PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009109389.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family AP2
Protein Properties Length: 562aa    MW: 62511.7 Da    PI: 7.3735
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009109389.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP249.69.5e-16288347155
             AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 
                     s+y+GV++++++gr++A+++d   +  g  ++ ++++lg ++ +e+Aa+a++ a++k++g
  XP_009109389.1 288 SQYRGVTRHRWTGRYEAHLWDnSFKkEGhsRKgRQVYLGGYDMEEKAARAYDLAALKYWG 347
                     78*******************644456687446*************************98 PP

2AP246.78e-15390441155
             AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                     s y+GV+++++ grW A+I  +     +k  +lg+fgt eeA +a++ a+ k++g
  XP_009109389.1 390 SIYRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFGTQEEAGEAYDVAAIKFRG 441
                     57****************988532...5************************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008476.6E-13288347IPR001471AP2/ERF domain
CDDcd000182.42E-21288354No hitNo description
SuperFamilySSF541711.31E-16288357IPR016177DNA-binding domain
PROSITE profilePS5103218.755289355IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.102.2E-15289355IPR001471AP2/ERF domain
SMARTSM003802.3E-26289361IPR001471AP2/ERF domain
PRINTSPR003671.2E-6290301IPR001471AP2/ERF domain
PfamPF008472.7E-10390441IPR001471AP2/ERF domain
SuperFamilySSF541716.54E-17390450IPR016177DNA-binding domain
CDDcd000181.32E-24390451No hitNo description
Gene3DG3DSA:3.30.730.103.9E-17391449IPR001471AP2/ERF domain
SMARTSM003807.3E-32391455IPR001471AP2/ERF domain
PROSITE profilePS5103218.307391449IPR001471AP2/ERF domain
PRINTSPR003671.2E-6431451IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007276Biological Processgamete generation
GO:0010492Biological Processmaintenance of shoot apical meristem identity
GO:0042127Biological Processregulation of cell proliferation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 562 aa     Download sequence    Send to blast
MKSFCDNDDN DHSNTTNLLG FSLSSNMLKI GGSEGEALYS SSSSSVATCS VPPQLVVGDN  60
SSSYGVCYGS NSAAGDIYSQ MSVMPLRSDG SLCLMEALNR SSYSNHHHHT QVSSPKIEDF  120
FGTHHSNTNH KETMDLSLDS LFYNTTHEAD NNTNFQEFFS FPQTRNHHEE ESRNYESVPG  180
LTHGRGPFNV GVYGEFQQSL SLSMSPGSQS SCITGTHHHQ NQNHQGHNQT QNHHQISEAL  240
VETNVGFETT TMAAARKKKR GQEEVVVVGQ KQQTVHRKSI DTFGQRTSQY RGVTRHRWTG  300
RYEAHLWDNS FKKEGHSRKG RQVYLGGYDM EEKAARAYDL AALKYWGPST HTNFSVEIYQ  360
KEIEDMKNMT RQEHVAHLRR RSSGFSRGAS IYRGVTRHHQ HGRWQARIGR VAGNKDLYLG  420
TFGTQEEAGE AYDVAAIKFR GTNAVTNFDI TRYDVDRIMS SNTLLSGELA RRNSNSIVVR  480
NNNDEETALN AVLDGGSNKK VSGPERVLGF PGNFSLPQDG PKMFGANVVG NMSSWTTNPN  540
AELKAVSITL PQMPVFAAWA DS
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in floral primordia, in STM-negative region, then in sepal primordia. As sepal develops, progressively confined to a basal core before disappearing. Present in stamen primordia, then confined to a central region as they become stalked and develop locules. Later reduced to procambial cells as stamen mature. From petal primordia, expressed on the lateral edges of developing petals and finally confined to petal epidermis before disappearing. Present in carpel primordia, then in inner side of carpels especially in the placenta. Strong levels in ovules primordia and young ovules, then localized in integuments initiation zone before being confined to inner integument cells that will differentiate into the endothelium. Expressed in the distal half of the funiculus throughout ovule development and later extends into the chalaza. After fertilization, expression shift to the embryo. First on the apical part at the globular stage, then in cotyledons primordia, and later in cotyledons during the torpedo stage. As cotyledons grow out, expression becomes limited to a plane separating adaxial and abaxial parts. Excluded from the embryonic central region (ECR). In seedlings, found in leaf primordia then in central and lateral actively developing regions of extending leaves. {ECO:0000269|PubMed:10656774, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9671577}.
UniprotTISSUE SPECIFICITY: Mostly expressed in developing flowers. Also present in mature flowers, siliques and seedlings, but not in mature roots, leaves and stems. Expressed in ovules and in vegetative and floral primordia. {ECO:0000269|PubMed:15988559, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00088SELEXTransfer from AT4G37750Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_009109389.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankDQ2119700.0DQ211970.1 Brassica napus aintegumenta 2 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009109389.10.0PREDICTED: AP2-like ethylene-responsive transcription factor ANT isoform X1
SwissprotQ389140.0ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLQ3HLW80.0Q3HLW8_BRANA; Aintegumenta 2
STRINGBra010610.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM31372863
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G37750.10.0AP2 family protein
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  3. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  4. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  5. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  6. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  7. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  8. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  9. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  10. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  11. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]