PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G13910.1
Common NameERF085, LEP, MAC12.13
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 211aa    MW: 23681 Da    PI: 4.8017
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G13910.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP261.22.3e-191968255
          AP2  2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55
                 ++ GVr+++ +gr++AeIrdp++   + r++lg+f+taeeAa a+++a+++++g
  AT5G13910.1 19 RFLGVRRRP-WGRYAAEIRDPTT---KERHWLGTFDTAEEAALAYDRAARSMRG 68
                 678******.**********965...5*************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000181.74E-311875No hitNo description
PROSITE profilePS5103220.7451976IPR001471AP2/ERF domain
SMARTSM003807.1E-341982IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.105.2E-292076IPR001471AP2/ERF domain
PRINTSPR003672.3E-82031IPR001471AP2/ERF domain
PfamPF008473.7E-122068IPR001471AP2/ERF domain
SuperFamilySSF541712.88E-212077IPR016177DNA-binding domain
PRINTSPR003672.3E-84258IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009739Biological Processresponse to gibberellin
GO:0009740Biological Processgibberellic acid mediated signaling pathway
GO:0009873Biological Processethylene-activated signaling pathway
GO:0010030Biological Processpositive regulation of seed germination
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000017anatomyvascular leaf primordium
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009025anatomyvascular leaf
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0007057developmental stageseed germination stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 211 aa     Download sequence    Send to blast
MNTTSSKSKK KQDDQVGTRF LGVRRRPWGR YAAEIRDPTT KERHWLGTFD TAEEAALAYD  60
RAARSMRGTR ARTNFVYSDM PPSSSVTSIV SPDDPPPPPP PPAPPSNDPV DYMMMFNQYS  120
STDSPMLQPH CDQVDSYMFG GSQSSNSYCY SNDSSNELPP LPSDLSNSCY SQPQWTWTGD  180
DYSSEYVHSP MFSRMPPVSD SFPQGFNYFG S
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2gcc_A1e-201775362ATERF1
3gcc_A1e-201775362ATERF1
Search in ModeBase
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO184172300.0
Genevisible250231_at0.0
Expression AtlasAT5G13910-
AtGenExpressAT5G13910-
ATTED-IIAT5G13910-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in germinating seeds. Present in young shoots, at low levels, especially in leaf primordia and developing leaf blades. Also detected in vascular tissue, mostly in xylem, of young leaves, petioles and hypocotyls. {ECO:0000269|PubMed:11044410, ECO:0000269|PubMed:12472696, ECO:0000269|PubMed:16339853}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family (LEAFY PETIOLE). The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and LEAFY PETIOLE. Acts as a positive regulator of gibberellic acid-induced germination.
UniProtCell division-promoting factor involved in leaf blade differentiation, inflorescence branching, as well as in carpel and silique shape. Promotes the number of xylem cells. Regulates positively the gibberellin signaling pathway leading to germination, hypocotyl elongation, and leaf expansion. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250, ECO:0000269|PubMed:11044410, ECO:0000269|PubMed:12472696, ECO:0000269|PubMed:16339853}.
Function -- GeneRIF ? help Back to Top
  1. LEP is a positive regulator of GA-induced germination acting independently of RGL2. [LEAFY PETIOLE] [LEP]
    [PMID: 16339853]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00509DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G13910.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By imbibition. {ECO:0000269|PubMed:16339853}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDgibberellin
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G13910
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0052300.0AB005230.2 Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone:MAC12.
GenBankAY5608520.0AY560852.1 Arabidopsis thaliana putative AP2/EREBP transcription factor (At5g13910) mRNA, complete cds.
GenBankBT0249190.0BT024919.1 Arabidopsis thaliana At5g13910 mRNA, complete cds.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_196895.11e-154Integrase-type DNA-binding superfamily protein
SwissprotQ9M6441e-155LEP_ARATH; Ethylene-responsive transcription factor LEP
TrEMBLA0A178UQP21e-152A0A178UQP2_ARATH; LEP
STRINGAT5G13910.11e-153(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM10281650
Representative plantOGRP6161718
Publications ? help Back to Top
  1. van der Graaff E,Dulk-Ras AD,Hooykaas PJ,Keller B
    Activation tagging of the LEAFY PETIOLE gene affects leaf petiole development in Arabidopsis thaliana.
    Development, 2000. 127(22): p. 4971-80
    [PMID:11044410]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. van der Graaff E,Hooykaas PJ,Keller B
    Activation tagging of the two closely linked genes LEP and VAS independently affects vascular cell number.
    Plant J., 2002. 32(5): p. 819-30
    [PMID:12472696]
  4. van der Graaff E,Nussbaumer C,Keller B
    The Arabidopsis thaliana rlp mutations revert the ectopic leaf blade formation conferred by activation tagging of the LEP gene.
    Mol. Genet. Genomics, 2003. 270(3): p. 243-52
    [PMID:12910411]
  5. Cluis CP,Mouchel CF,Hardtke CS
    The Arabidopsis transcription factor HY5 integrates light and hormone signaling pathways.
    Plant J., 2004. 38(2): p. 332-47
    [PMID:15078335]
  6. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  7. Ward JM, et al.
    A new role for the Arabidopsis AP2 transcription factor, LEAFY PETIOLE, in gibberellin-induced germination is revealed by the misexpression of a homologous gene, SOB2/DRN-LIKE.
    Plant Cell, 2006. 18(1): p. 29-39
    [PMID:16339853]
  8. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
    [PMID:16407444]
  9. Jung J, et al.
    The barley ERF-type transcription factor HvRAF confers enhanced pathogen resistance and salt tolerance in Arabidopsis.
    Planta, 2007. 225(3): p. 575-88
    [PMID:16937017]
  10. Lee DJ, et al.
    Genome-wide expression profiling of ARABIDOPSIS RESPONSE REGULATOR 7(ARR7) overexpression in cytokinin response.
    Mol. Genet. Genomics, 2007. 277(2): p. 115-37
    [PMID:17061125]
  11. Meinke DW
    A survey of dominant mutations in Arabidopsis thaliana.
    Trends Plant Sci., 2013. 18(2): p. 84-91
    [PMID:22995285]
  12. Chandler JW
    Class VIIIb APETALA2 Ethylene Response Factors in Plant Development.
    Trends Plant Sci., 2018. 23(2): p. 151-162
    [PMID:29074232]