PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G02470.3
Common NameDP2, DP2A, DPA, T22P11.60
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family E2F/DP
Protein Properties Length: 292aa    MW: 33038.5 Da    PI: 7.2385
Description Transcription factor DP
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G02470.3genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
      E2F_TDP   3 eksLrlltqkflklleksee.givtlnevakeLvse.................dvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  + +Lr+++ +   +++k e+ +i+t++eva+e++s+                 ++kn+rRR+YD+lNV++al++i++ +k+eirwkg
                  6799999999...****9999********************************************************.*******98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PIRSFPIRSF0094044.6E-992290IPR015648Transcription factor DP
Gene3DG3DSA: helix-turn-helix DNA-binding domain
SMARTSM013724.4E-2949133IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.6E-2052133IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.35E-1852134IPR011991Winged helix-turn-helix DNA-binding domain
CDDcd144581.32E-28140241IPR014889Transcription factor DP, C-terminal
SuperFamilySSF1440742.04E-38140282No hitNo description
SMARTSM011381.8E-52140292IPR014889Transcription factor DP, C-terminal
PfamPF087818.1E-33141264IPR014889Transcription factor DP, C-terminal
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006357Biological Processregulation of transcription from RNA polymerase II promoter
GO:0007049Biological Processcell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0000981Molecular FunctionRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677Molecular FunctionDNA binding
GO:0005515Molecular Functionprotein binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009025anatomyvascular leaf
PO:0009052anatomyflower pedicel
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 292 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.49410.0bud| flower| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT5G02470-
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Low expression at the G1/S transition and increases during the S phase. S/G2 transitions. {ECO:0000269|PubMed:11669580}.
UniprotTISSUE SPECIFICITY: Strongly expressed in the actively dividing tissues of the shoot apical meristem, young leaf primordia, the vascular tissues of the maturing leaf primordia and axillary buds. {ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
TAIRcore cell cycle genes
UniProtInvolved in the regulation of the G1/S transition. Increases the DNA binding and the transactivation activities of E2F proteins after heterodimerization. The complex DPA/E2FA promotes cell division and acts as a regulator of the endocycle. Positively regulates the activity of S phase-specific genes. {ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240}.
Cis-element ? help Back to Top
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by the transcription factor ERF114. {ECO:0000269|PubMed:23616605}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT2G29680(A), AT3G54180(A)
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G22220, AT1G47870
IntActSearch Q9FNY3
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G02470
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ3190270.0AJ319027.1 Arabidopsis thaliana partial mRNA for E2F dimerisation partner protein (dp2a gene).
GenBankAK1171350.0AK117135.1 Arabidopsis thaliana At5g02470 mRNA for putative DP-2 transcription factor, complete cds, clone: RAFL16-67-D16.
GenBankBT0052860.0BT005286.1 Arabidopsis thaliana At5g02470 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_195867.20.0Transcription factor DP
RefseqNP_851027.10.0Transcription factor DP
RefseqNP_851028.10.0Transcription factor DP
SwissprotQ9FNY30.0DPA_ARATH; Transcription factor-like protein DPA
STRINGAT5G02470.20.0(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Magyar Z,Atanassova A,De Veylder L,Rombauts S,Inzé D
    Characterization of two distinct DP-related genes from Arabidopsis thaliana.
    FEBS Lett., 2000. 486(1): p. 79-87
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  3. de Jager SM,Menges M,Bauer UM,Murra JA
    Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities.
    Plant Mol. Biol., 2001. 47(4): p. 555-68
  4. Mariconti L, et al.
    The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants.
    J. Biol. Chem., 2002. 277(12): p. 9911-9
  5. Kosugi S,Ohashi Y
    E2Ls, E2F-like repressors of Arabidopsis that bind to E2F sites in a monomeric form.
    J. Biol. Chem., 2002. 277(19): p. 16553-8
  6. De Veylder L, et al.
    Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor.
    EMBO J., 2002. 21(6): p. 1360-8
  7. Kosugi S,Ohashi Y
    Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation.
    Plant Physiol., 2002. 128(3): p. 833-43
  8. Seki M, et al.
    Functional annotation of a full-length Arabidopsis cDNA collection.
    Science, 2002. 296(5565): p. 141-5
  9. Kosugi S,Ohashi Y
    E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters.
    Plant J., 2002. 29(1): p. 45-59
  10. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  11. Vlieghe K, et al.
    The DP-E2F-like gene DEL1 controls the endocycle in Arabidopsis thaliana.
    Curr. Biol., 2005. 15(1): p. 59-63
  12. Magyar Z, et al.
    The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division.
    Plant Cell, 2005. 17(9): p. 2527-41
  13. Vandepoele K, et al.
    Genome-wide identification of potential plant E2F target genes.
    Plant Physiol., 2005. 139(1): p. 316-28
  14. Yoshizumi T, et al.
    Increased level of polyploidy1, a conserved repressor of CYCLINA2 transcription, controls endoreduplication in Arabidopsis.
    Plant Cell, 2006. 18(10): p. 2452-68
  15. Gusti A, et al.
    The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development.
    PLoS ONE, 2009. 4(3): p. e4780
  16. Boruc J, et al.
    Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network.
    Plant Cell, 2010. 22(4): p. 1264-80
  17. Henriques R, et al.
    Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1-E2F pathway activity.
    EMBO J., 2010. 29(17): p. 2979-93
  18. Van Leene J, et al.
    Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.
    Mol. Syst. Biol., 2010. 6: p. 397
  19. Elrouby N,Coupland G
    Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes.
    Proc. Natl. Acad. Sci. U.S.A., 2010. 107(40): p. 17415-20
  20. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
  21. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
  22. Mehrnia M,Balazadeh S,Zanor MI,Mueller-Roeber B
    EBE, an AP2/ERF transcription factor highly expressed in proliferating cells, affects shoot architecture in Arabidopsis.
    Plant Physiol., 2013. 162(2): p. 842-57
  23. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73