PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G22570.1
Common NameATWRKY38, MQJ16.11, WRKY38
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family WRKY
Protein Properties Length: 289aa    MW: 33268.2 Da    PI: 5.4096
Description WRKY DNA-binding protein 38
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G22570.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRKY63.43.8e-20111170359
                  -SS-EEEEEEE--TT-SS-EEEEEE-ST...T---EEEEEE-SSSTTEEEEEEES--SS- CS
         WRKY   3 DgynWrKYGqKevkgsefprsYYrCtsa...gCpvkkkversaedpkvveitYegeHnhe 59 
                  Dgy WrKYGqK++k+s++ rsYYrC+++   +C+++k+ ++ +++p v  +tY g+H+++
  AT5G22570.1 111 DGYLWRKYGQKSIKKSNHQRSYYRCSYNkdhNCEARKHEQKIKDNPPVYRTTYFGHHTCK 170
                  9**************************99999**************************97 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5081119.749104172IPR003657WRKY domain
Gene3DG3DSA:2.20.25.802.0E-21104170IPR003657WRKY domain
SuperFamilySSF1182906.54E-21107171IPR003657WRKY domain
SMARTSM007742.1E-31109171IPR003657WRKY domain
PfamPF031068.0E-21111170IPR003657WRKY domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009863Biological Processsalicylic acid mediated signaling pathway
GO:0042742Biological Processdefense response to bacterium
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009047anatomystem
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 289 aa     Download sequence    Send to blast
MEMNSPHEKA VQAIRYGHSC AMRLKRRLNH PMADGGPLSS YDLAKSIVES FSNAISILSA  60
KPETEDDQFS DLSSRDSSPP PQGSPSKKRK IDSTNSSENW RDDSPDPIYY DGYLWRKYGQ  120
KSIKKSNHQR SYYRCSYNKD HNCEARKHEQ KIKDNPPVYR TTYFGHHTCK TEHNLDAIFI  180
AGQDPLDDFK STQMIRFGKD QDQEKESRSN GFSLSVKHEE DIIKEQAIDQ YREITSNDQD  240
CQDVIEEYLS SPSGSYPPSS SSGSESADFN SDLLFDNPDS WDRYDQFYF
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.273470.0root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306885390.0
Genevisible249890_at0.0
Expression AtlasAT5G22570-
AtGenExpressAT5G22570-
ATTED-IIAT5G22570-
Functional Description ? help Back to Top
Source Description
TAIRmember of WRKY Transcription Factor; Group III
UniProtTranscription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. WRKY38 and WRKY62 are transcriptional activators in plant cells that function additively as negative regulators of plant basal defense, but their activation activities are abolished by overexpressed HDA19.
    [PMID: 18776063]
  2. results suggest that PKS5 functions at the upstream of NPR1 and might mediate expression of WRKY38 and WRKY62 possibly by interacting with and phosphorylating NPR1.
    [PMID: 20621018]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00619PBM24477691Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G22570.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT2G14610(R)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDsalicylic acid
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G80840
IntActSearch Q8GWF1
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G22570
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK1188840.0AK118884.1 Arabidopsis thaliana At5g22570 mRNA for putative WRKY transcription factor 38 (WRKY38), complete cds, clone: RAFL21-21-O16.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_197649.20.0putative WRKY transcription factor 38
SwissprotQ8GWF10.0WRK38_ARATH; Probable WRKY transcription factor 38
TrEMBLQ700E50.0Q700E5_ARATH; Putative WRKY transcription factor 38
STRINGAT5G22570.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM136731727
Representative plantOGRP1417875
Publications ? help Back to Top
  1. Eulgem T,Rushton PJ,Robatzek S,Somssich IE
    The WRKY superfamily of plant transcription factors.
    Trends Plant Sci., 2000. 5(5): p. 199-206
    [PMID:10785665]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. Seki M, et al.
    Functional annotation of a full-length Arabidopsis cDNA collection.
    Science, 2002. 296(5565): p. 141-5
    [PMID:11910074]
  4. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  5. Hoth S, et al.
    Monitoring genome-wide changes in gene expression in response to endogenous cytokinin reveals targets in Arabidopsis thaliana.
    FEBS Lett., 2003. 554(3): p. 373-80
    [PMID:14623097]
  6. Gong W, et al.
    Genome-wide ORFeome cloning and analysis of Arabidopsis transcription factor genes.
    Plant Physiol., 2004. 135(2): p. 773-82
    [PMID:15208423]
  7. Scheible WR, et al.
    Genome-wide reprogramming of primary and secondary metabolism, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen.
    Plant Physiol., 2004. 136(1): p. 2483-99
    [PMID:15375205]
  8. Thilmony R,Underwood W,He SY
    Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7.
    Plant J., 2006. 46(1): p. 34-53
    [PMID:16553894]
  9. Che P,Lall S,Nettleton D,Howell SH
    Gene expression programs during shoot, root, and callus development in Arabidopsis tissue culture.
    Plant Physiol., 2006. 141(2): p. 620-37
    [PMID:16648215]
  10. Wang D,Amornsiripanitch N,Dong X
    A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants.
    PLoS Pathog., 2006. 2(11): p. e123
    [PMID:17096590]
  11. Sato M, et al.
    A high-performance, small-scale microarray for expression profiling of many samples in Arabidopsis-pathogen studies.
    Plant J., 2007. 49(3): p. 565-77
    [PMID:17181774]
  12. Krinke O, et al.
    Phosphatidylinositol 4-kinase activation is an early response to salicylic acid in Arabidopsis suspension cells.
    Plant Physiol., 2007. 144(3): p. 1347-59
    [PMID:17496105]
  13. Wang Z, et al.
    Identification and characterization of COI1-dependent transcription factor genes involved in JA-mediated response to wounding in Arabidopsis plants.
    Plant Cell Rep., 2008. 27(1): p. 125-35
    [PMID:17786451]
  14. Ciolkowski I,Wanke D,Birkenbihl RP,Somssich IE
    Studies on DNA-binding selectivity of WRKY transcription factors lend structural clues into WRKY-domain function.
    Plant Mol. Biol., 2008. 68(1-2): p. 81-92
    [PMID:18523729]
  15. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  16. Kim KC,Lai Z,Fan B,Chen Z
    Arabidopsis WRKY38 and WRKY62 transcription factors interact with histone deacetylase 19 in basal defense.
    Plant Cell, 2008. 20(9): p. 2357-71
    [PMID:18776063]
  17. Xie C,Zhou X,Deng X,Guo Y
    PKS5, a SNF1-related kinase, interacts with and phosphorylates NPR1, and modulates expression of WRKY38 and WRKY62.
    J Genet Genomics, 2010. 37(6): p. 359-69
    [PMID:20621018]
  18. Hanada K, et al.
    Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana.
    Mol. Biol. Evol., 2011. 28(1): p. 377-82
    [PMID:20736450]
  19. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  20. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]