PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G14410.1
Common NamebHLH104, dl3245w, EN136, FCAALL.201
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 283aa    MW: 31995.5 Da    PI: 4.3576
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G14410.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH30.85.4e-10134181454
                  HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                  ++  rEr RR+++N++f  L ++l +    + +K +K +iL  A++ +++L
  AT4G14410.1 134 TKACRERLRREKLNERFMDLSSVLEPG---RTPKTDKPAILDDAIRILNQL 181
                  5678**********************8...8****************9998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088812.671130181IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.7E-7134181IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000838.24E-8134184No hitNo description
SMARTSM003531.5E-8136187IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474595.37E-12136204IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.4E-10137203IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025195anatomypollen tube cell
PO:0025281anatomypollen
PO:0001016developmental stageL mature pollen stage
PO:0001017developmental stageM germinated pollen stage
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 283 aa     Download sequence    Send to blast
MYPSLDDDFV SDLFCFDQSN GAELDDYTQF GVNLQTDQED TFPDFVSYGV NLQQEPDEVF  60
SIGASQLDLS SYNGVLSLEP EQVGQQDCEV VQEEEVEINS GSSGGAVKEE QEHLDDDCSR  120
KRARTGSCSR GGGTKACRER LRREKLNERF MDLSSVLEPG RTPKTDKPAI LDDAIRILNQ  180
LRDEALKLEE TNQKLLEEIK SLKAEKNELR EEKLVLKADK EKTEQQLKSM TAPSSGFIPH  240
IPAAFNHNKM AVYPSYGYMP MWHYMPQSVR DTSRDQELRP PAA
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.42720.0flower| root| silique
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453402170.0
Genevisible245331_at0.0
Expression AtlasAT4G14410-
AtGenExpressAT4G14410-
ATTED-IIAT4G14410-
Function -- GeneRIF ? help Back to Top
  1. bHLH104 and ILR3 play pivotal roles in the regulation of Fe deficiency responses.
    [PMID: 25794933]
  2. bHLH34, bHLH104, and bHLH105 (IAA-LEUCINE RESISTANT3) function as homodimers or heterodimers to nonredundantly regulate Fe homeostasis.
    [PMID: 26921305]
  3. Fe-deficiency-induced expression enhances Fe-deficiency tolerance
    [PMID: 28451750]
  4. functions as a transcriptional repressor for glucose and abscisic acid signaling
    [PMID: 30639920]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00102PBM26531826Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT4G14410.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G14410
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0880530.0AY088053.1 Arabidopsis thaliana clone 40736 mRNA, complete sequence.
GenBankAY1021060.0AY102106.1 Arabidopsis thaliana AT4g14410/dl3245w mRNA, complete cds.
GenBankAY1335650.0AY133565.1 Arabidopsis thaliana At4g14410/dl3245w mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_567431.10.0basic helix-loop-helix (bHLH) DNA-binding superfamily protein
SwissprotQ8L4670.0BH104_ARATH; Transcription factor bHLH104
TrEMBLA0A178UVU10.0A0A178UVU1_ARATH; BHLH104
STRINGAT4G14410.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM40262653
Representative plantOGRP7551766
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  3. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  4. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  5. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  6. Contento AL,Kim SJ,Bassham DC
    Transcriptome profiling of the response of Arabidopsis suspension culture cells to Suc starvation.
    Plant Physiol., 2004. 135(4): p. 2330-47
    [PMID:15310832]
  7. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  8. Wang Y, et al.
    Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
    Plant Physiol., 2008. 148(3): p. 1201-11
    [PMID:18775970]
  9. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  10. Long TA, et al.
    The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.
    Plant Cell, 2010. 22(7): p. 2219-36
    [PMID:20675571]
  11. Selote D,Samira R,Matthiadis A,Gillikin JW,Long TA
    Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors.
    Plant Physiol., 2015. 167(1): p. 273-86
    [PMID:25452667]
  12. Zhang J, et al.
    The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis.
    Plant Cell, 2015. 27(3): p. 787-805
    [PMID:25794933]
  13. Li X,Zhang H,Ai Q,Liang G,Yu D
    Two bHLH Transcription Factors, bHLH34 and bHLH104, Regulate Iron Homeostasis in Arabidopsis thaliana.
    Plant Physiol., 2016. 170(4): p. 2478-93
    [PMID:26921305]
  14. Liang G,Zhang H,Li X,Ai Q,Yu D
    bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana.
    J. Exp. Bot., 2017. 68(7): p. 1743-1755
    [PMID:28369511]
  15. Wang C,Yao X,Yu D,Liang G
    Fe-deficiency-induced expression of bHLH104 enhances Fe-deficiency tolerance of Arabidopsis thaliana.
    Planta, 2017. 246(3): p. 421-431
    [PMID:28451750]
  16. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  17. Min JH, et al.
    Arabidopsis Basic Helix-Loop-Helix 34 (bHLH34) Is Involved in Glucose Signaling through Binding to a GAGA Cis-Element.
    Front Plant Sci, 2017. 8: p. 2100
    [PMID:29321786]
  18. Min JH, et al.
    A basic helix-loop-helix 104 (bHLH104) protein functions as a transcriptional repressor for glucose and abscisic acid signaling in Arabidopsis.
    Plant Physiol. Biochem., 2019. 136: p. 34-42
    [PMID:30639920]