PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G02470.3
Common NameDP2, DP2A, DPA, T22P11.60
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family E2F/DP
Protein Properties Length: 292aa    MW: 33038.5 Da    PI: 7.2385
Description Transcription factor DP
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G02470.3genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP757.4e-2451133371
      E2F_TDP   3 eksLrlltqkflklleksee.givtlnevakeLvse.................dvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  + +Lr+++ +   +++k e+ +i+t++eva+e++s+                 ++kn+rRR+YD+lNV++al++i++ +k+eirwkg
  AT5G02470.3  51 GGGLRQFSVM---VCQKLEAkKITTYKEVADEIISDfatikqnaekplneneyNEKNIRRRVYDALNVFMALDIIAR-DKKEIRWKG 133
                  6799999999...****9999********************************************************.*******98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PIRSFPIRSF0094044.6E-992290IPR015648Transcription factor DP
Gene3DG3DSA:1.10.10.105.0E-3646137IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.4E-2949133IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.6E-2052133IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.35E-1852134IPR011991Winged helix-turn-helix DNA-binding domain
CDDcd144581.32E-28140241IPR014889Transcription factor DP, C-terminal
SuperFamilySSF1440742.04E-38140282No hitNo description
SMARTSM011381.8E-52140292IPR014889Transcription factor DP, C-terminal
PfamPF087818.1E-33141264IPR014889Transcription factor DP, C-terminal
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006357Biological Processregulation of transcription from RNA polymerase II promoter
GO:0007049Biological Processcell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0000981Molecular FunctionRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677Molecular FunctionDNA binding
GO:0005515Molecular Functionprotein binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 292 aa     Download sequence    Send to blast
MSMEMELFVT PEKQRQHPSV SVEKTPVRRK LIVDDDSEIG SEKKGQSRTS GGGLRQFSVM  60
VCQKLEAKKI TTYKEVADEI ISDFATIKQN AEKPLNENEY NEKNIRRRVY DALNVFMALD  120
IIARDKKEIR WKGLPITCKK DVEEVKMDRN KVMSSVQKKA AFLKELREKV SSLESLMSRN  180
QEMVVKTQGP AEGFTLPFIL LETNPHAVVE IEISEDMQLV HLDFNSTPFS VHDDAYILKL  240
MQEQKQEQNR VSSSSSTHHQ SQHSSAHSSS SSCIASGTSG PVCWNSGSID TR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_B8e-2643135390PROTEIN (TRANSCRIPTION FACTOR DP-2)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.49410.0bud| flower| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO111256500.0
Genevisible251052_at0.0
Expression AtlasAT5G02470-
AtGenExpressAT5G02470-
ATTED-IIAT5G02470-
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Low expression at the G1/S transition and increases during the S phase. S/G2 transitions. {ECO:0000269|PubMed:11669580}.
UniprotTISSUE SPECIFICITY: Strongly expressed in the actively dividing tissues of the shoot apical meristem, young leaf primordia, the vascular tissues of the maturing leaf primordia and axillary buds. {ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
TAIRcore cell cycle genes
UniProtInvolved in the regulation of the G1/S transition. Increases the DNA binding and the transactivation activities of E2F proteins after heterodimerization. The complex DPA/E2FA promotes cell division and acts as a regulator of the endocycle. Positively regulates the activity of S phase-specific genes. {ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G02470.3
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by the transcription factor ERF114. {ECO:0000269|PubMed:23616605}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT2G29680(A), AT3G54180(A)
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G22220, AT1G47870
IntActSearch Q9FNY3
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G02470
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ3190270.0AJ319027.1 Arabidopsis thaliana partial mRNA for E2F dimerisation partner protein (dp2a gene).
GenBankAK1171350.0AK117135.1 Arabidopsis thaliana At5g02470 mRNA for putative DP-2 transcription factor, complete cds, clone: RAFL16-67-D16.
GenBankBT0052860.0BT005286.1 Arabidopsis thaliana At5g02470 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_195867.20.0Transcription factor DP
RefseqNP_851027.10.0Transcription factor DP
RefseqNP_851028.10.0Transcription factor DP
SwissprotQ9FNY30.0DPA_ARATH; Transcription factor-like protein DPA
TrEMBLA0A178ULD90.0A0A178ULD9_ARATH; DPA
STRINGAT5G02470.20.0(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Magyar Z,Atanassova A,De Veylder L,Rombauts S,Inzé D
    Characterization of two distinct DP-related genes from Arabidopsis thaliana.
    FEBS Lett., 2000. 486(1): p. 79-87
    [PMID:11108847]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. de Jager SM,Menges M,Bauer UM,Murra JA
    Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities.
    Plant Mol. Biol., 2001. 47(4): p. 555-68
    [PMID:11669580]
  4. Mariconti L, et al.
    The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants.
    J. Biol. Chem., 2002. 277(12): p. 9911-9
    [PMID:11786543]
  5. Kosugi S,Ohashi Y
    E2Ls, E2F-like repressors of Arabidopsis that bind to E2F sites in a monomeric form.
    J. Biol. Chem., 2002. 277(19): p. 16553-8
    [PMID:11867638]
  6. De Veylder L, et al.
    Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor.
    EMBO J., 2002. 21(6): p. 1360-8
    [PMID:11889041]
  7. Kosugi S,Ohashi Y
    Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation.
    Plant Physiol., 2002. 128(3): p. 833-43
    [PMID:11891240]
  8. Seki M, et al.
    Functional annotation of a full-length Arabidopsis cDNA collection.
    Science, 2002. 296(5565): p. 141-5
    [PMID:11910074]
  9. Kosugi S,Ohashi Y
    E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters.
    Plant J., 2002. 29(1): p. 45-59
    [PMID:12060226]
  10. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  11. Vlieghe K, et al.
    The DP-E2F-like gene DEL1 controls the endocycle in Arabidopsis thaliana.
    Curr. Biol., 2005. 15(1): p. 59-63
    [PMID:15649366]
  12. Magyar Z, et al.
    The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division.
    Plant Cell, 2005. 17(9): p. 2527-41
    [PMID:16055635]
  13. Vandepoele K, et al.
    Genome-wide identification of potential plant E2F target genes.
    Plant Physiol., 2005. 139(1): p. 316-28
    [PMID:16126853]
  14. Yoshizumi T, et al.
    Increased level of polyploidy1, a conserved repressor of CYCLINA2 transcription, controls endoreduplication in Arabidopsis.
    Plant Cell, 2006. 18(10): p. 2452-68
    [PMID:17012601]
  15. Gusti A, et al.
    The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development.
    PLoS ONE, 2009. 4(3): p. e4780
    [PMID:19277118]
  16. Boruc J, et al.
    Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network.
    Plant Cell, 2010. 22(4): p. 1264-80
    [PMID:20407024]
  17. Henriques R, et al.
    Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1-E2F pathway activity.
    EMBO J., 2010. 29(17): p. 2979-93
    [PMID:20683442]
  18. Van Leene J, et al.
    Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.
    Mol. Syst. Biol., 2010. 6: p. 397
    [PMID:20706207]
  19. Elrouby N,Coupland G
    Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes.
    Proc. Natl. Acad. Sci. U.S.A., 2010. 107(40): p. 17415-20
    [PMID:20855607]
  20. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  21. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  22. Mehrnia M,Balazadeh S,Zanor MI,Mueller-Roeber B
    EBE, an AP2/ERF transcription factor highly expressed in proliferating cells, affects shoot architecture in Arabidopsis.
    Plant Physiol., 2013. 162(2): p. 842-57
    [PMID:23616605]
  23. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]