PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GSBRNA2T00094943001
Common NameGSBRNA2T00094943001
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 368aa    MW: 41545.8 Da    PI: 5.7057
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GSBRNA2T00094943001genomeGenoscopeView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.71.5e-26135200171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                          r+++sL+llt+kf++l++++e+g ++ln +a+ L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  GSBRNA2T00094943001 135 RYDSSLGLLTKKFVNLIREAEDGSLDLNYCADVL---EV--QKRRIYDITNVLEGVGLIEKTTKNHIRWKG 200
                          6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.3E-28131202IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.07E-17135198IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.3E-33135200IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.1E-24137200IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.19E-41211318No hitNo description
SuperFamilySSF1440747.85E-29212317No hitNo description
PfamPF164211.6E-27216315IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 368 aa     Download sequence    Send to blast
MAATSKSGED PSLSYKHRSP FRFELIHSPS PTDPLHSSST NRPLSVPQPQ IQAHWDESFS  60
PIPITQKLQK SRKNHSISSS SMPGETIDIA KVIVKQESPQ DNTKRGTKSK VTKLSKSVKR  120
EGLQLSGPNG SNNCRYDSSL GLLTKKFVNL IREAEDGSLD LNYCADVLEV QKRRIYDITN  180
VLEGVGLIEK TTKNHIRWKG ADNLGQLELG NQISRLKLEV ESMQSEENRL DDLIRERQEA  240
LRSLEEDEHC KRYMFMTEED ITSLPCFQNQ TLLAIKAPTA SCIEVPDPDE VMSFPQRQYR  300
MVIRSRMGPI DVYLLSKHKG DSSMETDESA VDTSSLKIVT SDTDLKTDYW FESGEEVTLT  360
DLWNNFC*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-24135201774PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected at the G1/S transition, but increases during the progression into S phase and peaks after the passage into G2. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:12468727}.
UniprotTISSUE SPECIFICITY: Expressed in meristematic areas, vascular tissues, apical part of the roots, cotyledons, upper region of the hypocotyls, trichomes, young flower buds and pollen grains. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782}.
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGSBRNA2T00094943001
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankJN9429730.0JN942973.1 Brassica juncea E2F transcription factor (E2Fc) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009107402.10.0PREDICTED: transcription factor E2FC isoform X3
SwissprotQ9FV700.0E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A078FX940.0A0A078FX94_BRANA; BnaA08g03620D protein
TrEMBLA0A397Y7N50.0A0A397Y7N5_BRACM; Uncharacterized protein
TrEMBLM4DC830.0M4DC83_BRARP; Uncharacterized protein
STRINGBra014096.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.10.0E2F/DP family protein
Publications ? help Back to Top
  1. Chalhoub B, et al.
    Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome.
    Science, 2014. 345(6199): p. 950-3
    [PMID:25146293]
  2. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  3. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  4. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]