PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G14010.1
Common NameKNU, MAC12.2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 161aa    MW: 18049.1 Da    PI: 7.1926
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G14010.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H215.16.5e-053860123
                 EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2  1 ykCpdCgksFsrksnLkrHirtH 23
                 ++C++C++ F ++  L  H++ H
  AT5G14010.1 38 FPCQYCPRKFYTSQALGGHQNAH 60
                 89******************988 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576672.66E-63565No hitNo description
PROSITE profilePS5015711.0533865IPR007087Zinc finger, C2H2
PROSITE patternPS0002804060IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009909Biological Processregulation of flower development
GO:0010582Biological Processfloral meristem determinacy
GO:0030154Biological Processcell differentiation
GO:0005634Cellular Componentnucleus
GO:0003676Molecular Functionnucleic acid binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 161 aa     Download sequence    Send to blast
MAEPPPSYLH FVGPAKTRSS SKRHSFSSSA HPASHRLFPC QYCPRKFYTS QALGGHQNAH  60
KRERAAARRN LGVLANSPPI LDDNNTFLRP YPCFYQNPFQ GSTSGNEPLQ EQPTMMTMDG  120
YDPFHPYPYV YPFALSGNNN DGGNGVMEED EPLDLDLSLR L
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453579950.0
Expression AtlasAT5G14010-
AtGenExpressAT5G14010-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: First expressed in developing carpel primordia, and later in stamens and ovules of flower buds. {ECO:0000269|PubMed:15240552}.
Functional Description ? help Back to Top
Source Description
TAIREncodes KNUCKLES (KNU), a C2H2-type zinc finger protein with a conserved transcriptional repression motif. Mediates the repression of WUS in floral meristem determinacy control.
UniProtMay function as a transcriptional repressor of cellular proliferation that regulates floral determinacy and relative size of basal pattern elements along the proximo-distal axis of the developing gynoecium. {ECO:0000269|PubMed:15240552}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G14010.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT4G18960 (A)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT2G17950(R)
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G14010
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0052300.0AB005230.2 Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone:MAC12.
GenBankAY6126080.0AY612608.1 Arabidopsis thaliana KNUCKLES (KNU) mRNA, complete cds.
GenBankBT0247030.0BT024703.1 Arabidopsis thaliana At5g14010 mRNA, complete cds.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_196905.11e-117C2H2 and C2HC zinc fingers superfamily protein
SwissprotQ9FFX41e-118KNU_ARATH; Zinc finger protein KNUCKLES
TrEMBLA0A384L1F11e-116A0A384L1F1_ARATH; KNU
TrEMBLQ29Q531e-116Q29Q53_ARATH; At5g14010
STRINGAT5G14010.11e-116(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM69662031
Representative plantOGRP8215137
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Dal Bosco C, et al.
    Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.
    J. Biol. Chem., 2004. 279(2): p. 1060-9
    [PMID:14576160]
  3. Englbrecht CC,Schoof H,B
    Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.
    BMC Genomics, 2004. 5(1): p. 39
    [PMID:15236668]
  4. Payne T,Johnson SD,Koltunow AM
    KNUCKLES (KNU) encodes a C2H2 zinc-finger protein that regulates development of basal pattern elements of the Arabidopsis gynoecium.
    Development, 2004. 131(15): p. 3737-49
    [PMID:15240552]
  5. Wagner R,Pfannschmidt T
    Eukaryotic transcription factors in plastids--Bioinformatic assessment and implications for the evolution of gene expression machineries in plants.
    Gene, 2006. 381: p. 62-70
    [PMID:16934950]
  6. Ciftci-Yilmaz S,Mittler R
    The zinc finger network of plants.
    Cell. Mol. Life Sci., 2008. 65(7-8): p. 1150-60
    [PMID:18193167]
  7. Sun B,Xu Y,Ng KH,Ito T
    A timing mechanism for stem cell maintenance and differentiation in the Arabidopsis floral meristem.
    Genes Dev., 2009. 23(15): p. 1791-804
    [PMID:19651987]
  8. Liu X, et al.
    AGAMOUS terminates floral stem cell maintenance in Arabidopsis by directly repressing WUSCHEL through recruitment of Polycomb Group proteins.
    Plant Cell, 2011. 23(10): p. 3654-70
    [PMID:22028461]
  9. Sun B, et al.
    Timing mechanism dependent on cell division is invoked by Polycomb eviction in plant stem cells.
    Science, 2014. 343(6170): p. 1248559
    [PMID:24482483]
  10. Bollier N, et al.
    At-MINI ZINC FINGER2 and Sl-INHIBITOR OF MERISTEM ACTIVITY, a Conserved Missing Link in the Regulation of Floral Meristem Termination in Arabidopsis and Tomato.
    Plant Cell, 2018. 30(1): p. 83-100
    [PMID:29298836]