PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G14960.1
Common NameDEL2, E2FD, E2L1, ELP3, F2G14.80
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family E2F/DP
Protein Properties Length: 359aa    MW: 40553 Da    PI: 8.6432
Description DP-E2F-like 2
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G14960.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP66.43.6e-211378171
      E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                 rk+ksL++l  +fl+l+++ + +   l+++a +L    v  +rRRiYD++N+Le+++l++++ kn+++wkg
  AT5G14960.1 13 RKDKSLGVLVANFLTLYNRPDVDLFGLDDAAAKL---GV--ERRRIYDVVNILESIGLVARSGKNQYSWKG 78
                 79****************9888************...**..****************************98 PP

2E2F_TDP76.91.9e-24138217171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                  rke++L+ll+q+f+kl+ +s+++ vt+++++k+L++e    ++++k+RR+YDi+NV+++++liek     ++k+++rw g
  AT5G14960.1 138 RKERTLWLLAQNFVKLFLCSDDDLVTFDSATKALLNEsqdmNMRKKVRRLYDIANVFSSMKLIEKthvpeTKKPAYRWLG 217
                  799******************************************************************99*******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.4E-221179IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.58E-151276IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.8E-251378IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.4E-181478IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.105.7E-20135219IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.0E-27138217IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.7E-16139217IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.21E-11141218IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007049Biological Processcell cycle
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009031anatomysepal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0009053anatomypeduncle
PO:0020094anatomyplant egg cell
PO:0025022anatomycollective leaf structure
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 359 aa     Download sequence    Send to blast
MDSLALAPQV YSRKDKSLGV LVANFLTLYN RPDVDLFGLD DAAAKLGVER RRIYDVVNIL  60
ESIGLVARSG KNQYSWKGFG AVPRALSELK EEGMKEKFAI VPFVAKSEMV VYEKEGEESF  120
MLSPDDQEFS PSPRPDNRKE RTLWLLAQNF VKLFLCSDDD LVTFDSATKA LLNESQDMNM  180
RKKVRRLYDI ANVFSSMKLI EKTHVPETKK PAYRWLGSKT IFENRFIDGS ASLCDRNVPK  240
KRAFGTELTN VNAKRNKSGC SKEDSKRNGN QNTSIVIKQE QCDDVKPDVK NFASGSSTPA  300
GTSESNDMGN NIRPRGRLGV IEALSTLYQP SYCNPELLGL FAHYNETFRS YQEEFGREK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-35122093228Transcription factor E2F8
Search in ModeBase
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306851360.0
Genevisible246568_at0.0
Expression AtlasAT5G14960-
AtGenExpressAT5G14960-
ATTED-IIAT5G14960-
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected at the G1/S transition, but increases during the progression into S phase and peaks after the passage into G2. {ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Preferentially expressed in proliferating tissues. Highly expressed in young stalk and young flowers. Lower expression in young leaves and mature flowers. Detected in cotyledonary vascular tissues, the shoot apical meristem, the base of trichomes, the fully developed stomata, the central root cylinder and in the columella of lateral roots but not in the primary root tips or in the leaf epidermal cells. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:19937368}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent regulation of gene expression. Binds specifically the E2 recognition site as a monomer without interacting with DP proteins. May be up-regulating E2FA and down-regulating repressors of cell cycle progression. Promotes cell proliferation and represses cell elongation. Regulated by proteolysis via a ubiquitin-proteasome pathway. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:19937368}.
Function -- GeneRIF ? help Back to Top
  1. E2FD/DEL2 accumulation is subject to negative post-translational regulation mediated by the plant hormone auxin.
    [PMID: 19937368]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00511DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G14960.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated posttranscroptionally by auxin. {ECO:0000269|PubMed:19937368}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT2G36010(A), AT3G48160(A), AT5G22220(A)
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Increased root length and smaller cotyledons. Reduced root meristematic zone but longer cells in the differentiation zone. {ECO:0000269|PubMed:19937368}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G14960
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0745310.0AB074531.1 Arabidopsis thaliana mRNA for E2F-like repressor E2L1, complete cds.
GenBankAJ4178350.0AJ417835.1 Arabidopsis thaliana mRNA for transcription factor E2Fd (e2Fd gene).
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_197000.10.0DP-E2F-like 2
SwissprotQ9LFQ90.0E2FD_ARATH; E2F transcription factor-like E2FD
TrEMBLA0A178UM450.0A0A178UM45_ARATH; E2L1
STRINGAT5G14960.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Representative plantOGRP24741634
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Mariconti L, et al.
    The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants.
    J. Biol. Chem., 2002. 277(12): p. 9911-9
    [PMID:11786543]
  3. Kosugi S,Ohashi Y
    E2Ls, E2F-like repressors of Arabidopsis that bind to E2F sites in a monomeric form.
    J. Biol. Chem., 2002. 277(19): p. 16553-8
    [PMID:11867638]
  4. Vandepoele K, et al.
    Genome-wide analysis of core cell cycle genes in Arabidopsis.
    Plant Cell, 2002. 14(4): p. 903-16
    [PMID:11971144]
  5. Zhang S, et al.
    Resources for targeted insertional and deletional mutagenesis in Arabidopsis.
    Plant Mol. Biol., 2003. 53(1-2): p. 133-50
    [PMID:14756312]
  6. Pina C,Pinto F,Feij
    Gene family analysis of the Arabidopsis pollen transcriptome reveals biological implications for cell growth, division control, and gene expression regulation.
    Plant Physiol., 2005. 138(2): p. 744-56
    [PMID:15908605]
  7. Day RC,Herridge RP,Ambrose BA,Macknight RC
    Transcriptome analysis of proliferating Arabidopsis endosperm reveals biological implications for the control of syncytial division, cytokinin signaling, and gene expression regulation.
    Plant Physiol., 2008. 148(4): p. 1964-84
    [PMID:18923020]
  8. Sozzani R, et al.
    The E2FD/DEL2 factor is a component of a regulatory network controlling cell proliferation and development in Arabidopsis.
    Plant Mol. Biol., 2010. 72(4-5): p. 381-95
    [PMID:19937368]
  9. Wuest SE, et al.
    Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes.
    Curr. Biol., 2010. 20(6): p. 506-12
    [PMID:20226671]
  10. Boruc J, et al.
    Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network.
    Plant Cell, 2010. 22(4): p. 1264-80
    [PMID:20407024]
  11. Van Leene J, et al.
    Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.
    Mol. Syst. Biol., 2010. 6: p. 397
    [PMID:20706207]
  12. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  13. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]