PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G67180.1
Common NameK21H1.14, TOE3
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family AP2
Protein Properties Length: 352aa    MW: 39594 Da    PI: 8.9876
Description target of early activation tagged (EAT) 3
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G67180.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP254.13.9e-1795144155
          AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkkleg 55 
                  s+y+GV++++++grW+++I+d      + k+++lg f+ta  Aa+a+++a+ k++g
  AT5G67180.1  95 SQYRGVTFYRRTGRWESHIWD------CgKQVYLGGFDTAHAAARAYDRAAIKFRG 144
                  78*******************......55************************997 PP

2AP2445.7e-14187237155
          AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkkleg 55 
                  s+y+GV+ +k  grW++++  +     + k+++lg f+t+ eAa+a+++a+ k +g
  AT5G67180.1 187 SKYRGVTLHK-CGRWESRLGQF----LNkKYVYLGLFDTEIEAARAYDKAAIKCNG 237
                  89********.7****995553....234**********99**********99776 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008473.5E-995144IPR001471AP2/ERF domain
SuperFamilySSF541713.99E-1695153IPR016177DNA-binding domain
PROSITE profilePS5103217.89996152IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.103.1E-1796152IPR001471AP2/ERF domain
CDDcd000182.75E-1196153No hitNo description
SMARTSM003802.8E-3196158IPR001471AP2/ERF domain
CDDcd000183.77E-24187245No hitNo description
PfamPF008474.0E-9187237IPR001471AP2/ERF domain
SuperFamilySSF541715.49E-17187246IPR016177DNA-binding domain
PROSITE profilePS5103215.488188245IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.107.6E-17188245IPR001471AP2/ERF domain
SMARTSM003805.7E-31188251IPR001471AP2/ERF domain
PRINTSPR003675.1E-6189200IPR001471AP2/ERF domain
PRINTSPR003675.1E-6227247IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007275Biological Processmulticellular organism development
GO:0009408Biological Processresponse to heat
GO:0009873Biological Processethylene-activated signaling pathway
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 352 aa     Download sequence    Send to blast
MWNLNDSPDH HEESDSRGNP VGHVSNGMSQ SATWLPFVLP VTRNFFPAQS MEPGVRWSGF  60
NSVGKSDPSG SGRPEEPEIS PPIKKSRRGP RSRSSQYRGV TFYRRTGRWE SHIWDCGKQV  120
YLGGFDTAHA AARAYDRAAI KFRGVDADIN FDIEDYLDDL KQMGNLTKEE FMHVLRRQST  180
GFPRGSSKYR GVTLHKCGRW ESRLGQFLNK KYVYLGLFDT EIEAARAYDK AAIKCNGKDA  240
VTNFDPKVYE EEEDLSSETT RNGHNLGLSL GESSSEEFRL KSDIASIRSR IRDEERLLGS  300
DLSLAMMTTT VRSEKQQSDG GGNRVVGMAA SSGFSPQPSP YRIPRTFHFS RP
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.288210.0inflorescence| leaf
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible247041_at0.0
Expression AtlasAT5G67180-
AtGenExpressAT5G67180-
ATTED-IIAT5G67180-
Functional Description ? help Back to Top
Source Description
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). May regulate negatively the transition to flowering time and confers flowering time delay. {ECO:0000250, ECO:0000269|PubMed:14555699, ECO:0000269|PubMed:15988559}.
Function -- GeneRIF ? help Back to Top
  1. Here, we demonstrate that miR172-mediated repression of the TARGET OF EAT 3 (TOE3) gene is critical for floral patterning in Arabidopsis.
    [PMID: 24388512]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G67180.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by miR172a-2/EAT. {ECO:0000269|PubMed:14555699}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G67180
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK1761450.0AK176145.1 Arabidopsis thaliana mRNA for floral homeotic protein apetala2-like, complete cds, clone: RAFL22-96-G17.
GenBankAY0882380.0AY088238.1 Arabidopsis thaliana clone 4623 mRNA, complete sequence.
GenBankBT0292060.0BT029206.1 Arabidopsis thaliana At5g67180 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_201519.10.0target of early activation tagged (EAT) 3
SwissprotQ9FH950.0TOE3_ARATH; AP2-like ethylene-responsive transcription factor TOE3
TrEMBLD7MKS60.0D7MKS6_ARALL; Uncharacterized protein
STRINGAT5G67180.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM22972875
Representative plantOGRP4971784
Publications ? help Back to Top
  1. Krizek BA,Prost V,Macias A
    AINTEGUMENTA promotes petal identity and acts as a negative regulator of AGAMOUS.
    Plant Cell, 2000. 12(8): p. 1357-66
    [PMID:10948255]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. Kasschau KD, et al.
    P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction.
    Dev. Cell, 2003. 4(2): p. 205-17
    [PMID:12586064]
  4. Keck E,McSteen P,Carpenter R,Coen E
    Separation of genetic functions controlling organ identity in flowers.
    EMBO J., 2003. 22(5): p. 1058-66
    [PMID:12606571]
  5. Aukerman MJ,Sakai H
    Regulation of flowering time and floral organ identity by a MicroRNA and its APETALA2-like target genes.
    Plant Cell, 2003. 15(11): p. 2730-41
    [PMID:14555699]
  6. Schmid M, et al.
    Dissection of floral induction pathways using global expression analysis.
    Development, 2003. 130(24): p. 6001-12
    [PMID:14573523]
  7. Ma S,Quist TM,Ulanov A,Joly R,Bohnert HJ
    Loss of TIP1;1 aquaporin in Arabidopsis leads to cell and plant death.
    Plant J., 2004. 40(6): p. 845-59
    [PMID:15584951]
  8. Axtell MJ,Bartel DP
    Antiquity of microRNAs and their targets in land plants.
    Plant Cell, 2005. 17(6): p. 1658-73
    [PMID:15849273]
  9. Nole-Wilson S,Tranby TL,Krizek BA
    AINTEGUMENTA-like (AIL) genes are expressed in young tissues and may specify meristematic or division-competent states.
    Plant Mol. Biol., 2005. 57(5): p. 613-28
    [PMID:15988559]
  10. Kim S,Soltis PS,Wall K,Soltis DE
    Phylogeny and domain evolution in the APETALA2-like gene family.
    Mol. Biol. Evol., 2006. 23(1): p. 107-20
    [PMID:16151182]
  11. Würschum T,Gross-Hardt R,Laux T
    APETALA2 regulates the stem cell niche in the Arabidopsis shoot meristem.
    Plant Cell, 2006. 18(2): p. 295-307
    [PMID:16387832]
  12. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
    [PMID:16407444]
  13. Cao D,Cheng H,Wu W,Soo HM,Peng J
    Gibberellin mobilizes distinct DELLA-dependent transcriptomes to regulate seed germination and floral development in Arabidopsis.
    Plant Physiol., 2006. 142(2): p. 509-25
    [PMID:16920880]
  14. Zhao J, et al.
    Analysis of gene expression profiles in response to Sclerotinia sclerotiorum in Brassica napus.
    Planta, 2007. 227(1): p. 13-24
    [PMID:17665211]
  15. Jung JH,Lee S,Yun J,Lee M,Park CM
    The miR172 target TOE3 represses AGAMOUS expression during Arabidopsis floral patterning.
    Plant Sci., 2014. 215-216: p. 29-38
    [PMID:24388512]
  16. Zumajo-Cardona C,Pabón-Mora N
    Evolution of the APETALA2 Gene Lineage in Seed Plants.
    Mol. Biol. Evol., 2016. 33(7): p. 1818-32
    [PMID:27030733]
  17. Ohme-Takagi M,Shinshi H
    Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element.
    Plant Cell, 1995. 7(2): p. 173-82
    [PMID:7756828]
  18. Jofuku KD,den Boer BG,Van Montagu M,Okamuro JK
    Control of Arabidopsis flower and seed development by the homeotic gene APETALA2.
    Plant Cell, 1994. 6(9): p. 1211-25
    [PMID:7919989]
  19. Okamuro JK,Caster B,Villarroel R,Van Montagu M,Jofuku KD
    The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 1997. 94(13): p. 7076-81
    [PMID:9192694]