHE VSSTDWAASP GNTRTVSSPI CTPVSAKGGK AYGRSKVTKG  120
DMSGPSTPLS NAGSPAPLTP AGSCRYDSSL GLLTKKFINL IKHAEDGILD LNKAAETLEV  180
QKRRIYDITN VLEGIGLIEK KLKNRIHWKG LDASRPDEVE NDASILQAEV ENLSMEERRL  240
DDRIREMRER LRDLSEDEIN EKWLFVTEED IKTLPCFQNE TLIAIKAPHG TTLEVPDPDE  300
AVDYPQRRYR IILRSTMGPI DVYLVSQFEE KFEDVNGGEP SMRYALASSS GSNDNPAAET  360
AVYEKTGLVV GELAEQDTRM AADLDASHDY AGGMMKIVPS ENDADYWLLS DAGVSITDMW  420
KSDAGVEWNG VNMLHDEFGM SDISERPQTP PSGVVDMTYP AANATPR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-24140211274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027069049.10.0transcription factor E2FA isoform X3
RefseqXP_027176340.10.0transcription factor E2FA isoform X3
SwissprotQ9FNY01e-161E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A068UQU00.0A0A068UQU0_COFCA; Uncharacterized protein
STRINGVIT_08s0007g02510.t010.0(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-165E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]