PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GSBRNA2T00092264001
Common NameGSBRNA2T00092264001
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 359aa    MW: 40504.5 Da    PI: 7.5612
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GSBRNA2T00092264001genomeGenoscopeView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP65.28.6e-212388171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rkeksL++l ++f++++++ + +   ++e+a +L    v  +rRRiYD++N+Le+++++++k kn ++w+g
  GSBRNA2T00092264001 23 RKEKSLGVLVSNFVRIYNRDDVDLFGIDEAAAKL---GV--ERRRIYDVVNILESIEVVSRKGKNLYSWNG 88
                         79*****************999************...**..****************************98 PP

2E2F_TDP82.92.6e-26148228171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          +ke+sL+ll+q+f+k++ +s+++ +tl+++ak+L+s+     ++++k+RR+YDi+NVL++++liek     ++k++++w g
  GSBRNA2T00092264001 148 KKESSLWLLSQNFVKMFLCSHDDLITLDSAAKALLSDsqdpmHMRTKVRRLYDIANVLSSMELIEKthipgTRKPAYKWLG 228
                          689****************************************************************************87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.2E-222089IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.72E-152286IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.6E-242388IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.7E-172488IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.3E-21146230IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.7E-30148228IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.7E-20149228IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.09E-12151229IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 359 aa     Download sequence    Send to blast
MEKMPWIVSS QDVDALALQS YSRKEKSLGV LVSNFVRIYN RDDVDLFGID EAAAKLGVER  60
RRIYDVVNIL ESIEVVSRKG KNLYSWNGFL HIPRSLHQLK EEGLREGFGT SSICSNSDKV  120
SLDDESEESL CLTPDDQDNS SLSKLEHKKE SSLWLLSQNF VKMFLCSHDD LITLDSAAKA  180
LLSDSQDPMH MRTKVRRLYD IANVLSSMEL IEKTHIPGTR KPAYKWLGSK SLTEKGSILF  240
NSPNESKKRV FGTEITNFST KRNKTDCSSN YVQNGYKKHD EEEKKPAAKS YVFGPFSPTA  300
ASKNNNNNNA GTSNSGRLQD LEALSSTYKP QYCNQDVTGL LGHYTEAWNK WFAELDRK*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-31222203228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in mid-S phase. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:15308755}.
UniprotTISSUE SPECIFICITY: High expression in young cotyledons and leaves, hypocotyls, shoot apical meristem, roots and mature pollen grains, moderate in developing trichomes, flowers and at early stages of developing anthers, and barely detectable in mature leaves. Not detected in primary root meristem, emerging lateral roots, pistils, developing embryos and siliques. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGSBRNA2T00092264001
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013587510.10.0PREDICTED: E2F transcription factor-like E2FF
SwissprotQ8RWL01e-180E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A078IDZ30.0A0A078IDZ3_BRANA; BnaC05g48730D protein
STRINGBo5g155250.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-164DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]
  2. Chalhoub B, et al.
    Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome.
    Science, 2014. 345(6199): p. 950-3
    [PMID:25146293]