PlantTFDB
Plant Transcription Factor Database
v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G37850.1
Common NameBHLH25, EN29, T28I19.130
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 328aa    MW: 37702.8 Da    PI: 6.4541
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G37850.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH37.35e-12152198455
                  HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                   h ++Er+RR+++ ++f  L  l+P +     kK++Ka++L  A ++Ik+Lq
  AT4G37850.1 152 DHIIAERKRREKLTQRFVALSALVPGL-----KKMDKASVLGDALKHIKYLQ 198
                  699************************.....9******************9 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088814.983148197IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000108.1E-10152198IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.3E-16152213IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474597.98E-17153217IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.15E-11153201No hitNo description
SMARTSM003537.7E-14154203IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 328 aa     Download sequence    Send to blast
MSILSTRWFS EQEIEENSII QQFHMNSIVG EVQEAQYIFP HSFTTNNDPS YDDLIEMKPP  60
KILETTYISP SSHLPPNSKP HHIHRHSSSR ILSFEDYGSN DMEHEYSPTY LNSIFSPKLE  120
AQVQPHQKSD EFNRKGTKRA QPFSRNQSNA QDHIIAERKR REKLTQRFVA LSALVPGLKK  180
MDKASVLGDA LKHIKYLQER VGELEEQKKE RRLESMVLVK KSKLILDDNN QSFSSSCEDG  240
FSDLDLPEIE VRFSDEDVLI KILCEKQKGH LAKIMAEIEK LHILITNSSV LNFGPTLDIT  300
IIAKKESDFD MTLMDVVKSL RSALSNFI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A6e-13152208864Transcription factor MYC2
5gnj_B6e-13152208864Transcription factor MYC2
5gnj_E6e-13152208864Transcription factor MYC2
5gnj_F6e-13152208864Transcription factor MYC2
5gnj_G6e-13152208864Transcription factor MYC2
5gnj_I6e-13152208864Transcription factor MYC2
5gnj_M6e-13152208864Transcription factor MYC2
5gnj_N6e-13152208864Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1156161ERKRRE
2157162RKRREK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.312230.0root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306916010.0
Genevisible253070_at0.0
Expression AtlasAT4G37850-
AtGenExpressAT4G37850-
ATTED-IIAT4G37850-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in flowers. {ECO:0000269|PubMed:12679534}.
Function -- GeneRIF ? help Back to Top
  1. Two Arabidopsis basic helix-loop-helix transcription factors bHLH25 and bHLH27 positively influence cyst nematode parasitism.
    [PMID: 21223395]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT4G37850.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By ethylene (ACC) and jasmonic acid (JA) treatments. {ECO:0000269|PubMed:12679534}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G37850
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4885670.0AF488567.1 Arabidopsis thaliana clone bHLH025 putative bHLH transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001329767.10.0basic helix-loop-helix (bHLH) DNA-binding superfamily protein
RefseqNP_195498.30.0basic helix-loop-helix (bHLH) DNA-binding superfamily protein
SwissprotQ9T0720.0BH025_ARATH; Transcription factor bHLH25
TrEMBLA0A178UTY60.0A0A178UTY6_ARATH; Uncharacterized protein
STRINGAT4G37850.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM49227146
Representative plantOGRP6561573
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  3. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  4. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  5. Stepanova AN,Yun J,Likhacheva AV,Alonso JM
    Multilevel interactions between ethylene and auxin in Arabidopsis roots.
    Plant Cell, 2007. 19(7): p. 2169-85
    [PMID:17630276]
  6. Chini A, et al.
    The JAZ family of repressors is the missing link in jasmonate signalling.
    Nature, 2007. 448(7154): p. 666-71
    [PMID:17637675]
  7. Jin J,Hewezi T,Baum TJ
    The Arabidopsis bHLH25 and bHLH27 transcription factors contribute to susceptibility to the cyst nematode Heterodera schachtii.
    Plant J., 2011. 65(2): p. 319-28
    [PMID:21223395]
  8. Tominaga-Wada R,Iwata M,Nukumizu Y,Wada T
    Analysis of IIId, IIIe and IVa group basic-helix-loop-helix proteins expressed in Arabidopsis root epidermis.
    Plant Sci., 2011. 181(4): p. 471-8
    [PMID:21889054]