PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009138479.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family AP2
Protein Properties Length: 432aa    MW: 47924.8 Da    PI: 7.2811
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009138479.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP253.75.2e-17134183155
             AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkkleg 55 
                     s+y+GV++++++grW+++I+d      + k+++lg f+ta  Aa+a+++a+ k++g
  XP_009138479.1 134 SQYRGVTFYRRTGRWESHIWD------CgKQVYLGGFDTAHAAARAYDRAAIKFRG 183
                     78*******************......55************************997 PP

2AP243.29.8e-14226276155
             AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                     s+y+GV+ +k  grW+A+   +     +k+++lg f+t+ eAa+a+++a+ k +g
  XP_009138479.1 226 SKYRGVTLHK-CGRWEARMGQF--L-GKKYVYLGLFDTEVEAARAYDKAAIKCNG 276
                     89********.7******5553..2.26**********99**********99776 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541717.19E-16134192IPR016177DNA-binding domain
PfamPF008474.8E-9134183IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.104.4E-17135191IPR001471AP2/ERF domain
PROSITE profilePS5103217.596135191IPR001471AP2/ERF domain
SMARTSM003809.6E-32135197IPR001471AP2/ERF domain
CDDcd000181.67E-11135192No hitNo description
PfamPF008472.6E-9226276IPR001471AP2/ERF domain
CDDcd000187.43E-26226286No hitNo description
SuperFamilySSF541712.62E-17226286IPR016177DNA-binding domain
PROSITE profilePS5103215.672227284IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.1E-16227285IPR001471AP2/ERF domain
SMARTSM003806.3E-32227290IPR001471AP2/ERF domain
PRINTSPR003673.3E-6228239IPR001471AP2/ERF domain
PRINTSPR003673.3E-6266286IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010073Biological Processmeristem maintenance
GO:0010093Biological Processspecification of floral organ identity
GO:0048316Biological Processseed development
GO:0048481Biological Processplant ovule development
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 432 aa     Download sequence    Send to blast
MWDLNDSPHQ TVRQEESEEF CYSSPGKRVG SFSTSSSSAV VIEDGSDDDE PNRVRPNNPL  60
ITHQFFPEME SSVGDNGGGG TGPGFPRSHW FGVQFSQSDL ATGSSVGKPA TVGAVVEPTQ  120
PLKKSRRGPR SRSSQYRGVT FYRRTGRWES HIWDCGKQVY LGGFDTAHAA ARAYDRAAIK  180
FRGVEADINF NIEDYDNDMK QMTNLTKEEF VHVLRRQSTG FPRGSSKYRG VTLHKCGRWE  240
ARMGQFLGKK YVYLGLFDTE VEAARAYDKA AIKCNGKDAV TNFDSSIYDE ELNAESSGNP  300
IQQDHNLDLS LGNSVNSKHK GQDMRLKMNQ QDSLHSNEIL GLGQTGMVNY IPNSVHQFPG  360
SSNIHRGGGF SLFPVTENHQ FEGRTTANQV LANAAASSGF SPHNHNQIFN STPTSHQNWL  420
QTNGFQPPLM RP
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Bra.13790.0bud| silique
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: It is detectable at low levels throughout the shoot apex and at enhanced levels in the inflorescence meristem, young floral buds and throughout the early stages of flower development and organogenesis. During floral organ differentiation it becomes spatially restricted to specific organ, tissue and cell types within the flower.
UniprotTISSUE SPECIFICITY: Sepals, petals, stamens, carpels, developing ovules, inflorescence stem, leaf and stem.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcriptional activator that promotes early floral meristem identity (PubMed:7919989). Is required subsequently for the transition of an inflorescence meristem into a floral meristem (PubMed:1675158). Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes (PubMed:1675158, PubMed:23034631). Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and SEUSS (PubMed:1675158). Directly represses AGAMOUS by recruiting the transcriptional corepressor TOPLESS and the histone deacetylase HDA19 (PubMed:23034631). It is also required during seed development (PubMed:1675158). {ECO:0000269|PubMed:1675158, ECO:0000269|PubMed:23034631, ECO:0000269|PubMed:7919989}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_009138479.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Negatively regulated by the C class floral homeotic protein AGAMOUS in stamens and carpels. MicroRNA 172 (miRNA172) negatively regulates APETALA2 at the translational level and may modulate its expression pattern. Seems not to be influenced by jasmonate and Alternaria brassicicola. {ECO:0000269|PubMed:12805630, ECO:0000269|PubMed:12893888, ECO:0000269|PubMed:14555699}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ4826450.0KJ482645.1 Brassica juncea cultivar Pusa Bold APETALA2-1 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009138479.10.0PREDICTED: floral homeotic protein APETALA 2 isoform X1
RefseqXP_013742525.10.0floral homeotic protein APETALA 2 isoform X1
SwissprotP479270.0AP2_ARATH; Floral homeotic protein APETALA 2
TrEMBLW5QMD80.0W5QMD8_BRAJU; AP2 variant 3
STRINGBra017809.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM22972875
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G36920.20.0AP2 family protein
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Thamilarasan SK,Park JI,Jung HJ,Nou IS
    Genome-wide analysis of the distribution of AP2/ERF transcription factors reveals duplication and CBFs genes elucidate their potential function in Brassica oleracea.
    BMC Genomics, 2014. 15: p. 422
    [PMID:24888752]
  3. Zhang GB,Yi HY,Gong JM
    The Arabidopsis ethylene/jasmonic acid-NRT signaling module coordinates nitrate reallocation and the trade-off between growth and environmental adaptation.
    Plant Cell, 2014. 26(10): p. 3984-98
    [PMID:25326291]
  4. Ranocha P,Francoz E,Burlat V,Dunand C
    Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion.
    Plant Signal Behav, 2014. 9(11): p. e977734
    [PMID:25531128]
  5. Djemal R,Khoudi H
    Isolation and molecular characterization of a novel WIN1/SHN1 ethylene-responsive transcription factor TdSHN1 from durum wheat (Triticum turgidum. L. subsp. durum).
    Protoplasma, 2015. 252(6): p. 1461-73
    [PMID:25687296]
  6. Kazan K
    Diverse roles of jasmonates and ethylene in abiotic stress tolerance.
    Trends Plant Sci., 2015. 20(4): p. 219-29
    [PMID:25731753]
  7. Prunet N, et al.
    SQUINT promotes stem cell homeostasis and floral meristem termination in Arabidopsis through APETALA2 and CLAVATA signalling.
    J. Exp. Bot., 2015. 66(21): p. 6905-16
    [PMID:26269626]
  8. Xie W, et al.
    Exploring potential new floral organ morphogenesis genes of Arabidopsis thaliana using systems biology approach.
    Front Plant Sci, 2015. 6: p. 829
    [PMID:26528302]
  9. Zumajo-Cardona C,Pabón-Mora N
    Evolution of the APETALA2 Gene Lineage in Seed Plants.
    Mol. Biol. Evol., 2016. 33(7): p. 1818-32
    [PMID:27030733]
  10. Zhao Y, et al.
    An alternative strategy for targeted gene replacement in plants using a dual-sgRNA/Cas9 design.
    Sci Rep, 2016. 6: p. 23890
    [PMID:27033976]
  11. Gao R,Liu P,Irwanto N,Loh R,Wong SM
    Upregulation of LINC-AP2 is negatively correlated with AP2 gene expression with Turnip crinkle virus infection in Arabidopsis thaliana.
    Plant Cell Rep., 2016. 35(11): p. 2257-2267
    [PMID:27473526]
  12. Huang Z, et al.
    APETALA2 antagonizes the transcriptional activity of AGAMOUS in regulating floral stem cells in Arabidopsis thaliana.
    New Phytol., 2017. 215(3): p. 1197-1209
    [PMID:27604611]
  13. Dory M, et al.
    Kinase-Associated Phosphoisoform Assay: a novel candidate-based method to detect specific kinase-substrate phosphorylation interactions in vivo.
    BMC Plant Biol., 2016. 16(1): p. 204
    [PMID:27655033]
  14. Wang P, et al.
    Expansion and Functional Divergence of AP2 Group Genes in Spermatophytes Determined by Molecular Evolution and Arabidopsis Mutant Analysis.
    Front Plant Sci, 2016. 7: p. 1383
    [PMID:27703459]
  15. Sharma P, et al.
    Promoter Trapping and Deletion Analysis Show Arabidopsis thaliana APETALA2 Gene Promoter Is Bidirectional and Functions as a Pollen- and Ovule-Specific Promoter in the Reverse Orientation.
    Appl. Biochem. Biotechnol., 2017. 182(4): p. 1591-1604
    [PMID:28130768]
  16. Kihira M, et al.
    Arabidopsis thaliana FLO2 is Involved in Efficiency of Photoassimilate Translocation, Which is Associated with Leaf Growth and Aging, Yield of Seeds and Seed Quality.
    Plant Cell Physiol., 2017. 58(3): p. 440-450
    [PMID:28158741]
  17. Balanzà V, et al.
    Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway.
    Nat Commun, 2018. 9(1): p. 565
    [PMID:29422669]
  18. Dotto M,Gómez MS,Soto MS,Casati P
    UV-B radiation delays flowering time through changes in the PRC2 complex activity and miR156 levels in Arabidopsis thaliana.
    Plant Cell Environ., 2018. 41(6): p. 1394-1406
    [PMID:29447428]
  19. Song C,Lee J,Kim T,Hong JC,Lim CO
    VOZ1, a transcriptional repressor of DREB2C, mediates heat stress responses in Arabidopsis.
    Planta, 2018. 247(6): p. 1439-1448
    [PMID:29536220]