PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G06650.1
Common NameGIS2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 191aa    MW: 22465.8 Da    PI: 9.4395
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G06650.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H216.13.1e-055577123
                 EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2  1 ykCpdCgksFsrksnLkrHirtH 23
                 +kC++C + F+++  L  H++ H
  AT5G06650.1 55 FKCHYCFRNFPTSQALGGHQNAH 77
                 89******************988 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576671.43E-65182No hitNo description
PROSITE profilePS5015711.0115582IPR007087Zinc finger, C2H2
PROSITE patternPS0002805777IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007275Biological Processmulticellular organism development
GO:0009735Biological Processresponse to cytokinin
GO:0009739Biological Processresponse to gibberellin
GO:0010026Biological Processtrichome differentiation
GO:0003676Molecular Functionnucleic acid binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000229anatomyflower meristem
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009046anatomyflower
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007611developmental stagepetal differentiation and expansion stage
Sequence ? help Back to Top
Protein Sequence    Length: 191 aa     Download sequence    Send to blast
MKTYDFMNVN SFSPKERPIR LFGFEFGASH EESESKDNYN ENNESIKDDN KEKRFKCHYC  60
FRNFPTSQAL GGHQNAHKRE RQQTKRFNLH SNAAAFFHRQ QNHIAASRLY EDRYSLEAVQ  120
INDARLGLCR MYNSSASFNR DRSSYYNRYI PWFIGDHQTR PTYVGGGSSS HGLFYESKKN  180
VPDHVSLDLR L
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO184152750.0
Genevisible250684_at0.0
Expression AtlasAT5G06650-
AtGenExpressAT5G06650-
ATTED-IIAT5G06650-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in inflorescence meristems, floral meristems and stem epidermis. {ECO:0000269|PubMed:17507408}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin. Is not involved in the regulation of trichome branching. Is functionally equivalent to ZFP8. {ECO:0000269|PubMed:17507408}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G06650.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cytokinin and gibberellin. {ECO:0000269|PubMed:17507408}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT3G27920(A)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDcytokinin, gibberellin
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Reduced trichome production on cauline leaves, stem branches and sepals. {ECO:0000269|PubMed:17507408}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G06650
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAP0025430.0AP002543.1 Arabidopsis thaliana genomic DNA, chromosome 5, BAC clone:F15M7.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_196283.11e-143C2H2 and C2HC zinc fingers superfamily protein
SwissprotQ9FG051e-144GIS2_ARATH; Zinc finger protein GIS2
TrEMBLA0A178UCF61e-141A0A178UCF6_ARATH; GIS2
STRINGAT5G06650.11e-142(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM146591214
Representative plantOGRP285958
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Englbrecht CC,Schoof H,B
    Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.
    BMC Genomics, 2004. 5(1): p. 39
    [PMID:15236668]
  3. Gan Y,Liu C,Yu H,Broun P
    Integration of cytokinin and gibberellin signalling by Arabidopsis transcription factors GIS, ZFP8 and GIS2 in the regulation of epidermal cell fate.
    Development, 2007. 134(11): p. 2073-81
    [PMID:17507408]
  4. Gan Y,Yu H,Peng J,Broun P
    Genetic and molecular regulation by DELLA proteins of trichome development in Arabidopsis.
    Plant Physiol., 2007. 145(3): p. 1031-42
    [PMID:17704233]
  5. Ciftci-Yilmaz S,Mittler R
    The zinc finger network of plants.
    Cell. Mol. Life Sci., 2008. 65(7-8): p. 1150-60
    [PMID:18193167]
  6. Yu N, et al.
    Temporal control of trichome distribution by microRNA156-targeted SPL genes in Arabidopsis thaliana.
    Plant Cell, 2010. 22(7): p. 2322-35
    [PMID:20622149]
  7. Zhou Z, et al.
    Zinc finger protein5 is required for the control of trichome initiation by acting upstream of zinc finger protein8 in Arabidopsis.
    Plant Physiol., 2011. 157(2): p. 673-82
    [PMID:21803862]
  8. Zhou Z,An L,Sun L,Gan Y
    ZFP5 encodes a functionally equivalent GIS protein to control trichome initiation.
    Plant Signal Behav, 2012. 7(1): p. 28-30
    [PMID:22301962]
  9. Yan A,Pan J,An L,Gan Y,Feng H
    The responses of trichome mutants to enhanced ultraviolet-B radiation in Arabidopsis thaliana.
    J. Photochem. Photobiol. B, Biol., 2012. 113: p. 29-35
    [PMID:22647943]
  10. Zhou Z, et al.
    Zinc Finger Protein 6 (ZFP6) regulates trichome initiation by integrating gibberellin and cytokinin signaling in Arabidopsis thaliana.
    New Phytol., 2013. 198(3): p. 699-708
    [PMID:23506479]
  11. Sun L, et al.
    GLABROUS INFLORESCENCE STEMS3 (GIS3) regulates trichome initiation and development in Arabidopsis.
    New Phytol., 2015. 206(1): p. 220-30
    [PMID:25640859]
  12. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]
  13. Kim SY,Hyoung S,So WM,Shin JS
    The novel transcription factor TRP interacts with ZFP5, a trichome initiation-related transcription factor, and negatively regulates trichome initiation through gibberellic acid signaling.
    Plant Mol. Biol., 2018. 96(3): p. 315-326
    [PMID:29335898]