PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G11660.1
Common NameAT-HSFB2B, HSF11, HSF7, HSFB2B, T5C23.90
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family HSF
Protein Properties Length: 377aa    MW: 39705.1 Da    PI: 4.6287
Description HSF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G11660.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind115.53.3e-36601522103
                   HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXXX CS
  HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkellekik 98 
                   Fl+k+y+++ed+ ++elisw+e+g++f+v+ + efa+++LpkyFkh+nf+SFvRQLn+YgF+kv  ++         weF+++ Fk+g+k ll++i+
   AT4G11660.1  60 FLTKTYQLVEDPVYDELISWNEDGTTFIVWRPAEFARDLLPKYFKHNNFSSFVRQLNTYGFRKVVPDR---------WEFSNDCFKRGEKILLRDIQ 147
                   9*****************************************************************99.........******************** PP

                   XXXXX CS
  HSF_DNA-bind  99 rkkse 103
                   r+k +
   AT4G11660.1 148 RRKIS 152
                   **865 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM004151.6E-5856149IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene3DG3DSA:1.10.10.109.4E-3857149IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.27E-3457149IPR011991Winged helix-turn-helix DNA-binding domain
PRINTSPR000563.5E-206083IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004477.7E-3260149IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000563.5E-2098110IPR000232Heat shock factor (HSF)-type, DNA-binding
PROSITE patternPS00434099123IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000563.5E-20111123IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene3DG3DSA:1.20.5.1708.1E-4228255No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010200Biological Processresponse to chitin
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001017developmental stageM germinated pollen stage
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 377 aa     Download sequence    Send to blast
MPGEQTGETP TVAGVGGGGA GCSAGNSGGS SGCGAGGGGG GSGGGGGGGG DSQRSIPTPF  60
LTKTYQLVED PVYDELISWN EDGTTFIVWR PAEFARDLLP KYFKHNNFSS FVRQLNTYGF  120
RKVVPDRWEF SNDCFKRGEK ILLRDIQRRK ISQPAMAAAA AAAAAAVAAS AVTVAAVPVV  180
AHIVSPSNSG EEQVISSNSS PAAAAAAIGG VVGGGSLQRT TSCTTAPELV EENERLRKDN  240
ERLRKEMTKL KGLYANIYTL MANFTPGQED CAHLLPEGKP LDLLPERQEM SEAIMASEIE  300
TGIGLKLGED LTPRLFGVSI GVKRARREEE LGAAEEEDDD RREAAAQEGE QSSDVKAEPM  360
EENNSGNHNG SWLELGK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5d5u_B1e-27291491129Heat shock factor protein 1
5d5v_B1e-27291491129Heat shock factor protein 1
5d5v_D1e-27291491129Heat shock factor protein 1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.249950.0root| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453401150.0
Genevisible254878_at0.0
Expression AtlasAT4G11660-
AtGenExpressAT4G11660-
ATTED-IIAT4G11660-
Functional Description ? help Back to Top
Source Description
TAIRmember of Heat Stress Transcription Factor (Hsf) family
UniProtTranscriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Function -- GeneRIF ? help Back to Top
  1. Data suggest that HsfB1 and HsfB2b may be involved in complex regulatory networks, which are linked to other stress responses and signaling processes.
    [PMID: 19945192]
  2. These data indicate that HsfB1 and HsfB2b suppress the general heat shock response under non-heat-stress conditions and in the attenuating period.
    [PMID: 21908690]
  3. The constitutive expression of HsfB2b leads to severely reduced levels of the PRR7 transcript and late flowering and elongated hypocotyls.
    [PMID: 25352668]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00432DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT4G11660.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Interaction ? help Back to Top
Source Intact With
BioGRIDAT4G11660
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G11660
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0084710.0BT008471.1 Arabidopsis thaliana At4g11660 gene, complete cds.
GenBankAY0932060.0AY093206.1 Arabidopsis thaliana heat shock transcription factor-like protein (At4g11660) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_192903.10.0heat stress transcription factor B-2b
SwissprotQ9T0D30.0HFB2B_ARATH; Heat stress transcription factor B-2b
TrEMBLD7LZP10.0D7LZP1_ARALL; Putative uncharacterized protein
STRINGAT4G11660.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP9617233
MalvidsOGEM96528111
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Nover L, et al.
    Arabidopsis and the heat stress transcription factor world: how many heat stress transcription factors do we need?
    Cell Stress Chaperones, 2001. 6(3): p. 177-89
    [PMID:11599559]
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  4. Lohmann C,Eggers-Schumacher G,Wunderlich M,Sch
    Two different heat shock transcription factors regulate immediate early expression of stress genes in Arabidopsis.
    Mol. Genet. Genomics, 2004. 271(1): p. 11-21
    [PMID:14655047]
  5. Vanderauwera S, et al.
    Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis.
    Plant Physiol., 2005. 139(2): p. 806-21
    [PMID:16183842]
  6. Charng YY, et al.
    A heat-inducible transcription factor, HsfA2, is required for extension of acquired thermotolerance in Arabidopsis.
    Plant Physiol., 2007. 143(1): p. 251-62
    [PMID:17085506]
  7. Libault M,Wan J,Czechowski T,Udvardi M,Stacey G
    Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor.
    Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11
    [PMID:17722694]
  8. Guo J, et al.
    Genome-wide analysis of heat shock transcription factor families in rice and Arabidopsis.
    J Genet Genomics, 2008. 35(2): p. 105-18
    [PMID:18407058]
  9. Krishnaswamy SS, et al.
    Transcriptional profiling of pea ABR17 mediated changes in gene expression in Arabidopsis thaliana.
    BMC Plant Biol., 2008. 8: p. 91
    [PMID:18783601]
  10. Ikeda M,Ohme-Takagi M
    A novel group of transcriptional repressors in Arabidopsis.
    Plant Cell Physiol., 2009. 50(5): p. 970-5
    [PMID:19324928]
  11. Kumar M, et al.
    Heat shock factors HsfB1 and HsfB2b are involved in the regulation of Pdf1.2 expression and pathogen resistance in Arabidopsis.
    Mol Plant, 2009. 2(1): p. 152-65
    [PMID:19529832]
  12. Li M, et al.
    Detection of in vivo interactions between Arabidopsis class A-HSFs, using a novel BiFC fragment, and identification of novel class B-HSF interacting proteins.
    Eur. J. Cell Biol., 2010 Feb-Mar. 89(2-3): p. 126-32
    [PMID:19945192]
  13. Ikeda M,Mitsuda N,Ohme-Takagi M
    Arabidopsis HsfB1 and HsfB2b act as repressors of the expression of heat-inducible Hsfs but positively regulate the acquired thermotolerance.
    Plant Physiol., 2011. 157(3): p. 1243-54
    [PMID:21908690]
  14. Causier B,Ashworth M,Guo W,Davies B
    The TOPLESS interactome: a framework for gene repression in Arabidopsis.
    Plant Physiol., 2012. 158(1): p. 423-38
    [PMID:22065421]
  15. Zhu X,Thalor SK,Takahashi Y,Berberich T,Kusano T
    An inhibitory effect of the sequence-conserved upstream open-reading frame on the translation of the main open-reading frame of HsfB1 transcripts in Arabidopsis.
    Plant Cell Environ., 2012. 35(11): p. 2014-30
    [PMID:22571635]
  16. Kolmos E,Chow BY,Pruneda-Paz JL,Kay SA
    HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock.
    Proc. Natl. Acad. Sci. U.S.A., 2014. 111(45): p. 16172-7
    [PMID:25352668]