PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G02590.2
Common NameBHLH59, EN93, T10P11.13, UNE12
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 310aa    MW: 33105.4 Da    PI: 6.313
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G02590.2genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH27.17.7e-09157201554
                  HHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHH CS
          HLH   5 hnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksL 54 
                  h+++Er RR+ri +++  L+el+P+ +      K + a++  + v+Y+k L
  AT4G02590.2 157 HSIAERLRRERIAERIRALQELVPTvN------KTDRAAMIDEIVDYVKFL 201
                  99***********************55......9**************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474591.44E-14150211IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.802152201IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.104.6E-14154211IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.9E-6157201IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003537.0E-10158207IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0007275Biological Processmulticellular organism development
GO:0009567Biological Processdouble fertilization forming a zygote and endosperm
GO:0031347Biological Processregulation of defense response
GO:0045944Biological Processpositive regulation of transcription from RNA polymerase II promoter
GO:0005634Cellular Componentnucleus
GO:0001046Molecular Functioncore promoter sequence-specific DNA binding
GO:0001228Molecular Functiontranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 310 aa     Download sequence    Send to blast
MASNNPHDNL SDQTPSDDFF EQILGLPNFS ASSAAGLSGV DGGLGGGAPP MMLQLGSGEE  60
GSHMGGLGGS GPTGFHNQMF PLGLSLDQGK GPGFLRPEGG HGSGKRFSDD VVDNRCSSMK  120
PVFHGQPMQQ PPPSAPHQPT SIRPRVRARR GQATDPHSIA ERLRRERIAE RIRALQELVP  180
TVNKTDRAAM IDEIVDYVKF LRLQVKVLSM SRLGGAGAVA PLVTDMPLSS SVEDETGEGG  240
RTPQPAWEKW SNDGTERQVA KLMEENVGAA MQLLQSKALC MMPISLAMAI YHSQPPDTSS  300
VVKPENNPPQ
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1161166RLRRER
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.200280.0bud| flower| leaf| root| seed| vegetative tissue
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306792040.0
Genevisible255497_at0.0
Expression AtlasAT4G02590-
AtGenExpressAT4G02590-
ATTED-IIAT4G02590-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems, and flowers. {ECO:0000269|PubMed:12679534}.
Functional Description ? help Back to Top
Source Description
UniProtRequired for ovule fertilization. {ECO:0000269|PubMed:15634699}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT4G02590.2
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G03040, AT1G31050, AT1G62990, AT1G77950
IntActSearch O22768
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G02590
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF3673280.0AF367328.1 Arabidopsis thaliana AT4g02590/T10P11_13 mRNA, complete cds.
GenBankAK3167480.0AK316748.1 Arabidopsis thaliana AT4G02590 mRNA, complete cds, clone: RAFL07-83-K16.
GenBankAY1439510.0AY143951.1 Arabidopsis thaliana At4g02590/T10P11_13 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001031577.10.0basic helix-loop-helix (bHLH) DNA-binding superfamily protein
RefseqNP_567245.10.0basic helix-loop-helix (bHLH) DNA-binding superfamily protein
SwissprotO227680.0UNE12_ARATH; Transcription factor UNE12
TrEMBLA0A384KS030.0A0A384KS03_ARATH; UNE12
TrEMBLB9DFF40.0B9DFF4_ARATH; AT4G02590 protein
STRINGAT4G02590.10.0(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  3. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  4. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  5. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  6. Pagnussat GC, et al.
    Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis.
    Development, 2005. 132(3): p. 603-14
    [PMID:15634699]
  7. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  8. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  9. Brady SM, et al.
    A stele-enriched gene regulatory network in the Arabidopsis root.
    Mol. Syst. Biol., 2011. 7: p. 459
    [PMID:21245844]
  10. Mukhtar MS, et al.
    Independently evolved virulence effectors converge onto hubs in a plant immune system network.
    Science, 2011. 333(6042): p. 596-601
    [PMID:21798943]
  11. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  12. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  13. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  14. We
    Convergent targeting of a common host protein-network by pathogen effectors from three kingdoms of life.
    Cell Host Microbe, 2014. 16(3): p. 364-75
    [PMID:25211078]