PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID CA11g16440
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum
Family E2F/DP
Protein Properties Length: 402aa    MW: 44176.2 Da    PI: 4.3233
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
CA11g16440genomePEPView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.12.6e-2780145171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                 r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+i+wkg
  CA11g16440  80 RYDSSLGLLTKKFINLIKHAEDGMLDLNKAADTL---QV--QKRRIYDITNVLEGIGLIEKTLKNRIQWKG 145
                 6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.7E-2978147IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.6E-3480145IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467858.16E-1880143IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.4E-2482145IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.58E-49156262No hitNo description
SuperFamilySSF1440741.28E-33158262No hitNo description
PfamPF164211.4E-34161260IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 402 aa     Download sequence    Send to blast
MEALGPLKRK STATTCGQEV GDRNPVSGSA NVNSPMQTPM SGKDVQKVLR TSKAKSASQA  60
GNSNVGSPSG NDVTPAGPCR YDSSLGLLTK KFINLIKHAE DGMLDLNKAA DTLQVQKRRI  120
YDITNVLEGI GLIEKTLKNR IQWKGLDVSK PGEANESVAS LQAEVEKLTI KEHKLDDQIR  180
EMQERLRDLS EDENNQRWLF VTEDDIKSLP CFQNETLIAI KAPHGTTLEV PDPDEAVDYP  240
QRRYRIVLRS TMGPIDVYLV SQFEEKFEEV NAVEAPPSVP STSGLNENAT ATLDTEENRE  300
VDIVTEEKEN QSVRSDVGTS QDFMTGMMKI VPDVDNEADY WLLSDADVSI TDMWKTESAI  360
DWNELDVIQE DYSIANVSTP RAQTPPPSTA EVPSAGNTTG C*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-2675146274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0128400.0BT012840.1 Lycopersicon esculentum clone 113908F, mRNA sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016547862.10.0PREDICTED: transcription factor E2FB isoform X1
RefseqXP_016547863.10.0PREDICTED: transcription factor E2FB isoform X1
SwissprotQ9FV711e-148E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A2G2YH440.0A0A2G2YH44_CAPAN; Transcription factor E2FB
STRINGSolyc11g068800.1.10.0(Solanum lycopersicum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-150E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]