PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GSBRNA2T00086200001
Common NameGSBRNA2T00086200001, GSBRNA2T00090960001, LOC106356636, LOC106379445, LOC106444805
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family LBD
Protein Properties Length: 203aa    MW: 22093.8 Da    PI: 7.5609
Description LBD family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GSBRNA2T00086200001genomeGenoscopeView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
               DUF260   1 aCaaCkvlrrkCakdCvlapyfpaeqpkkfanvhklFGasnvlkllkalpeeeredamsslvyeAearardPvyGavgvilklqqqleql 90 
                          +CaaCk+lrrkC+++Cv+apyfp +qp+kfanvhk+FGasnv+kll++l++++reda++sl+yeA++r+rdPvyG+vgvi+ lq+ql+ql
                          7***************************************************************************************** PP

               DUF260  91 kaelallkee 100
                          + +l+ +k+e
  GSBRNA2T00086200001  99 QIDLSCAKSE 108
                          ****999887 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5089127.2018109IPR004883Lateral organ boundaries, LOB
PfamPF031951.2E-449106IPR004883Lateral organ boundaries, LOB
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009799Biological Processspecification of symmetry
GO:0009944Biological Processpolarity specification of adaxial/abaxial axis
GO:0009954Biological Processproximal/distal pattern formation
GO:0048441Biological Processpetal development
GO:0005654Cellular Componentnucleoplasm
Sequence ? help Back to Top
Protein Sequence    Length: 203 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5ly0_A2e-5431125114LOB family transfactor Ramosa2.1
5ly0_B2e-5431125114LOB family transfactor Ramosa2.1
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in young shoots, roots, stems, leaves, flowers and adaxial domains of cotyledonary and leaves primordia. {ECO:0000269|PubMed:12040093, ECO:0000269|PubMed:12068116, ECO:0000269|PubMed:17559509}.
Functional Description ? help Back to Top
Source Description
UniProtNegative regulator of cell proliferation in the adaxial side of leaves. Regulates the formation of a symmetric lamina and the establishment of venation. Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV. Interacts directly with ASYMMETRIC LEAVES 1 (AS1) to repress the knox homeobox genes KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3, KAN2 and YAB5. May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis (PubMed:11311158, PubMed:12787254, PubMed:12874130, PubMed:14508003, PubMed:16006579, PubMed:16699177, PubMed:17395603, PubMed:17559509). Required for the binding of AS1 to the KNOX genes (PubMed:23271976). Involved in leaf polarity establishment by functioning cooperatively with RH10 or RID2 to repress abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial development in leaf primordia at shoot apical meristems at high temperatures (PubMed:27334696). {ECO:0000269|PubMed:11311158, ECO:0000269|PubMed:12787254, ECO:0000269|PubMed:12874130, ECO:0000269|PubMed:14508003, ECO:0000269|PubMed:16006579, ECO:0000269|PubMed:16699177, ECO:0000269|PubMed:17395603, ECO:0000269|PubMed:17559509, ECO:0000269|PubMed:23271976, ECO:0000269|PubMed:27334696}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00211DAPTransfer from AT1G65620Download
Motif logo
Cis-element ? help Back to Top
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Negatively regulated by SHOOT MERISTEMLESS (STM). {ECO:0000269|PubMed:11934861}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0808020.0AB080802.1 Arabidopsis thaliana AS2 mRNA for ASYMMETRIC LEAVES2, complete cds.
GenBankAB4738330.0AB473833.1 Arabidopsis thaliana AS2 mRNA for ASYMMETRIC LEAVES2, complete cds.
GenBankAF4478870.0AF447887.1 Arabidopsis thaliana LOB DOMAIN 6 (LBD6) mRNA, complete cds.
GenBankAY5194830.0AY519483.1 Arabidopsis thaliana ecotype Blanes AS2 (At1G65620) gene, complete cds.
GenBankBT0251630.0BT025163.1 Arabidopsis thaliana At1g65620 mRNA, complete cds.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
GenBankF5I140.0AC001229.1 Sequence of BAC F5I14 from Arabidopsis thaliana chromosome 1, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009127445.11e-150PREDICTED: LOB domain-containing protein 6
RefseqXP_009127446.11e-150PREDICTED: LOB domain-containing protein 6
RefseqXP_009127447.11e-150PREDICTED: LOB domain-containing protein 6
RefseqXP_013651820.11e-150LOB domain-containing protein 6
RefseqXP_013651821.11e-150LOB domain-containing protein 6
RefseqXP_013651823.11e-150LOB domain-containing protein 6
RefseqXP_013651824.11e-150LOB domain-containing protein 6
RefseqXP_013674846.11e-150LOB domain-containing protein 6
RefseqXP_013674847.11e-150LOB domain-containing protein 6
RefseqXP_013674848.11e-150LOB domain-containing protein 6
RefseqXP_013674850.11e-150LOB domain-containing protein 6
RefseqXP_013741687.11e-150LOB domain-containing protein 6
RefseqXP_013741688.11e-150LOB domain-containing protein 6
RefseqXP_013741689.11e-150LOB domain-containing protein 6
RefseqXP_013741690.11e-150LOB domain-containing protein 6
RefseqXP_013741691.11e-150LOB domain-containing protein 6
RefseqXP_022544627.11e-150LOB domain-containing protein 6
RefseqXP_022557333.11e-150LOB domain-containing protein 6
RefseqXP_022557336.11e-150LOB domain-containing protein 6
RefseqXP_022566475.11e-150LOB domain-containing protein 6
SwissprotO044791e-126AS2_ARATH; Protein ASYMMETRIC LEAVES 2
TrEMBLA0A078IA771e-149A0A078IA77_BRANA; BnaA02g12180D protein
TrEMBLA0A0D3AN841e-149A0A0D3AN84_BRAOL; Uncharacterized protein
TrEMBLA0A291LR371e-149A0A291LR37_BRARR; Transcription factor LBD6
TrEMBLA0A398A9S11e-149A0A398A9S1_BRACM; Uncharacterized protein
TrEMBLA0A3P6DNB21e-149A0A3P6DNB2_BRAOL; Uncharacterized protein
TrEMBLM4FF611e-149M4FF61_BRARP; Uncharacterized protein
STRINGBra039733.1-P1e-150(Brassica rapa)
STRINGBo2g051420.11e-150(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G65620.41e-129LBD family protein
Publications ? help Back to Top
  1. Chalhoub B, et al.
    Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome.
    Science, 2014. 345(6199): p. 950-3
  2. Machida C,Nakagawa A,Kojima S,Takahashi H,Machida Y
    The complex of ASYMMETRIC LEAVES (AS) proteins plays a central role in antagonistic interactions of genes for leaf polarity specification in Arabidopsis.
    Wiley Interdiscip Rev Dev Biol, 2015 Nov-Dec. 4(6): p. 655-71
  3. Mateo-BonmatĂ­ E, et al.
    Plastid control of abaxial-adaxial patterning.
    Sci Rep, 2015. 5: p. 15975
  4. Li Z, et al.
    Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis.
    J Integr Plant Biol, 2016. 58(12): p. 959-970
  5. Matsumura Y, et al.
    A genetic link between epigenetic repressor AS1-AS2 and a putative small subunit processome in leaf polarity establishment of Arabidopsis.
    Biol Open, 2016. 5(7): p. 942-54
  6. Wang Z,Wang Y,Kohalmi SE,Amyot L,Hannoufa A
    SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 2 controls floral organ development and plant fertility by activating ASYMMETRIC LEAVES 2 in Arabidopsis thaliana.
    Plant Mol. Biol., 2016. 92(6): p. 661-674
  7. Vial-Pradel S, et al.
    Arabidopsis Zinc-Finger-Like Protein ASYMMETRIC LEAVES2 (AS2) and Two Nucleolar Proteins Maintain Gene Body DNA Methylation in the Leaf Polarity Gene ETTIN (ARF3).
    Plant Cell Physiol., 2018. 59(7): p. 1385-1397
  8. Silverblatt-Buser EW,Frick MA,Rabeler C,Kaplinsky NJ
    Genetic Interactions Between BOB1 and Multiple 26S Proteasome Subunits Suggest a Role for Proteostasis in Regulating Arabidopsis Development.
    G3 (Bethesda), 2018. 8(4): p. 1379-1390