PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G24240.1
Common NameATWRKY7, T22A6.70, WRKY7
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family WRKY
Protein Properties Length: 353aa    MW: 38349.2 Da    PI: 10.1492
Description WRKY DNA-binding protein 7
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G24240.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRKY96.41.9e-30281339259
                  --SS-EEEEEEE--TT-SS-EEEEEE-ST.T---EEEEEE-SSSTTEEEEEEES--SS- CS
         WRKY   2 dDgynWrKYGqKevkgsefprsYYrCtsa.gCpvkkkversaedpkvveitYegeHnhe 59 
                  +D+++WrKYGqK++kgs++pr+YY+C+s  gCp++k+ver+ +d  ++++tYeg+Hnh 
  AT4G24240.1 281 SDEFSWRKYGQKPIKGSPHPRGYYKCSSVrGCPARKHVERALDDAMMLIVTYEGDHNHA 339
                  69*************************988****************************6 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF105333.8E-16245278IPR018872Zn-cluster domain
Gene3DG3DSA:2.20.25.802.0E-32268339IPR003657WRKY domain
PROSITE profilePS5081129.872275341IPR003657WRKY domain
SuperFamilySSF1182901.44E-25278339IPR003657WRKY domain
SMARTSM007745.9E-37280340IPR003657WRKY domain
PfamPF031065.8E-26282338IPR003657WRKY domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005516Molecular Functioncalmodulin binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 353 aa     Download sequence    Send to blast
MTVELMMSSY SGGGGGGDGF PAIAAAAKME DTALREAASA GIHGVEEFLK LIGQSQQPTE  60
KSQTEITAVT DVAVNSFKKV ISLLGRSRTG HARFRRAPAS TQTPFKQTPV VEEEVEVEEK  120
KPETSSVLTK QKTEQYHGGG SAFRVYCPTP IHRRPPLSHN NNNNQNQTKN GSSSSSPPML  180
ANGAPSTINF APSPPVSATN SFMSSHRCDT DSTHMSSGFE FTNPSQLSGS RGKPPLSSAS  240
LKRRCNSSPS SRCHCSKKRK SRVKRVIRVP AVSSKMADIP SDEFSWRKYG QKPIKGSPHP  300
RGYYKCSSVR GCPARKHVER ALDDAMMLIV TYEGDHNHAL VLETTTMNHD KTL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2ayd_A1e-21268340273WRKY transcription factor 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1241259KRRCNSSPSSRCHCSKKRK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.209460.0leaf| root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO425670950.0
Genevisible254159_at0.0
Expression AtlasAT4G24240-
AtGenExpressAT4G24240-
ATTED-IIAT4G24240-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: In young, mature and senescent leaves. {ECO:0000269|PubMed:11722756}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a Ca-dependent calmodulin binding protein. Sequence similarity to the WRKY transcription factor gene family.
UniProtTranscription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. Ca(2+)-dependent Calmodulin-binding domain of AtWRKY7 is a conserved structural motif (C-motif) found in group IId of the WRKY protein family
    [PMID: 15733871]
  2. Pathogen-induced WRKY7 transcription factor plays a negative role in defense responses to P. syringae.
    [PMID: 16963526]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00450DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT4G24240.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By salicylic acid and strongly during leaf senescence. {ECO:0000269|PubMed:11449049, ECO:0000269|PubMed:11722756}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT3G56400 (R)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT2G14610(R)
Interaction ? help Back to Top
Source Intact With
IntActSearch Q9STX0
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G24240
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0964900.0AY096490.1 Arabidopsis thaliana putative DNA-binding protein (At4g24240) mRNA, complete cds.
GenBankAY0721510.0AY072151.1 Arabidopsis thaliana putative DNA-binding protein (At4g24240) mRNA, complete cds.
GenBankAF2727460.0AF272746.1 Arabidopsis thaliana WRKY DNA-binding protein 7 (WRKY7) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_194155.10.0WRKY transcription factor-like calmodulin binding protein
SwissprotQ9STX00.0WRKY7_ARATH; Probable WRKY transcription factor 7
TrEMBLD7M8W30.0D7M8W3_ARALL; WRKY DNA-binding protein 7
STRINGAT4G24240.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP8844615
MalvidsOGEM17152887
Publications ? help Back to Top
  1. Eulgem T,Rushton PJ,Robatzek S,Somssich IE
    The WRKY superfamily of plant transcription factors.
    Trends Plant Sci., 2000. 5(5): p. 199-206
    [PMID:10785665]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. Yu D,Chen C,Chen Z
    Evidence for an important role of WRKY DNA binding proteins in the regulation of NPR1 gene expression.
    Plant Cell, 2001. 13(7): p. 1527-40
    [PMID:11449049]
  4. Robatzek S,Somssich IE
    A new member of the Arabidopsis WRKY transcription factor family, AtWRKY6, is associated with both senescence- and defence-related processes.
    Plant J., 2001. 28(2): p. 123-33
    [PMID:11722756]
  5. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  6. Hoth S, et al.
    Monitoring genome-wide changes in gene expression in response to endogenous cytokinin reveals targets in Arabidopsis thaliana.
    FEBS Lett., 2003. 554(3): p. 373-80
    [PMID:14623097]
  7. Navarro L, et al.
    The transcriptional innate immune response to flg22. Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis.
    Plant Physiol., 2004. 135(2): p. 1113-28
    [PMID:15181213]
  8. Sottosanto JB,Gelli A,Blumwald E
    DNA array analyses of Arabidopsis thaliana lacking a vacuolar Na+/H+ antiporter: impact of AtNHX1 on gene expression.
    Plant J., 2004. 40(5): p. 752-71
    [PMID:15546358]
  9. Park CY, et al.
    WRKY group IId transcription factors interact with calmodulin.
    FEBS Lett., 2005. 579(6): p. 1545-50
    [PMID:15733871]
  10. Phelps-Durr TL,Thomas J,Vahab P,Timmermans MC
    Maize rough sheath2 and its Arabidopsis orthologue ASYMMETRIC LEAVES1 interact with HIRA, a predicted histone chaperone, to maintain knox gene silencing and determinacy during organogenesis.
    Plant Cell, 2005. 17(11): p. 2886-98
    [PMID:16243907]
  11. Truman W,de Zabala MT,Grant M
    Type III effectors orchestrate a complex interplay between transcriptional networks to modify basal defence responses during pathogenesis and resistance.
    Plant J., 2006. 46(1): p. 14-33
    [PMID:16553893]
  12. Thilmony R,Underwood W,He SY
    Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7.
    Plant J., 2006. 46(1): p. 34-53
    [PMID:16553894]
  13. Michel K,Abderhalden O,Bruggmann R,Dudler R
    Transcriptional changes in powdery mildew infected wheat and Arabidopsis leaves undergoing syringolin-triggered hypersensitive cell death at infection sites.
    Plant Mol. Biol., 2006. 62(4-5): p. 561-78
    [PMID:16941219]
  14. Kim KC,Fan B,Chen Z
    Pathogen-induced Arabidopsis WRKY7 is a transcriptional repressor and enhances plant susceptibility to Pseudomonas syringae.
    Plant Physiol., 2006. 142(3): p. 1180-92
    [PMID:16963526]
  15. Journot-Catalino N,Somssich IE,Roby D,Kroj T
    The transcription factors WRKY11 and WRKY17 act as negative regulators of basal resistance in Arabidopsis thaliana.
    Plant Cell, 2006. 18(11): p. 3289-302
    [PMID:17114354]
  16. Qutob D, et al.
    Phytotoxicity and innate immune responses induced by Nep1-like proteins.
    Plant Cell, 2006. 18(12): p. 3721-44
    [PMID:17194768]
  17. Chawade A,Br
    Putative cold acclimation pathways in Arabidopsis thaliana identified by a combined analysis of mRNA co-expression patterns, promoter motifs and transcription factors.
    BMC Genomics, 2007. 8: p. 304
    [PMID:17764576]
  18. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  19. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]