PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G67580.2
Common NameATTBP3, ATTRB2, K9I9.15, TBP3, TRB2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family MYB_related
Protein Properties Length: 299aa    MW: 33013.7 Da    PI: 10.6057
Description MYB_related family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G67580.2genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding40.18.7e-13555146
                     TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHT.....TTS-HHHHHHHHHH CS
  Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmg.....kgRtlkqcksrwqk 46
                     +++WT+eE+  l+ +v ++G+g W+tI +        k R+  ++k++w++
      AT5G67580.2  5 KQKWTPEEEAALKAGVLKHGTGKWRTILSDTEfslilKSRSNVDLKDKWRN 55
                     79***********************************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5129414.771161IPR017930Myb domain
SuperFamilySSF466891.64E-15261IPR009057Homeodomain-like
SMARTSM007174.6E-7459IPR001005SANT/Myb domain
PfamPF002492.4E-9555IPR001005SANT/Myb domain
Gene3DG3DSA:1.10.10.606.7E-14556IPR009057Homeodomain-like
CDDcd116601.11E-16656No hitNo description
SuperFamilySSF467851.58E-15118201IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.0E-11119186IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM005268.6E-12119184IPR005818Linker histone H1/H5, domain H15
PROSITE profilePS5150418.977121189IPR005818Linker histone H1/H5, domain H15
PfamPF005385.7E-9124182IPR005818Linker histone H1/H5, domain H15
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006334Biological Processnucleosome assembly
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009651Biological Processresponse to salt stress
GO:0009723Biological Processresponse to ethylene
GO:0009733Biological Processresponse to auxin
GO:0009737Biological Processresponse to abscisic acid
GO:0009739Biological Processresponse to gibberellin
GO:0009751Biological Processresponse to salicylic acid
GO:0009753Biological Processresponse to jasmonic acid
GO:0031627Biological Processtelomeric loop formation
GO:0046686Biological Processresponse to cadmium ion
GO:0000784Cellular Componentnuclear chromosome, telomeric region
GO:0000785Cellular Componentchromatin
GO:0000786Cellular Componentnucleosome
GO:0005730Cellular Componentnucleolus
GO:0003691Molecular Functiondouble-stranded telomeric DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0042803Molecular Functionprotein homodimerization activity
GO:0043047Molecular Functionsingle-stranded telomeric DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025195anatomypollen tube cell
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007131developmental stageseedling development stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 299 aa     Download sequence    Send to blast
MGAPKQKWTP EEEAALKAGV LKHGTGKWRT ILSDTEFSLI LKSRSNVDLK DKWRNISVTA  60
LWGSRKKAKL ALKRTPPGTK QDDNNTALTI VALTNDDERA KPTSPGGSGG GSPRTCASKR  120
SITSLDKIIF EAITNLRELR GSDRTSIFLY IEENFKTPPN MKRHVAVRLK HLSSNGTLVK  180
IKHKYRFSSN FIPAGARQKA PQLFLEGNNK KDPTKPEENG ANSLTKFRVD GELYMIKGMT  240
AQEAAEAAAR AVAEAEFAIT EAEQAAKEAE RAEAEAEAAQ IFAKAAMKAL KFRIRNHPW
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.76360.0bud| root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453620970.0
Genevisible247012_at0.0
Expression AtlasAT5G67580-
AtGenExpressAT5G67580-
ATTED-IIAT5G67580-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15060584}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a telomeric DNA binding protein. In vitro, the protein preferentially binds double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
UniProtBinds preferentially double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
Function -- GeneRIF ? help Back to Top
  1. structure and function of AtTRB2 protein
    [PMID: 22859734]
  2. Trp28, Arg29, and Val47 residues located in Helix 2 and Helix 3 of TRB2 are crucial for DNA binding, and are well conserved among other plant telomere binding proteins.
    [PMID: 25172657]
  3. TRB2 interacts with HD2-type histone deacetylase HDT4.TRB2 has a role in the regulation of telomeric chromatin.
    [PMID: 26857545]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00597DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G67580.2
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDabscisic acid, auxin, ethylene, gibberellin, jasmonic acid, salicylic acid
Interaction -- BIND ? help Back to Top
Source Intact With Description
BINDAT1G49950TRB1 interacts with TRB2.
BINDAT5G67580TRB2 interacts with another molecule of TRB2.
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G67580, AT1G49950
IntActSearch Q9FJW5
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G67580
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0398830.0AY039883.1 Arabidopsis thaliana AT5g67580/K9I9_15 mRNA, complete cds.
GenBankAY0776680.0AY077668.1 Arabidopsis thaliana AT5g67580/K9I9_15 mRNA, complete cds.
GenBankAY5195450.0AY519545.1 Arabidopsis thaliana MYB transcription factor (At5g67580) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_201559.10.0Homeodomain-like/winged-helix DNA-binding family protein
RefseqNP_851286.10.0Homeodomain-like/winged-helix DNA-binding family protein
SwissprotQ9FJW50.0TRB2_ARATH; Telomere repeat-binding factor 2
TrEMBLA0A178UR210.0A0A178UR21_ARATH; TRB2
STRINGAT5G67580.10.0(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Marian CO, et al.
    The maize Single myb histone 1 gene, Smh1, belongs to a novel gene family and encodes a protein that binds telomere DNA repeats in vitro.
    Plant Physiol., 2003. 133(3): p. 1336-50
    [PMID:14576282]
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  4. Schrumpfová P, et al.
    Characterization of two Arabidopsis thaliana myb-like proteins showing affinity to telomeric DNA sequence.
    Genome, 2004. 47(2): p. 316-24
    [PMID:15060584]
  5. Wierzbicki AT,Jerzmanowski A
    Suppression of histone H1 genes in Arabidopsis results in heritable developmental defects and stochastic changes in DNA methylation.
    Genetics, 2005. 169(2): p. 997-1008
    [PMID:15489532]
  6. Sottosanto JB,Gelli A,Blumwald E
    DNA array analyses of Arabidopsis thaliana lacking a vacuolar Na+/H+ antiporter: impact of AtNHX1 on gene expression.
    Plant J., 2004. 40(5): p. 752-71
    [PMID:15546358]
  7. Kuchar M,Fajkus J
    Interactions of putative telomere-binding proteins in Arabidopsis thaliana: identification of functional TRF2 homolog in plants.
    FEBS Lett., 2004. 578(3): p. 311-5
    [PMID:15589838]
  8. Yanhui C, et al.
    The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family.
    Plant Mol. Biol., 2006. 60(1): p. 107-24
    [PMID:16463103]
  9. Sottosanto JB,Saranga Y,Blumwald E
    Impact of AtNHX1, a vacuolar Na+/H+ antiporter, upon gene expression during short- and long-term salt stress in Arabidopsis thaliana.
    BMC Plant Biol., 2007. 7: p. 18
    [PMID:17411438]
  10. Schrumpfov
    Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana.
    FEBS Lett., 2008. 582(10): p. 1400-6
    [PMID:18387366]
  11. Chi W, et al.
    The pentratricopeptide repeat protein DELAYED GREENING1 is involved in the regulation of early chloroplast development and chloroplast gene expression in Arabidopsis.
    Plant Physiol., 2008. 147(2): p. 573-84
    [PMID:18400937]
  12. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  13. Wang Y, et al.
    Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
    Plant Physiol., 2008. 148(3): p. 1201-11
    [PMID:18775970]
  14. Dvorácková M, et al.
    AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin.
    Plant J., 2010. 61(4): p. 637-49
    [PMID:19947985]
  15. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  16. Lee WK,Yun JH,Lee W,Cho MH
    DNA-binding domain of AtTRB2 reveals unique features of a single Myb histone protein family that binds to both Arabidopsis- and human-type telomeric DNA sequences.
    Mol Plant, 2012. 5(6): p. 1406-8
    [PMID:22859734]
  17. Yun JH, et al.
    Solution structure of telomere binding domain of AtTRB2 derived from Arabidopsis thaliana.
    Biochem. Biophys. Res. Commun., 2014. 452(3): p. 436-42
    [PMID:25172657]
  18. Lee WK,Cho MH
    Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana.
    Nucleic Acids Res., 2016. 44(10): p. 4610-24
    [PMID:26857545]
  19. Kotliński M, et al.
    Phylogeny-Based Systematization of Arabidopsis Proteins with Histone H1 Globular Domain.
    Plant Physiol., 2017. 174(1): p. 27-34
    [PMID:28298478]