PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT3G57670.1
Common NameF15B8.140, NTT, WIP2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 383aa    MW: 43337.1 Da    PI: 6.8718
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT3G57670.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H2163.4e-05217236120
                  EEETTTTEEESSHHHHHHHH CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHi 20 
                  ++Cp C k+F+r  n++ H+
  AT3G57670.1 217 FSCPVCFKTFNRYNNMQMHM 236
                  89*****************9 PP

2zf-C2H214.40.00011301323123
                  EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                  + C +Cgk F  + + ++H +++
  AT3G57670.1 301 FMCRKCGKAFAVRGDWRTHEKNC 323
                  89*****************9987 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM003550.38217239IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.64217244IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.605.6E-6217236IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS000280219239IPR007087Zinc finger, C2H2
SuperFamilySSF576671.88E-6283321No hitNo description
Gene3DG3DSA:3.30.160.601.1E-5297321IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS501578.808301321IPR007087Zinc finger, C2H2
SMARTSM0035549301321IPR015880Zinc finger, C2H2-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009860Biological Processpollen tube growth
GO:0010500Biological Processtransmitting tissue development
GO:1990058Biological Processfruit replum development
GO:0005634Cellular Componentnucleus
GO:0003676Molecular Functionnucleic acid binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000293anatomyguard cell
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009052anatomyflower pedicel
PO:0020003anatomyplant ovule
PO:0020006anatomyfunicle
PO:0020102anatomyportion of transmitting tissue
PO:0025022anatomycollective leaf structure
PO:0025268anatomyfruit septum
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001185developmental stageplant embryo globular stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 383 aa     Download sequence    Send to blast
MTDPYSNFFT DWFKSNPFHH YPNSSTNPSP HPLPPVTPPS SFFFFPQSGD LRRPPPPPTP  60
PPSPPLREAL PLLSLSPANK QQDHHHNHDH LIQEPPSTSM DVDYDHHHQD DHHNLDDDDH  120
DVTVALHIGL PSPSAQEMAS LLMMSSSSSS SRTTHHHEDM NHKKDLDHEY SHGAVGGGED  180
DDEDSVGGDG GCRISRLNKG QYWIPTPSQI LIGPTQFSCP VCFKTFNRYN NMQMHMWGHG  240
SQYRKGPESL RGTQPTGMLR LPCYCCAPGC RNNIDHPRAK PLKDFRTLQT HYKRKHGIKP  300
FMCRKCGKAF AVRGDWRTHE KNCGKLWYCI CGSDFKHKRS LKDHIKAFGN GHGAYGIDGF  360
DEEDEPASEV EQLDNDHESM QSK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.283100.0bud
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306946960.0
Genevisible251592_at0.0
Expression AtlasAT3G57670-
AtGenExpressAT3G57670-
ATTED-IIAT3G57670-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in developing carpels (PubMed:17600712). Expressed in the shoot apical meristem and the replum (PubMed:25039392). {ECO:0000269|PubMed:17600712}.
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional regulator required for normal differentiation of the ovary transmitting tract cells and pollen tube growth. In Arabidopsis, the transmitting tract facilitates the transport of pollen tubes to the ovules for fertilization (PubMed:17600712). May play a role in the regulation of AGL8/FUL, which is required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique (PubMed:23515580). Plays a role in replum development by the activation of the homeobox protein KNAT1 (PubMed:25039392). {ECO:0000269|PubMed:17600712, ECO:0000269|PubMed:23515580, ECO:0000269|PubMed:25039392}.
Function -- GeneRIF ? help Back to Top
  1. Required for transmitting-tract development; mutations cause reduced fertility by severely inhibiting pollen-tube movement
    [PMID: 17600712]
  2. These results indicate that NTT suppresses FUL, indicating a potential role in patterning of the silique.
    [PMID: 23515580]
  3. NTT loss of function leads to reduced replum width and cell number, whereas increased expression promotes replum enlargement. NTT activates the homeobox gene BP, which, together with RPL, is important for replum development.
    [PMID: 25039392]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT3G57670.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Interaction ? help Back to Top
Source Intact With
IntActSearch Q9SVY1
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Reduced fertility, fruit length and seed set (PubMed:17600712). Reduced replum width and cell number (PubMed:25039392). {ECO:0000269|PubMed:17600712, ECO:0000269|PubMed:25039392}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT3G57670
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF2544470.0AF254447.1 Arabidopsis thaliana WIP2 protein (WIP2) mRNA, complete cds.
GenBankBT0210890.0BT021089.1 Arabidopsis thaliana At3g57670 gene, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_191326.10.0transcription factor NO TRANSMITTING TRACT
SwissprotQ9SVY10.0ZWIP2_ARATH; Zinc finger protein WIP2
TrEMBLD7LVV40.0D7LVV4_ARALL; Putative uncharacterized protein
STRINGAT3G57670.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP4101597
MalvidsOGEM23928237
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Sagasser M,Lu GH,Hahlbrock K,Weisshaar B
    A. thaliana TRANSPARENT TESTA 1 is involved in seed coat development and defines the WIP subfamily of plant zinc finger proteins.
    Genes Dev., 2002. 16(1): p. 138-49
    [PMID:11782451]
  3. Dal Bosco C, et al.
    Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.
    J. Biol. Chem., 2004. 279(2): p. 1060-9
    [PMID:14576160]
  4. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  5. Englbrecht CC,Schoof H,B
    Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.
    BMC Genomics, 2004. 5(1): p. 39
    [PMID:15236668]
  6. Crawford BC,Ditta G,Yanofsky MF
    The NTT gene is required for transmitting-tract development in carpels of Arabidopsis thaliana.
    Curr. Biol., 2007. 17(13): p. 1101-8
    [PMID:17600712]
  7. Dortay H, et al.
    Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana.
    J. Proteome Res., 2008. 7(9): p. 3649-60
    [PMID:18642946]
  8. Appelhagen I, et al.
    Weird fingers: functional analysis of WIP domain proteins.
    FEBS Lett., 2010. 584(14): p. 3116-22
    [PMID:20541552]
  9. Crawford BC,Yanofsky MF
    HALF FILLED promotes reproductive tract development and fertilization efficiency in Arabidopsis thaliana.
    Development, 2011. 138(14): p. 2999-3009
    [PMID:21693516]
  10. Chung KS,Lee JH,Lee JS,Ahn JH
    Fruit indehiscence caused by enhanced expression of NO TRANSMITTING TRACT in Arabidopsis thaliana.
    Mol. Cells, 2013. 35(6): p. 519-25
    [PMID:23515580]
  11. Marsch-Mart
    The NTT transcription factor promotes replum development in Arabidopsis fruits.
    Plant J., 2014. 80(1): p. 69-81
    [PMID:25039392]
  12. Zhou X,Groves NR,Meier I
    Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.
    Nucleus, 2015. 6(2): p. 144-53
    [PMID:25759303]