PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G18880.1
Common NameAT-HSFA4A, F13C5.50, HSF15, HSF21, HSFA4A, HSF A4A
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family HSF
Protein Properties Length: 401aa    MW: 46244.6 Da    PI: 5.1675
Description heat shock transcription factor A4A
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G18880.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind110.11.6e-34161072102
                   HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXXX CS
  HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkellekik 98 
                   Fl+k+ye+++d++ ++++sws++++sf+v+++ ef++++Lp++Fkh+nf+SF+RQLn+YgF+k + e+         weF+++ F +g+ +l+++i+
   AT4G18880.1  16 FLTKTYEMVDDSSSDSIVSWSQSNKSFIVWNPPEFSRDLLPRFFKHNNFSSFIRQLNTYGFRKADPEQ---------WEFANDDFVRGQPHLMKNIH 103
                   9**************************************************************99988.........******************** PP

                   XXXX CS
  HSF_DNA-bind  99 rkks 102
                   r+k 
   AT4G18880.1 104 RRKP 107
                   *985 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF467854.08E-3511105IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM004157.6E-6312105IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene3DG3DSA:1.10.10.101.3E-3713105IPR011991Winged helix-turn-helix DNA-binding domain
PRINTSPR000565.3E-191639IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004476.0E-3116105IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000565.3E-195466IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000565.3E-196779IPR000232Heat shock factor (HSF)-type, DNA-binding
SuperFamilySSF581137.06E-596187No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000302Biological Processresponse to reactive oxygen species
GO:0010200Biological Processresponse to chitin
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005737Cellular Componentcytoplasm
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0042803Molecular Functionprotein homodimerization activity
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 401 aa     Download sequence    Send to blast
MDENNHGVSS SSLPPFLTKT YEMVDDSSSD SIVSWSQSNK SFIVWNPPEF SRDLLPRFFK  60
HNNFSSFIRQ LNTYGFRKAD PEQWEFANDD FVRGQPHLMK NIHRRKPVHS HSLPNLQAQL  120
NPLTDSERVR MNNQIERLTK EKEGLLEELH KQDEEREVFE MQVKELKERL QHMEKRQKTM  180
VSFVSQVLEK PGLALNLSPC VPETNERKRR FPRIEFFPDE PMLEENKTCV VVREEGSTSP  240
SSHTREHQVE QLESSIAIWE NLVSDSCESM LQSRSMMTLD VDESSTFPES PPLSCIQLSV  300
DSRLKSPPSP RIIDMNCEPD GSKEQNTVAA PPPPPVAGAN DGFWQQFFSE NPGSTEQREV  360
QLERKDDKDK AGVRTEKCWW NSRNVNAITE QLGHLTSSER S
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5d5u_B7e-231110524129Heat shock factor protein 1
5d5v_B7e-231110524129Heat shock factor protein 1
5d5v_D7e-231110524129Heat shock factor protein 1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.19510.0flower| leaf
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible254592_at0.0
Expression AtlasAT4G18880-
AtGenExpressAT4G18880-
ATTED-IIAT4G18880-
Functional Description ? help Back to Top
Source Description
TAIRmember of Heat Stress Transcription Factor (Hsf) family
UniProtTranscriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Function -- GeneRIF ? help Back to Top
  1. HSFA4A is a substrate of the MPK3/MPK6 signaling and that it regulates stress responses in Arabidopsis.
    [PMID: 24676858]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00443DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT4G18880.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Interaction ? help Back to Top
Source Intact With
BioGRIDAT4G18880
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G18880
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0010490.0BT001049.1 Arabidopsis thaliana At4g18880/F13C5_50 mRNA, complete cds.
GenBankAY1255120.0AY125512.1 Arabidopsis thaliana AT4g18880/F13C5_50 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_193623.10.0heat stress transcription factor A-4a
SwissprotO494030.0HFA4A_ARATH; Heat stress transcription factor A-4a
TrEMBLD7M9D80.0D7M9D8_ARALL; AT-HSFA4A
STRINGAT4G18880.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP52351020
MalvidsOGEM28532868
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Nover L, et al.
    Arabidopsis and the heat stress transcription factor world: how many heat stress transcription factors do we need?
    Cell Stress Chaperones, 2001. 6(3): p. 177-89
    [PMID:11599559]
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  4. Hass C, et al.
    The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis.
    EMBO J., 2004. 23(16): p. 3290-302
    [PMID:15282545]
  5. Davletova S,Schlauch K,Coutu J,Mittler R
    The zinc-finger protein Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis.
    Plant Physiol., 2005. 139(2): p. 847-56
    [PMID:16183833]
  6. Xin Z,Zhao Y,Zheng ZL
    Transcriptome analysis reveals specific modulation of abscisic acid signaling by ROP10 small GTPase in Arabidopsis.
    Plant Physiol., 2005. 139(3): p. 1350-65
    [PMID:16258012]
  7. Ma S,Bohnert HJ
    Integration of Arabidopsis thaliana stress-related transcript profiles, promoter structures, and cell-specific expression.
    Genome Biol., 2007. 8(4): p. R49
    [PMID:17408486]
  8. Kusnierczyk A, et al.
    Transcriptional responses of Arabidopsis thaliana ecotypes with different glucosinolate profiles after attack by polyphagous Myzus persicae and oligophagous Brevicoryne brassicae.
    J. Exp. Bot., 2007. 58(10): p. 2537-52
    [PMID:17545220]
  9. Libault M,Wan J,Czechowski T,Udvardi M,Stacey G
    Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor.
    Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11
    [PMID:17722694]
  10. Chawade A,Br
    Putative cold acclimation pathways in Arabidopsis thaliana identified by a combined analysis of mRNA co-expression patterns, promoter motifs and transcription factors.
    BMC Genomics, 2007. 8: p. 304
    [PMID:17764576]
  11. Guo J, et al.
    Genome-wide analysis of heat shock transcription factor families in rice and Arabidopsis.
    J Genet Genomics, 2008. 35(2): p. 105-18
    [PMID:18407058]
  12. Huang D,Wu W,Abrams SR,Cutler AJ
    The relationship of drought-related gene expression in Arabidopsis thaliana to hormonal and environmental factors.
    J. Exp. Bot., 2008. 59(11): p. 2991-3007
    [PMID:18552355]
  13. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  14. Yuan J, et al.
    In silico comparison of transcript abundances during Arabidopsis thaliana and Glycine max resistance to Fusarium virguliforme.
    BMC Genomics, 2008. 9 Suppl 2: p. S6
    [PMID:18831797]
  15. P
    The heat shock factor A4A confers salt tolerance and is regulated by oxidative stress and the mitogen-activated protein kinases MPK3 and MPK6.
    Plant Physiol., 2014. 165(1): p. 319-34
    [PMID:24676858]
  16. Nover L, et al.
    The Hsf world: classification and properties of plant heat stress transcription factors.
    Cell Stress Chaperones, 1996. 1(4): p. 215-23
    [PMID:9222607]