PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID CA12g04370
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum
Family AP2
Protein Properties Length: 511aa    MW: 56364.3 Da    PI: 7.5584
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
CA12g04370genomePEPView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP227.58e-0970142155
         AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng..............kr..krfslgkfgtaeeAakaaiaarkkleg 55 
                 s y+GV++++++gr++A+++d  +   g              ++   ++++g ++ +e+Aa+a++ a++k++g
  CA12g04370  70 SIYRGVTRHRWTGRYEAHLWDnSCRrEGqtrkgrqvfmfvylMYfhLNVYIGGYDKEEKAARAYDLAALKYWG 142
                 57*******************7666733577789999987763367*************************98 PP

2AP247.35.3e-15185236155
         AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                 s y+GV+++++ grW A+I  +     +k  +lg+f t eeAa+a++ a+ k++g
  CA12g04370 185 SIYRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFSTQEEAAEAYDIAAIKFRG 236
                 57****************988532...5************************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008473.4E-670142IPR001471AP2/ERF domain
SuperFamilySSF541711.05E-1270152IPR016177DNA-binding domain
CDDcd000181.73E-1870152No hitNo description
SMARTSM003802.0E-2371156IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.103.9E-1371151IPR001471AP2/ERF domain
PROSITE profilePS5103217.17471150IPR001471AP2/ERF domain
PRINTSPR003677.2E-57283IPR001471AP2/ERF domain
PRINTSPR003677.2E-5132152IPR001471AP2/ERF domain
SuperFamilySSF541711.11E-17185245IPR016177DNA-binding domain
CDDcd000184.82E-25185246No hitNo description
PfamPF008476.6E-10185236IPR001471AP2/ERF domain
SMARTSM003802.7E-33186250IPR001471AP2/ERF domain
PROSITE profilePS5103219.177186244IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.104.8E-18186244IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 511 aa     Download sequence    Send to blast
MVVVGGGGNA QSLSLSMSTG GGGGENSCSS ENNKQEIVNG NNGSIIDGQI SGAIEVVPKK  60
SIDTFGQRTS IYRGVTRHRW TGRYEAHLWD NSCRREGQTR KGRQVFMFVY LMYFHLNVYI  120
GGYDKEEKAA RAYDLAALKY WGPTTTTNFP ISSYEKELEE MKHMTRQEYV ASLRRKSSGF  180
SRGASIYRGV TRHHQHGRWQ ARIGRVAGNK DLYLGTFSTQ EEAAEAYDIA AIKFRGLNAV  240
TNFEINRYDV KSILESSTLP IGGAAKRLKD VEQGEIALDY QRASQENIVN THLITSGSVG  300
SYGASHCWPN IALQQAQPLS AMHSYPYSQP RVWCKQEVQD SSDHLNVTSQ SYQDFHPLQL  360
GNGHNFMQTN SALHNLMGLD NSSMDHNSVA YHQGVGYASN GGNNHGVGFV LPHLSSIIPH  420
QESNHQQSQA NGYGENEVKQ LQLGNENLFG YYNSQQSTSN GSIKASLYDH QESTCNNWMS  480
TAVPVALASR SNTMAVCHGA APTFTVWNDT *
Functional Description ? help Back to Top
Source Description
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Master regulator of basal/root fate. Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis. Modulates the root polar auxin transport by regulating the distribution of PIN genes. Essential role in respecifying pattern and polarity in damaged roots. Direct target of the transcriptional corepressor TPL. Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs). {ECO:0000250, ECO:0000269|PubMed:15454085, ECO:0000269|PubMed:15635403, ECO:0000269|PubMed:16424342, ECO:0000269|PubMed:20190735}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin accumulation. {ECO:0000269|PubMed:15454085}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9754501e-77HG975450.1 Solanum pennellii chromosome ch11, complete genome.
GenBankHG9755231e-77HG975523.1 Solanum lycopersicum chromosome ch11, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016550816.10.0PREDICTED: AP2-like ethylene-responsive transcription factor AIL1 isoform X1
SwissprotQ5YGP71e-135PLET2_ARATH; AP2-like ethylene-responsive transcription factor PLT2
TrEMBLA0A2G3B0P70.0A0A2G3B0P7_CAPCH; AP2-like ethylene-responsive transcription factor BBM1
STRINGPGSC0003DMT4000418810.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA70992131
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G51190.11e-128AP2 family protein
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Lee DK,Sieburth LE
    The bps signal: embryonic arrest from an auxin-independent mechanism in bypass triple mutants.
    Plant Signal Behav, 2012. 7(6): p. 698-700
    [PMID:22580686]
  3. Hong LW,Yan DW,Liu WC,Chen HG,Lu YT
    TIME FOR COFFEE controls root meristem size by changes in auxin accumulation in Arabidopsis.
    J. Exp. Bot., 2014. 65(1): p. 275-86
    [PMID:24277277]
  4. Tian H,Jia Y,Niu T,Yu Q,Ding Z
    The key players of the primary root growth and development also function in lateral roots in Arabidopsis.
    Plant Cell Rep., 2014. 33(5): p. 745-53
    [PMID:24504658]
  5. Zhao Q, et al.
    Sulfur nutrient availability regulates root elongation by affecting root indole-3-acetic acid levels and the stem cell niche.
    J Integr Plant Biol, 2014. 56(12): p. 1151-63
    [PMID:24831283]
  6. Huang JB, et al.
    ROP3 GTPase contributes to polar auxin transport and auxin responses and is important for embryogenesis and seedling growth in Arabidopsis.
    Plant Cell, 2014. 26(9): p. 3501-18
    [PMID:25217509]
  7. Yang S, et al.
    The Arabidopsis SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA Targets Directly to PINs and Is Required for Root Stem Cell Niche Maintenance.
    Plant Cell, 2015. 27(6): p. 1670-80
    [PMID:25991732]
  8. Jia Y, et al.
    The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development.
    J. Exp. Bot., 2015. 66(15): p. 4631-42
    [PMID:25998905]
  9. Zhang M, et al.
    A tetratricopeptide repeat domain-containing protein SSR1 located in mitochondria is involved in root development and auxin polar transport in Arabidopsis.
    Plant J., 2015. 83(4): p. 582-99
    [PMID:26072661]
  10. Shinohara H,Mori A,Yasue N,Sumida K,Matsubayashi Y
    Identification of three LRR-RKs involved in perception of root meristem growth factor in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2016. 113(14): p. 3897-902
    [PMID:27001831]
  11. Ou Y, et al.
    RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana.
    Cell Res., 2016. 26(6): p. 686-98
    [PMID:27229312]
  12. Santuari L, et al.
    The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots.
    Plant Cell, 2016. 28(12): p. 2937-2951
    [PMID:27920338]
  13. Promchuea S,Zhu Y,Chen Z,Zhang J,Gong Z
    ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis .
    J Integr Plant Biol, 2017. 59(1): p. 30-43
    [PMID:28074634]
  14. Du Y,Scheres B
    PLETHORA transcription factors orchestrate de novo organ patterning during Arabidopsis lateral root outgrowth.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(44): p. 11709-11714
    [PMID:29078398]
  15. Bustillo-Avendaño E, et al.
    Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis.
    Plant Physiol., 2018. 176(2): p. 1709-1727
    [PMID:29233938]