PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GSBRNA2T00077252001
Common NameGSBRNA2T00077252001
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 490aa    MW: 53132 Da    PI: 4.611
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GSBRNA2T00077252001genomeGenoscopeView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.43.7e-26168233171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                          r+++sL+llt+kf++l++++++g+++ln++a++L   +v  ++RRiYDi+NVLe+++liek  kn+i wkg
  GSBRNA2T00077252001 168 RYDSSLGLLTRKFVNLIKQAKDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIDLIEKPFKNQILWKG 233
                          6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.0E-28164235IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.7E-32168233IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.31E-16168231IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.0E-22170233IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146608.55E-47246350No hitNo description
SuperFamilySSF1440741.99E-31246350No hitNo description
PfamPF164211.1E-31249348IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 490 aa     Download sequence    Send to blast
MSGGARSSPG PSQPPPPHHP PSSPSPSSSL PVVPPIRRNL AFASTKPPFS PSDYHRFAPS  60
HLTDNDKSLV NVCELVDRED DDVVVHRSPS RKRKTTTDVV AATSDSNGLT SSGFSTLSNS  120
PCKTPVSAKG GRVNTKSKAK GSQSIPQTPI SNAVVGSPAT LTPSGSCRYD SSLGLLTRKF  180
VNLIKQAKDG MLDLNKAAET LEVQKRRIYD ITNVLEGIDL IEKPFKNQIL WKGLDTSGPG  240
DVDADVSVLQ AEIENFSLEE QALDNEIRET EERLRELSEN EKNQKWLFVT EEDIKSLPGF  300
QNQTLIAVKA PHGTTLEVPD PDEAVDIPQR RYRIILRSTM GPIDVYLVSE FEKKFEDTNG  360
TATPPPPACL PIASCSGSSE NHEIEALTVD NKGTANEHQA SQDHAHAQPG DTSDLNHLQE  420
QVGGMLKITP SDVENDDTDY WLLSNADISM TDIWKTDSGI DWDYEIADVS TPPPVMGEIA  480
PTGIDSTPR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-23163234274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
18994SRKRKT
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGSBRNA2T00077252001
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankJN9429840.0JN942984.1 Brassica juncea E2F transcription factor (E2Fa) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009141554.10.0PREDICTED: transcription factor E2FA
RefseqXP_022574291.10.0transcription factor E2FA-like isoform X1
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A078HYU50.0A0A078HYU5_BRANA; BnaAnng07700D protein
TrEMBLA0A3P6CQQ40.0A0A3P6CQQ4_BRACM; Uncharacterized protein
STRINGBra017268.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]
  2. Chalhoub B, et al.
    Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome.
    Science, 2014. 345(6199): p. 950-3
    [PMID:25146293]