PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G11260.1
Common NameBZIP56, F2I11_150, HY5, TED 5
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bZIP
Protein Properties Length: 168aa    MW: 18463.3 Da    PI: 10.194
Description bZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G11260.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1bZIP_151.22.8e-1686146161
                  XXXXCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       bZIP_1   1 ekelkrerrkqkNReAArrsRqRKkaeieeLeekvkeLeaeNkaLkkeleelkkevaklks 61 
                  eke kr +r+ +NR++A+  R+RKka++ eLe++vk Le++N++L ++l++l++e + l+ 
  AT5G11260.1  86 EKENKRLKRLLRNRVSAQQARERKKAYLSELENRVKDLENKNSELEERLSTLQNENQMLRH 146
                  7999****************************************************98865 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PRINTSPR000417.2E-785101IPR001630cAMP response element binding (CREB) protein
SMARTSM003381.5E-1486150IPR004827Basic-leucine zipper domain
PfamPF001702.4E-1486147IPR004827Basic-leucine zipper domain
PROSITE profilePS5021712.87588151IPR004827Basic-leucine zipper domain
Gene3DG3DSA:1.20.5.1702.1E-1790150No hitNo description
SuperFamilySSF579599.38E-1490148No hitNo description
CDDcd147043.38E-1591142No hitNo description
PROSITE patternPS00036093108IPR004827Basic-leucine zipper domain
PRINTSPR000417.2E-7103123IPR001630cAMP response element binding (CREB) protein
PRINTSPR000417.2E-7123140IPR001630cAMP response element binding (CREB) protein
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009585Biological Processred, far-red light phototransduction
GO:0009737Biological Processresponse to abscisic acid
GO:0009740Biological Processgibberellic acid mediated signaling pathway
GO:0010017Biological Processred or far-red light signaling pathway
GO:0010099Biological Processregulation of photomorphogenesis
GO:0010114Biological Processresponse to red light
GO:0010218Biological Processresponse to far red light
GO:0010224Biological Processresponse to UV-B
GO:0031539Biological Processpositive regulation of anthocyanin metabolic process
GO:0042753Biological Processpositive regulation of circadian rhythm
GO:0080167Biological Processresponse to karrikin
GO:0005634Cellular Componentnucleus
GO:0000977Molecular FunctionRNA polymerase II regulatory region sequence-specific DNA binding
GO:0003690Molecular Functiondouble-stranded DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000005anatomycultured plant cell
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 168 aa     Download sequence    Send to blast
MQEQATSSLA ASSLPSSSER SSSSAPHLEI KEGIESDEEI RRVPEFGGEA VGKETSGRES  60
GSATGQERTQ ATVGESQRKR GRTPAEKENK RLKRLLRNRV SAQQARERKK AYLSELENRV  120
KDLENKNSEL EERLSTLQNE NQMLRHILKN TTGNKRGGGG GSNADASL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2oqq_B2e-20111150342Transcription factor HY5
2oqq_A2e-20111150342Transcription factor HY5
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.202570.0flower| inflorescence| leaf| root| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1865220970.0
Genevisible250420_at0.0
Expression AtlasAT5G11260-
AtGenExpressAT5G11260-
ATTED-IIAT5G11260-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in root, hypocotyl, cotyledon, leaf, stem and floral organs.
Functional Description ? help Back to Top
Source Description
TAIRBasic leucine zipper (bZIP) transcription factor. Nuclear localization. Involved in light-regulated transcriptional activation of G-box-containing promoters. Negatively regulated by Cop1. Although cytokinins do not appear to affect the gene's promoter activity, they appear to stabilize the protein. HY5 plays a role in anthocyanin accumulation in far-red light and blue light, but not in red light or in the dark. Mutant studies showed that the gene product is involved in the positive regulation of the PHYA-mediated inhibition of hypocotyl elongation. Binds to G- and Z-boxes, and other ACEs, but not to E-box. Loss of function mutation shows ABA resistant seedling phenotypes suggesting involvement for HY5 in mediating ABA responses. Binds to the promoter of ABI5 and regulates its expression.
UniProtTranscription factor that promotes photomorphogenesis in light. Acts downstream of the light receptor network and directly affects transcription of light-induced genes. Specifically involved in the blue light specific pathway, suggesting that it participates in transmission of cryptochromes (CRY1 and CRY2) signals to downstream responses. In darkness, its degradation prevents the activation of light-induced genes.
Function -- GeneRIF ? help Back to Top
  1. the first structural and biophysical characterization of HY5 is reported here.
    [PMID: 17001643]
  2. The data support the hypothesis that the opposite root system phenotypes of hy5 single and hy5 hyh double mutants represent the morphological response to a quantitative gradient in the same molecular process.
    [PMID: 17121469]
  3. HY5 is a high hierarchical regulator of the transcriptional cascades for photomorphogenesis.
    [PMID: 17337630]
  4. necessary for high nitrate reductase expression in far-red light
    [PMID: 17929051]
  5. Gibberellins signaling regulates protein stability of HY5, and the activity of PIF3.
    [PMID: 18053005]
  6. This research provides evidence that, in ultraviolet B (UV-B) signaling, UVR8, HY5, and HYH act together and demonstrates a new role for HYH in UV-B responses.
    [PMID: 18055587]
  7. Data show that at part of the remodeling of light signaling networks involves converting HY5, a positive regulator of PhANGs, into a negative regulator of PhANGs.
    [PMID: 18065688]
  8. Arabidopsis HY5 functions as a novel DNA-binding tag (DBtag) for proteins. We also demonstrate that the DBtagged proteins could be immobilized and purified on a newly designed agarose/DNA microplate
    [PMID: 18082144]
  9. The isolation and characterization of light-regulated zinc finger protein 1 (LZF1), a HY5-regulated factor, is reported.
    [PMID: 18182030]
  10. Data show that there is a concerted function of CAM7 and HY5 basic leucine zipper transcription factor in Arabidopsis seedling development.
    [PMID: 18621945]
  11. HY5 and HYH were activators of NIA2, but inhibitors of NRT1.1 when tested across various light treatments and tissue types.
    [PMID: 19540016]
  12. action spectrum for the induction of HY5 by the UVR8 pathway showed a main peak at 280 nm with a smaller peak at 300 nm
    [PMID: 19558421]
  13. HY5 is required for the transcriptional activation of the PFG1/MYB12 and PFG3/MYB111 genes under UV-B and visible light.
    [PMID: 19895401]
  14. Det1 esp1 spa1 double mutant showed higher HY5 protein levels than either single mutant or the wild type.
    [PMID: 20041285]
  15. Data show that phosphorylation-mimicking serine substitutions strongly interfere with the DNA binding of two prototypical Arabidopsis bZIPs, namely AtZIP63 and HY5.
    [PMID: 20047775]
  16. HY5 directly binds to C/G-box and G-box in the HTL promoter and regulates the expression of HTL.
    [PMID: 20864454]
  17. HY5 and HYH are two necessary regulators that play a pivotal role during low temperature-induced anthocyanin accumulation in Arabidopsis seedlings.
    [PMID: 20932601]
  18. Data show that HY5 plays a role in negative feedback regulation of phyA signaling by attenuating FHY3/FAR1-activated FHY1/FHL expression, providing a mechanism for fine-tuning phyA signaling homeostasis.
    [PMID: 21097709]
  19. HY5 binds to over 9000 genes, detectably affecting the expression of over 1100 genes, either positively or negatively. HY5 indirectly regulate many other genes through sub-networks mediated by other regulators.
    [PMID: 21265889]
  20. The genetic interaction between HY5 and FRY1 indicates that HY5 and FRY1 may act in overlapping pathways that mediate light signaling and lateral root development.
    [PMID: 21301222]
  21. Analysis of BBX22 degradation kinetics shows that it has a short half-life under both dark and light conditions. COP1 mediates the BBX22 degradation in the dark. Although dispensable in the dark, HY5 contributes to the BBX22 degradation in the light.
    [PMID: 21427283]
  22. HY5 plays an important role in regulation of APR1 and APR2 gene expression and plant sulfate assimilation
    [PMID: 21623972]
  23. BBX32 interacts with SALT TOLERANCE HOMOLOG2/BBX21, another B-box protein previously shown to interact with HY5.
    [PMID: 21632973]
  24. Together with HY5/HYH, gibberellins signaling may play an important role during low temperature-induced anthocyanin accumulation.
    [PMID: 21636970]
  25. The HY5-AtERF11 regulon is a key factor modulating abscisic acid-regulated ethylene biosynthesis.
    [PMID: 21645149]
  26. light triggers MSBP1 expression through direct binding to and activation by HY5 and HYH.
    [PMID: 21715650]
  27. HY5 represses the expression of PKS4 and auxin-related genes.
    [PMID: 21848684]
  28. HSP90 proteins respond to the tetrapyrrole-mediated plastid signal to control expression of photosynthesis-associated nuclear genes
    [PMID: 22201048]
  29. HY5 and BBX24 act antagonistically in UV-B response.
    [PMID: 22410790]
  30. HY1 and HY5 additively regulate the expression of light regulated genes and accumulation of chlorophyll and anthocyanin during early seedling development.
    [PMID: 22424472]
  31. the functional interrelations of GBF1 with HY5 and HYH in Arabidopsis seedling development.
    [PMID: 22692212]
  32. Mediator component cooperates with COP1 in the regulation of light responses and that the hypersensitive seedling phenotype strictly depends on the presence of HY5, an important positive regulator of light-dependent gene expression.
    [PMID: 22760208]
  33. KAI2 and MAX2 define a regulatory pathway that largely operates independently of HY5 to mediate seedling responses to abiotic signals such as smoke and light.
    [PMID: 23142794]
  34. COP1 gene expression in response to photomorphogenic UV-B is controlled by a combinatorial regulation of FHY3 and HY5, and this UV-B-specific working mode of FHY3 and HY5 is distinct from that in far-red light and circadian conditions.
    [PMID: 23150635]
  35. PKL physically interacts with HY5 to directly regulate hypocotyl cell elongation by repressing trimethylation of histone H3 Lys 27 (H3K27me3) on the regulatory regions of several cell elongation- related genes in response to changing light conditions.
    [PMID: 23314848]
  36. HY5 transmits phyA signals through an FHY1/FHL-independent pathway but it may also modulate FHY1/FHL signal through its interaction with HFR1 and LAF1.
    [PMID: 23503597]
  37. Bifurcate regulation of anthocyanin biosynthesis by HY5 via transcriptional activation of PAP1.
    [PMID: 23583450]
  38. Data suggest that BBX25 (At2g31380) and BBX24 (At1g06040) function as transcriptional corepressors, probably by forming inactive heterodimers with HY5 (At5g11260) downregulating BBX22 (AT1G78600) expression for the light-mediated seedling development.
    [PMID: 23624715]
  39. Data indicate that the PIF1/PIF3-HY5/HYH transcriptional modules mediate crosstalk between light and ROS signaling and a mechanism by which plants adapt to the light environments.
    [PMID: 23645630]
  40. The DNA binding activity of GBF1 is modulated by heterodimeriation with HY5 and HYH.
    [PMID: 24157608]
  41. our investigation demonstrates that the COP1-HY5 complex is a novel integrator that plays an essential role in ethylene-promoted hypocotyl growth in the light
    [PMID: 24348273]
  42. COP1 inactivation involved in rapid light-induced responses were compared to that of nuclear HY5.
    [PMID: 24434030]
  43. A possible interplay between PFT1 and another transcription factor, HY5, may regulate induction of APS reductase expression by light.
    [PMID: 24583010]
  44. results demonstrate that CAM7 and HY5 directly interact with the HY5 promoter to mediate the transcriptional activity of HY5 during Arabidopsis seedling development
    [PMID: 24610722]
  45. by directly targeting a common promoter cis-element (G-box), HY5 and PIFs form a dynamic activation-suppression transcriptional module responsive to light and temperature cues.
    [PMID: 24922306]
  46. Ultraviolet-B causes unilateral accumulation of HY5, which then, in the end, leads to bending toward the light.
    [PMID: 25096978]
  47. Compromised activity of HY5 may have been mainly responsible for the partial reversal of the det1 phenotype in ted3 det1.
    [PMID: 25248106]
  48. Data indicate that the bZIP transcription factor ELONGATED HYPOCOTYL5 (HY5) is enriched at target promoters in response to UV-B in a UV RESISTANCE LOCUS8 (UVR8) photoreceptor-dependent manner.
    [PMID: 25351492]
  49. Investigated the root phenotype of cam7 hy5 double mutants and showed that CAM7 and HY5 genetically interact to control the root growth. We have further shown an interdependent function of HY5 and CAM7 in abscisic acid responsiveness.
    [PMID: 25763709]
  50. HY5 positively regulates nitrite reductase gene NIR1 and negatively regulates the ammonium transporter gene AMT1;2 under all nitrogen and light conditions tested.
    [PMID: 26259199]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00117ampDAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G11260.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT1G12110(R), AT1G12370(A), AT1G29920(A), AT1G29930(A), AT1G37130(A), AT1G58290(A), AT1G67090(A), AT1G78600(A), AT2G36270(A), AT2G37678(R), AT2G40080(A), AT2G47460(A), AT3G22840(A), AT3G23050(A), AT4G14550(A), AT4G15480(A), AT4G22880(A), AT4G32880(A), AT5G02200(R), AT5G13930(A), AT5G42800(A), ATCG00270(A)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDabscisic acid, gibberellin
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G11260, AT5G18450, AT5G19790, AT5G21960, AT5G46760, AT5G48560, AT5G57150, AT1G09530, AT1G25330, AT1G02340, AT1G56650, AT1G73870, AT1G75080, AT1G75540
IntActSearch O24646
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G11260
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0255190.0BT025519.1 Arabidopsis thaliana At5g11260 mRNA, complete cds.
GenBankAB0054560.0AB005456.1 Arabidopsis thaliana mRNA for HY5, complete cds.
GenBankAB0052950.0AB005295.1 Arabidopsis thaliana mRNA for HY5, complete cds.
GenBankAK2293620.0AK229362.1 Arabidopsis thaliana mRNA for bZip transcription factor HY5 / AtbZip56, complete cds, clone: RAFL16-60-N08.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_568246.11e-115transcription factor HY5
SwissprotO246461e-117HY5_ARATH; Transcription factor HY5
TrEMBLQ1H5E51e-115Q1H5E5_ARATH; At5g11260
STRINGAT5G11260.11e-114(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM56912749
Representative plantOGRP20811737
Publications ? help Back to Top
  1. Yamaguchi R,Nakamura M,Mochizuki N,Kay SA,Nagatani A
    Light-dependent translocation of a phytochrome B-GFP fusion protein to the nucleus in transgenic Arabidopsis.
    J. Cell Biol., 1999. 145(3): p. 437-45
    [PMID:10225946]
  2. Cao D,Lin Y,Cheng CL
    Genetic interactions between the chlorate-resistant mutant cr 8 8 and the photomorphogenic mutants cop1 and hy5.
    Plant Cell, 2000. 12(2): p. 199-210
    [PMID:10662857]
  3. Osterlund MT,Hardtke CS,Wei N,Deng XW
    Targeted destabilization of HY5 during light-regulated development of Arabidopsis.
    Nature, 2000. 405(6785): p. 462-6
    [PMID:10839542]
  4. Hardtke CS, et al.
    HY5 stability and activity in arabidopsis is regulated by phosphorylation in its COP1 binding domain.
    EMBO J., 2000. 19(18): p. 4997-5006
    [PMID:10990463]
  5. Riechmann JL,Ratcliffe OJ
    A genomic perspective on plant transcription factors.
    Curr. Opin. Plant Biol., 2000. 3(5): p. 423-34
    [PMID:11019812]
  6. Osterlund MT,Wei N,Deng XW
    The roles of photoreceptor systems and the COP1-targeted destabilization of HY5 in light control of Arabidopsis seedling development.
    Plant Physiol., 2000. 124(4): p. 1520-4
    [PMID:11115869]
  7. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  8. Schwechheimer C,Deng XW
    The COP/DET/FUS proteins-regulators of eukaryotic growth and development.
    Semin. Cell Dev. Biol., 2000. 11(6): p. 495-503
    [PMID:11145879]
  9. Guo H,Mockler T,Duong H,Lin C
    SUB1, an Arabidopsis Ca2+-binding protein involved in cryptochrome and phytochrome coaction.
    Science, 2001. 291(5503): p. 487-90
    [PMID:11161203]
  10. Holm M,Hardtke CS,Gaudet R,Deng XW
    Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1.
    EMBO J., 2001. 20(1-2): p. 118-27
    [PMID:11226162]
  11. Baima S, et al.
    The arabidopsis ATHB-8 HD-zip protein acts as a differentiation-promoting transcription factor of the vascular meristems.
    Plant Physiol., 2001. 126(2): p. 643-55
    [PMID:11402194]
  12. Wang H,Ma LG,Li JM,Zhao HY,Deng XW
    Direct interaction of Arabidopsis cryptochromes with COP1 in light control development.
    Science, 2001. 294(5540): p. 154-8
    [PMID:11509693]
  13. Pepper AE, et al.
    shl, a New set of Arabidopsis mutants with exaggerated developmental responses to available red, far-red, and blue light.
    Plant Physiol., 2001. 127(1): p. 295-304
    [PMID:11553757]
  14. Peng Z,Serino G,Deng XW
    A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3.
    Development, 2001. 128(21): p. 4277-88
    [PMID:11684663]
  15. Harari-Steinberg O,Ohad I,Chamovitz DA
    Dissection of the light signal transduction pathways regulating the two early light-induced protein genes in Arabidopsis.
    Plant Physiol., 2001. 127(3): p. 986-97
    [PMID:11706180]
  16. Thum KE,Kim M,Christopher DA,Mullet JE
    Cryptochrome 1, cryptochrome 2, and phytochrome a co-activate the chloroplast psbD blue light-responsive promoter.
    Plant Cell, 2001. 13(12): p. 2747-60
    [PMID:11752385]
  17. Malec P,Yahalom A,Chamovitz DA
    Identification of a light-regulated protein kinase activity from seedlings of Arabidopsis thaliana.
    Photochem. Photobiol., 2002. 75(2): p. 178-83
    [PMID:11883605]
  18. Jakoby M, et al.
    bZIP transcription factors in Arabidopsis.
    Trends Plant Sci., 2002. 7(3): p. 106-11
    [PMID:11906833]
  19. Oyama T,Shimura Y,Okada K
    The IRE gene encodes a protein kinase homologue and modulates root hair growth in Arabidopsis.
    Plant J., 2002. 30(3): p. 289-99
    [PMID:12000677]
  20. Holm M,Ma LG,Qu LJ,Deng XW
    Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis.
    Genes Dev., 2002. 16(10): p. 1247-59
    [PMID:12023303]
  21. Hardtke CS,Okamoto H,Stoop-Myer C,Deng XW
    Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8).
    Plant J., 2002. 30(4): p. 385-94
    [PMID:12028569]
  22. Kim YM,Woo JC,Song PS,Soh MS
    HFR1, a phytochrome A-signalling component, acts in a separate pathway from HY5, downstream of COP1 in Arabidopsis thaliana.
    Plant J., 2002. 30(6): p. 711-9
    [PMID:12061902]
  23. Yadav V, et al.
    Light regulated modulation of Z-box containing promoters by photoreceptors and downstream regulatory components, COP1 and HY5, in Arabidopsis.
    Plant J., 2002. 31(6): p. 741-53
    [PMID:12220265]
  24. Benvenuto G,Formiggini F,Laflamme P,Malakhov M,Bowler C
    The photomorphogenesis regulator DET1 binds the amino-terminal tail of histone H2B in a nucleosome context.
    Curr. Biol., 2002. 12(17): p. 1529-34
    [PMID:12225670]
  25. Somers DE,Sharrock RA,Tepperman JM,Quail PH
    The hy3 Long Hypocotyl Mutant of Arabidopsis Is Deficient in Phytochrome B.
    Plant Cell, 1991. 3(12): p. 1263-1274
    [PMID:12324590]
  26. Ma L, et al.
    Genomic evidence for COP1 as a repressor of light-regulated gene expression and development in Arabidopsis.
    Plant Cell, 2002. 14(10): p. 2383-98
    [PMID:12368493]
  27. Schwechheimer C,Serino G,Deng XW
    Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 function.
    Plant Cell, 2002. 14(10): p. 2553-63
    [PMID:12368504]
  28. Nishimura R,Ohmori M,Fujita H,Kawaguchi M
    A Lotus basic leucine zipper protein with a RING-finger motif negatively regulates the developmental program of nodulation.
    Proc. Natl. Acad. Sci. U.S.A., 2002. 99(23): p. 15206-10
    [PMID:12397181]
  29. McCormac AC,Terry MJ
    Light-signalling pathways leading to the co-ordinated expression of HEMA1 and Lhcb during chloroplast development in Arabidopsis thaliana.
    Plant J., 2002. 32(4): p. 549-59
    [PMID:12445126]
  30. Maxwell BB,Andersson CR,Poole DS,Kay SA,Chory J
    HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression.
    Plant Physiol., 2003. 133(4): p. 1565-77
    [PMID:14563928]
  31. Saijo Y, et al.
    The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity.
    Genes Dev., 2003. 17(21): p. 2642-7
    [PMID:14597662]
  32. Yang KY,Kim YM,Lee S,Song PS,Soh MS
    Overexpression of a mutant basic helix-loop-helix protein HFR1, HFR1-deltaN105, activates a branch pathway of light signaling in Arabidopsis.
    Plant Physiol., 2003. 133(4): p. 1630-42
    [PMID:14645731]
  33. Ulm R, et al.
    Genome-wide analysis of gene expression reveals function of the bZIP transcription factor HY5 in the UV-B response of Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2004. 101(5): p. 1397-402
    [PMID:14739338]
  34. Cluis CP,Mouchel CF,Hardtke CS
    The Arabidopsis transcription factor HY5 integrates light and hormone signaling pathways.
    Plant J., 2004. 38(2): p. 332-47
    [PMID:15078335]
  35. Bertrand C, et al.
    Arabidopsis HAF2 gene encoding TATA-binding protein (TBP)-associated factor TAF1, is required to integrate light signals to regulate gene expression and growth.
    J. Biol. Chem., 2005. 280(2): p. 1465-73
    [PMID:15525647]
  36. Jang IC,Yang JY,Seo HS,Chua NH
    HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling.
    Genes Dev., 2005. 19(5): p. 593-602
    [PMID:15741320]
  37. Yang J, et al.
    Repression of light signaling by Arabidopsis SPA1 involves post-translational regulation of HFR1 protein accumulation.
    Plant J., 2005. 43(1): p. 131-41
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