PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G04340.1
Common NameC2H2, CZF2, T19N18.70, ZAT6
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 238aa    MW: 25252.3 Da    PI: 8.152
Description zinc finger of Arabidopsis thaliana 6
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G04340.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
      zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                  ykC+ C+k Fs+   L  H  +H
                  9***********99999998887 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576675.87E-1088111No hitNo description
SMARTSM003550.007389111IPR015880Zinc finger, C2H2-like
PfamPF139121.8E-1389113IPR007087Zinc finger, C2H2
Gene3DG3DSA: finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.26389111IPR007087Zinc finger, C2H2
PROSITE patternPS00028091111IPR007087Zinc finger, C2H2
SuperFamilySSF576675.87E-10143170No hitNo description
SMARTSM003550.35148170IPR015880Zinc finger, C2H2-like
PfamPF139121.3E-11148172IPR007087Zinc finger, C2H2
PROSITE profilePS5015710.014148175IPR007087Zinc finger, C2H2
PROSITE patternPS000280150170IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010200Biological Processresponse to chitin
GO:0055062Biological Processphosphate ion homeostasis
GO:2000280Biological Processregulation of root development
GO:0005634Cellular Componentnucleus
GO:0001047Molecular Functioncore promoter binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0009025anatomyvascular leaf
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 238 aa     Download sequence    Send to blast
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.650290.0leaf| root| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT5G04340-
Functional Description ? help Back to Top
Source Description
TAIRputative c2h2 zinc finger transcription factor mRNA,
UniProtProbable transcription factor that regulates root development and phosphate (Pi) acquisition and homeostasis. Probably acts as a repressor of primary root growth and regulates Pi homeostasis through the control of root architecture. {ECO:0000269|PubMed:17631527}.
Function -- GeneRIF ? help Back to Top
  1. AtSWP1 and AtCZS (a C2H2 zinc finger-SET domain protein) represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
    [PMID: 17224141]
  2. repressor of primary root growth and regulates phosphate homeostasis through the control of root architecture
    [PMID: 17631527]
  3. these results suggest that phosphorylation by MPK6 is required for the functional role of ZAT6 in seed germination under salt and osmotic stress.
    [PMID: 23257164]
  4. ZAT6 coordinately activates phytochelatin synthesis-related gene expression and directly targets GSH1 to positively regulate Cd accumulation and tolerance in Arabidopsis.
    [PMID: 26983992]
  5. melatonin and auxin mediated the transcriptional levels of zinc finger of Arabidopsis thaliana (ZAT6) in a mutually antagonistic manner. ZAT6 negatively modulated the endogenous auxin level
    [PMID: 29607541]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cold treatment and during Pi starvation. {ECO:0000269|PubMed:15634197, ECO:0000269|PubMed:17631527}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G04340
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF0226580.0AF022658.1 Arabidopsis thaliana putative c2h2 zinc finger transcription factor mRNA, complete cds.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
SwissprotO225331e-174ZAT6_ARATH; Zinc finger protein ZAT6
STRINGAT5G04340.11e-172(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP13115149
Publications ? help Back to Top
  1. Chrispeels HE,Oettinger H,Janvier N,Tague BW
    AtZFP1, encoding Arabidopsis thaliana C2H2 zinc-finger protein 1, is expressed downstream of photomorphogenic activation.
    Plant Mol. Biol., 2000. 42(2): p. 279-90
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  3. Kim JC, et al.
    A novel cold-inducible zinc finger protein from soybean, SCOF-1, enhances cold tolerance in transgenic plants.
    Plant J., 2001. 25(3): p. 247-59
  4. Seki M, et al.
    Functional annotation of a full-length Arabidopsis cDNA collection.
    Science, 2002. 296(5565): p. 141-5
  5. Vogel JT,Zarka DG,Van Buskirk HA,Fowler SG,Thomashow MF
    Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis.
    Plant J., 2005. 41(2): p. 195-211
  6. Li P, et al.
    Effects of chronic ozone exposure on gene expression in Arabidopsis thaliana ecotypes and in Thellungiella halophila.
    Plant Cell Environ., 2006. 29(5): p. 854-68
  7. Krichevsky A, et al.
    C2H2 zinc finger-SET histone methyltransferase is a plant-specific chromatin modifier.
    Dev. Biol., 2007. 303(1): p. 259-69
  8. Gan Y,Liu C,Yu H,Broun P
    Integration of cytokinin and gibberellin signalling by Arabidopsis transcription factors GIS, ZFP8 and GIS2 in the regulation of epidermal cell fate.
    Development, 2007. 134(11): p. 2073-81
  9. Zhang J,Cao ML,Huang YB,Wu BJ
    [Study of hrpN(CSDS001) and the gene expression profile of Arabidopsis thaliana induced by Harpin(CSDS001)].
    Yi Chuan, 2007. 29(5): p. 629-36
  10. Crawford BC,Ditta G,Yanofsky MF
    The NTT gene is required for transmitting-tract development in carpels of Arabidopsis thaliana.
    Curr. Biol., 2007. 17(13): p. 1101-8
  11. Devaiah BN,Nagarajan VK,Raghothama KG
    Phosphate homeostasis and root development in Arabidopsis are synchronized by the zinc finger transcription factor ZAT6.
    Plant Physiol., 2007. 145(1): p. 147-59
  12. Ciftci-Yilmaz S,Mittler R
    The zinc finger network of plants.
    Cell. Mol. Life Sci., 2008. 65(7-8): p. 1150-60
  13. Pauwels L, et al.
    Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells.
    Proc. Natl. Acad. Sci. U.S.A., 2008. 105(4): p. 1380-5
  14. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
  15. Vald
    Transcriptional regulation and signaling in phosphorus starvation: what about legumes?
    J Integr Plant Biol, 2008. 50(10): p. 1213-22
  16. Kagale S,Links MG,Rozwadowski K
    Genome-wide analysis of ethylene-responsive element binding factor-associated amphiphilic repression motif-containing transcriptional regulators in Arabidopsis.
    Plant Physiol., 2010. 152(3): p. 1109-34
  17. Kodaira KS, et al.
    Arabidopsis Cys2/His2 zinc-finger proteins AZF1 and AZF2 negatively regulate abscisic acid-repressive and auxin-inducible genes under abiotic stress conditions.
    Plant Physiol., 2011. 157(2): p. 742-56
  18. Gaudinier A, et al.
    Enhanced Y1H assays for Arabidopsis.
    Nat. Methods, 2011. 8(12): p. 1053-5
  19. Causier B,Ashworth M,Guo W,Davies B
    The TOPLESS interactome: a framework for gene repression in Arabidopsis.
    Plant Physiol., 2012. 158(1): p. 423-38
  20. Liu XM, et al.
    Phosphorylation of the zinc finger transcriptional regulator ZAT6 by MPK6 regulates Arabidopsis seed germination under salt and osmotic stress.
    Biochem. Biophys. Res. Commun., 2013. 430(3): p. 1054-9
  21. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
  22. Shi H, et al.
    The Cysteine2/Histidine2-Type Transcription Factor ZINC FINGER OF ARABIDOPSIS THALIANA6 Modulates Biotic and Abiotic Stress Responses by Activating Salicylic Acid-Related Genes and C-REPEAT-BINDING FACTOR Genes in Arabidopsis.
    Plant Physiol., 2014. 165(3): p. 1367-1379
  23. Shi H,Chan Z
    The cysteine2/histidine2-type transcription factor ZINC FINGER OF ARABIDOPSIS THALIANA 6-activated C-REPEAT-BINDING FACTOR pathway is essential for melatonin-mediated freezing stress resistance in Arabidopsis.
    J. Pineal Res., 2014. 57(2): p. 185-91
  24. Chen J, et al.
    Zinc-Finger Transcription Factor ZAT6 Positively Regulates Cadmium Tolerance through the Glutathione-Dependent Pathway in Arabidopsis.
    Plant Physiol., 2016. 171(1): p. 707-19
  25. Song L, et al.
    A transcription factor hierarchy defines an environmental stress response network.
    Science, 2017.
  26. Li Y, et al.
    The C2H2 zinc-finger protein SlZF3 regulates AsA synthesis and salt tolerance by interacting with CSN5B.
    Plant Biotechnol. J., 2018. 16(6): p. 1201-1213
  27. Kim SY,Hyoung S,So WM,Shin JS
    The novel transcription factor TRP interacts with ZFP5, a trichome initiation-related transcription factor, and negatively regulates trichome initiation through gibberellic acid signaling.
    Plant Mol. Biol., 2018. 96(3): p. 315-326
  28. Shi H, et al.
    Zinc finger of Arabidopsis thaliana 6 is involved in melatonin-mediated auxin signaling through interacting INDETERMINATE DOMAIN15 and INDOLE-3-ACETIC ACID 17.
    J. Pineal Res., 2018. 65(2): p. e12494
  29. Shi H,Liu G,Wei Y,Chan Z
    The zinc-finger transcription factor ZAT6 is essential for hydrogen peroxide induction of anthocyanin synthesis in Arabidopsis.
    Plant Mol. Biol., 2018. 97(1-2): p. 165-176
  30. Tague BW,Goodman HM
    Characterization of a family of Arabidopsis zinc finger protein cDNAs.
    Plant Mol. Biol., 1995. 28(2): p. 267-79
  31. Tague BW,Gallant P,Goodman HM
    Expression analysis of an Arabidopsis C2H2 zinc finger protein gene.
    Plant Mol. Biol., 1996. 32(5): p. 785-96
  32. Meissner R,Michael AJ
    Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc finger protein genes and cDNAs.
    Plant Mol. Biol., 1997. 33(4): p. 615-24
  33. Luo M, et al.
    Genes controlling fertilization-independent seed development in Arabidopsis thaliana.
    Proc. Natl. Acad. Sci. U.S.A., 1999. 96(1): p. 296-301