PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GSBRNA2T00087787001
Common NameGSBRNA2T00087787001
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 376aa    MW: 42407.4 Da    PI: 7.342
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GSBRNA2T00087787001genomeGenoscopeView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP75.84.2e-242388171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rk+ksL+ll+++fl+l+++   +++ l+++a++L    v  +rRRiYDi+NVLe++++++k++kn+++wkg
  GSBRNA2T00087787001 23 RKQKSLGLLCTNFLALYNRHGIETIGLDDAASKL---GV--ERRRIYDIVNVLESVGVLTKRAKNQYTWKG 88
                         79*****************999************...**..****************************98 PP

2E2F_TDP79.92.2e-25159239171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          r+eksL+lltq+f+kl+ +se++i++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  GSBRNA2T00087787001 159 RREKSLGLLTQNFIKLFVCSEARIISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthsldSRKPAFKWLG 239
                          689**************************************999************************9999*******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.9E-271990IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.26E-162286IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.9E-292388IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.3E-212488IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.3E-23157240IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-32159239IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.0E-20161239IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.3E-14161240IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 376 aa     Download sequence    Send to blast
MSDLPPENPN LTLTSSLHHS YSRKQKSLGL LCTNFLALYN RHGIETIGLD DAASKLGVER  60
RRIYDIVNVL ESVGVLTKRA KNQYTWKGFS AIPAALKELQ EEGAKDTFHR FYTNENVKVS  120
DDEDDEEVSS SQPLSSCQTD TSKPGSLPQS SDPSKIDNRR EKSLGLLTQN FIKLFVCSEA  180
RIISLDEAAK LLLGDAHNTS IMRTKVRRLY DIANVLSSMN LIEKTHSLDS RKPAFKWLGY  240
NGEPTFTLSS DLMQAESKKR VFGTDLTNVS VKRSRTHENA TERRIKMKQH AIADSSYNQS  300
SDDAHESRGY EFGPFAPAAG GTYPAARLED NSKRAFDVEN LVSDYRPSYQ NQVLKDLFAH  360
YMDAWKSWYS ELTQNN
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-39222313228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapGSBRNA2T00087787001
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3531970.0AK353197.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-26-N13.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013737731.20.0E2F transcription factor-like E2FE
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A078JSQ70.0A0A078JSQ7_BRANA; BnaCnng63530D protein (Fragment)
STRINGBo8g076700.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.20.0DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Chalhoub B, et al.
    Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome.
    Science, 2014. 345(6199): p. 950-3
    [PMID:25146293]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]