PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GSBRNA2T00063031001
Common NameGSBRNA2T00063031001, GSBRNA2T00081161001
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 385aa    MW: 43429.6 Da    PI: 8.8385
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GSBRNA2T00063031001genomeGenoscopeView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP75.84.4e-242691171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rk+ksL+ll+++fl+l+++   +++ l+++a++L    v  +rRRiYDi+NVLe++++++k++kn+++wkg
  GSBRNA2T00063031001 26 RKQKSLGLLCTNFLALYNRHGIETIGLDDAASKL---GV--ERRRIYDIVNVLESVGVLTKRAKNQYTWKG 91
                         79*****************999************...**..****************************98 PP

2E2F_TDP79.92.3e-25158238171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          r+eksL+lltq+f+kl+ +se++i++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  GSBRNA2T00063031001 158 RREKSLGLLTQNFIKLFVCSEARIISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtldSRKPAFKWLG 238
                          689**************************************999************************9999*******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.2E-272293IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.29E-162589IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.9E-292691IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.4E-212791IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.2E-23155239IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-32158238IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.99E-14160239IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.2E-20160238IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 385 aa     Download sequence    Send to blast
MSDLPPENPN LPLTSSSSSL HHSYSRKQKS LGLLCTNFLA LYNRHGIETI GLDDAASKLG  60
VERRRIYDIV NVLESVGVLT KRAKNQYTWK GFSAIPAALK ELQEEGAKDT FHRFYTNENV  120
KVSDDEDDEE ESSSQPLSSS QTDTSKPGSL DSSKIDNRRE KSLGLLTQNF IKLFVCSEAR  180
IISLDEAAKL LLGDAHNTSI MRTKVRRLYD IANVLSSMNL IEKTHTLDSR KPAFKWLGYN  240
GEPTFTLSSD LMQAESKKRV FGTDLTNVSV KRSRTHENAT ERRIKMKQHA IADSSYNQSS  300
DDAHESRRYK FGLFAPAAGG TYPAARLEDN SKRAFDVENL VSDYRPSYQN QVLKDLFAHY  360
MDAWKSWYSE VTQKNPLPDT SKRH*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-40252303228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGSBRNA2T00063031001
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3531970.0AK353197.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-26-N13.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018515445.10.0PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A078HES40.0A0A078HES4_BRANA; BnaA06g16850D protein
STRINGBra018080.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.20.0DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Chalhoub B, et al.
    Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome.
    Science, 2014. 345(6199): p. 950-3
    [PMID:25146293]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]