PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G17490.1
Common NameATERF6, dl4780c, ERF103, ERF6, ERF-6, ERF-6-6, FCAALL.120
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 282aa    MW: 32108.3 Da    PI: 4.9266
Description ethylene responsive element binding factor 6
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G17490.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP256.85.4e-18136186255
          AP2   2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                  +y+GVr ++ +g+++AeIrdp+ +g  +r++lg+f ta eAa+a+++ + +l+g
  AT4G17490.1 136 HYRGVRMRP-WGKFAAEIRDPTRRG--TRVWLGTFETAIEAARAYDKEAFRLRG 186
                  7********.**********97665..*************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.730.101.5E-31135195IPR001471AP2/ERF domain
PROSITE profilePS5103223.406136194IPR001471AP2/ERF domain
SuperFamilySSF541715.95E-22136196IPR016177DNA-binding domain
PfamPF008472.3E-11136186IPR001471AP2/ERF domain
CDDcd000183.42E-29136194No hitNo description
SMARTSM003801.1E-34136200IPR001471AP2/ERF domain
PRINTSPR003672.2E-10137148IPR001471AP2/ERF domain
PRINTSPR003672.2E-10160176IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000302Biological Processresponse to reactive oxygen species
GO:0001944Biological Processvasculature development
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0006952Biological Processdefense response
GO:0009644Biological Processresponse to high light intensity
GO:0009873Biological Processethylene-activated signaling pathway
GO:0010200Biological Processresponse to chitin
GO:0051301Biological Processcell division
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 282 aa     Download sequence    Send to blast
MATPNEVSAL FLIKKYLLDE LSPLPTTATT NRWMNDFTSF DQTGFEFSEF ETKPEIIDLV  60
TPKPEIFDFD VKSEIPSESN DSFTFQSNPP RVTVQSNRKP PLKIAPPNRT KWIQFATGNP  120
KPELPVPVVA AEEKRHYRGV RMRPWGKFAA EIRDPTRRGT RVWLGTFETA IEAARAYDKE  180
AFRLRGSKAI LNFPLEVDKW NPRAEDGRGL YNKRKRDGEE EEVTVVEKVL KTEESYDVSG  240
GENVESGLTA IDDWDLTEFL SMPLLSPLSP HPPFGYPQLT VV
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2gcc_A5e-29135198467ATERF1
3gcc_A5e-29135198467ATERF1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.244070.0root| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306840620.0
Genevisible245250_at0.0
Expression AtlasAT4G17490-
AtGenExpressAT4G17490-
ATTED-IIAT4G17490-
Functional Description ? help Back to Top
Source Description
TAIREncodes a member of the ERF (ethylene response factor) subfamily B-3 of ERF/AP2 transcription factor family (ATERF-6). The protein contains one AP2 domain. There are 18 members in this subfamily including ATERF-1, ATERF-2, AND ATERF-5.
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250, ECO:0000269|PubMed:9756931}.
Function -- GeneRIF ? help Back to Top
  1. Reduced inducibilty in ERF6 constitutive overexepressors was consistent with suppression of SA-mediated signalling, as was an increased susceptibility to avirulent Pseudomonas syringae.
    [PMID: 22563431]
  2. These data might provide new insight into the mechanisms that regulate reactive oxygen species-responsive gene transcription via a complex of MPK6, ERF6, and the ROSE7/GCC box under oxidative stress.
    [PMID: 23300166]
  3. ERF6, a substrate of MPK3 and MPK6, plays important roles downstream of the MPK3/MPK6 cascade in regulating plant defense against fungal pathogens.
    [PMID: 23524660]
  4. ERF5 and ERF6 form a missing link between the previously observed stress-induced 1-aminocyclopropane-1-carboxylic acid accumulation and DELLA-mediated cell cycle exit and execute a dual role by regulating both stress tolerance and growth inhibition.
    [PMID: 23553636]
  5. Results indicate that ERF6 plays an important role as a positive antioxidant regulator during plant growth and in response to biotic and abiotic stresses.
    [PMID: 23940555]
  6. Our data demonstrate that dynamic mechanisms exist to fine-tune the stress response and that ERF11 counteracts ERF6 to maintain a balance between plant growth and stress defense.
    [PMID: 25995327]
  7. Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
    [PMID: 27081184]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00437DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT4G17490.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT1G32640 (R)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDethylene
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G17490
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAL1615460.0AL161546.2 Arabidopsis thaliana DNA chromosome 4, contig fragment No. 46.
GenBankCP0026870.0CP002687.1 Arabidopsis thaliana chromosome 4 sequence.
GenBankZ973430.0Z97343.1 Arabidopsis thaliana DNA chromosome 4, ESSA I FCA contig fragment No. 8.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_567529.10.0ethylene responsive element binding factor 6
SwissprotQ8VZ910.0EF103_ARATH; Ethylene-responsive transcription factor 6
TrEMBLA0A178UUL90.0A0A178UUL9_ARATH; ERF6
STRINGAT4G17490.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM10281650
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Durrant WE,Rowland O,Piedras P,Hammond-Kosack KE,Jones JD
    cDNA-AFLP reveals a striking overlap in race-specific resistance and wound response gene expression profiles.
    Plant Cell, 2000. 12(6): p. 963-77
    [PMID:10852940]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. Menges M,Hennig L,Gruissem W,Murray JA
    Cell cycle-regulated gene expression in Arabidopsis.
    J. Biol. Chem., 2002. 277(44): p. 41987-2002
    [PMID:12169696]
  4. Forsbach A,Schubert D,Lechtenberg B,Gils M,Schmidt R
    A comprehensive characterization of single-copy T-DNA insertions in the Arabidopsis thaliana genome.
    Plant Mol. Biol., 2003. 52(1): p. 161-76
    [PMID:12825697]
  5. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  6. Goda H, et al.
    Comprehensive comparison of auxin-regulated and brassinosteroid-regulated genes in Arabidopsis.
    Plant Physiol., 2004. 134(4): p. 1555-73
    [PMID:15047898]
  7. Navarro L, et al.
    The transcriptional innate immune response to flg22. Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis.
    Plant Physiol., 2004. 135(2): p. 1113-28
    [PMID:15181213]
  8. Teige M, et al.
    The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis.
    Mol. Cell, 2004. 15(1): p. 141-52
    [PMID:15225555]
  9. Guan Y,Nothnagel EA
    Binding of arabinogalactan proteins by Yariv phenylglycoside triggers wound-like responses in Arabidopsis cell cultures.
    Plant Physiol., 2004. 135(3): p. 1346-66
    [PMID:15235117]
  10. Scheible WR, et al.
    Genome-wide reprogramming of primary and secondary metabolism, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen.
    Plant Physiol., 2004. 136(1): p. 2483-99
    [PMID:15375205]
  11. Chang S,Pikaard CS
    Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation.
    J. Biol. Chem., 2005. 280(1): p. 796-804
    [PMID:15516340]
  12. Danon A,Miersch O,Felix G,Camp RG,Apel K
    Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana.
    Plant J., 2005. 41(1): p. 68-80
    [PMID:15610350]
  13. Stanley Kim H, et al.
    Transcriptional divergence of the duplicated oxidative stress-responsive genes in the Arabidopsis genome.
    Plant J., 2005. 41(2): p. 212-20
    [PMID:15634198]
  14. Cominelli E, et al.
    A guard-cell-specific MYB transcription factor regulates stomatal movements and plant drought tolerance.
    Curr. Biol., 2005. 15(13): p. 1196-200
    [PMID:16005291]
  15. Lee BH,Henderson DA,Zhu JK
    The Arabidopsis cold-responsive transcriptome and its regulation by ICE1.
    Plant Cell, 2005. 17(11): p. 3155-75
    [PMID:16214899]
  16. Suzuki N, et al.
    Enhanced tolerance to environmental stress in transgenic plants expressing the transcriptional coactivator multiprotein bridging factor 1c.
    Plant Physiol., 2005. 139(3): p. 1313-22
    [PMID:16244138]
  17. Raghavan C,Ong EK,Dalling MJ,Stevenson TW
    Regulation of genes associated with auxin, ethylene and ABA pathways by 2,4-dichlorophenoxyacetic acid in Arabidopsis.
    Funct. Integr. Genomics, 2006. 6(1): p. 60-70
    [PMID:16317577]
  18. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
    [PMID:16407444]
  19. Laskowski M,Biller S,Stanley K,Kajstura T,Prusty R
    Expression profiling of auxin-treated Arabidopsis roots: toward a molecular analysis of lateral root emergence.
    Plant Cell Physiol., 2006. 47(6): p. 788-92
    [PMID:16621846]
  20. Town CD, et al.
    Comparative genomics of Brassica oleracea and Arabidopsis thaliana reveal gene loss, fragmentation, and dispersal after polyploidy.
    Plant Cell, 2006. 18(6): p. 1348-59
    [PMID:16632643]
  21. AbuQamar S, et al.
    Expression profiling and mutant analysis reveals complex regulatory networks involved in Arabidopsis response to Botrytis infection.
    Plant J., 2006. 48(1): p. 28-44
    [PMID:16925600]
  22. Jung J, et al.
    The barley ERF-type transcription factor HvRAF confers enhanced pathogen resistance and salt tolerance in Arabidopsis.
    Planta, 2007. 225(3): p. 575-88
    [PMID:16937017]
  23. Xin Z,Mandaokar A,Chen J,Last RL,Browse J
    Arabidopsis ESK1 encodes a novel regulator of freezing tolerance.
    Plant J., 2007. 49(5): p. 786-99
    [PMID:17316173]
  24. Ma S,Bohnert HJ
    Integration of Arabidopsis thaliana stress-related transcript profiles, promoter structures, and cell-specific expression.
    Genome Biol., 2007. 8(4): p. R49
    [PMID:17408486]
  25. Dombrecht B, et al.
    MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis.
    Plant Cell, 2007. 19(7): p. 2225-45
    [PMID:17616737]
  26. Libault M,Wan J,Czechowski T,Udvardi M,Stacey G
    Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor.
    Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11
    [PMID:17722694]
  27. Ferreira FJ,Guo C,Coleman JR
    Reduction of plastid-localized carbonic anhydrase activity results in reduced Arabidopsis seedling survivorship.
    Plant Physiol., 2008. 147(2): p. 585-94
    [PMID:18434607]
  28. Hu J, et al.
    Transcriptional responses of Arabidopsis thaliana during wilt disease caused by the soil-borne phytopathogenic bacterium, Ralstonia solanacearum.
    PLoS ONE, 2008. 3(7): p. e2589
    [PMID:18596930]
  29. Xu J, et al.
    Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis.
    J. Biol. Chem., 2008. 283(40): p. 26996-7006
    [PMID:18693252]
  30. Son GH, et al.
    Ethylene-responsive element-binding factor 5, ERF5, is involved in chitin-induced innate immunity response.
    Mol. Plant Microbe Interact., 2012. 25(1): p. 48-60
    [PMID:21936663]
  31. Moffat CS, et al.
    ERF5 and ERF6 play redundant roles as positive regulators of JA/Et-mediated defense against Botrytis cinerea in Arabidopsis.
    PLoS ONE, 2012. 7(4): p. e35995
    [PMID:22563431]
  32. Etchells JP,Provost CM,Turner SR
    Plant vascular cell division is maintained by an interaction between PXY and ethylene signalling.
    PLoS Genet., 2012. 8(11): p. e1002997
    [PMID:23166504]
  33. Wang P,Du Y,Zhao X,Miao Y,Song CP
    The MPK6-ERF6-ROS-responsive cis-acting Element7/GCC box complex modulates oxidative gene transcription and the oxidative response in Arabidopsis.
    Plant Physiol., 2013. 161(3): p. 1392-408
    [PMID:23300166]
  34. Meng X, et al.
    Phosphorylation of an ERF transcription factor by Arabidopsis MPK3/MPK6 regulates plant defense gene induction and fungal resistance.
    Plant Cell, 2013. 25(3): p. 1126-42
    [PMID:23524660]
  35. Dubois M, et al.
    Ethylene Response Factor6 acts as a central regulator of leaf growth under water-limiting conditions in Arabidopsis.
    Plant Physiol., 2013. 162(1): p. 319-32
    [PMID:23553636]
  36. Sewelam N, et al.
    Ethylene response factor 6 is a regulator of reactive oxygen species signaling in Arabidopsis.
    PLoS ONE, 2013. 8(8): p. e70289
    [PMID:23940555]
  37. Dubois M, et al.
    The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 Antagonistically Regulate Mannitol-Induced Growth Inhibition in Arabidopsis.
    Plant Physiol., 2015. 169(1): p. 166-79
    [PMID:25995327]
  38. Xu J, et al.
    Pathogen-Responsive MPK3 and MPK6 Reprogram the Biosynthesis of Indole Glucosinolates and Their Derivatives in Arabidopsis Immunity.
    Plant Cell, 2016. 28(5): p. 1144-62
    [PMID:27081184]
  39. Riechmann JL,Meyerowitz EM
    The AP2/EREBP family of plant transcription factors.
    Biol. Chem., 1998. 379(6): p. 633-46
    [PMID:9687012]
  40. Hao D,Ohme-Takagi M,Sarai A
    Unique mode of GCC box recognition by the DNA-binding domain of ethylene-responsive element-binding factor (ERF domain) in plant.
    J. Biol. Chem., 1998. 273(41): p. 26857-61
    [PMID:9756931]