PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT3G49850.1
Common NameATTRB3, T16K5.200, TBP2, TRB3
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family MYB_related
Protein Properties Length: 295aa    MW: 32247 Da    PI: 10.1594
Description telomere repeat binding factor 3
Gene Model
Gene Model ID Type Source Coding Sequence
AT3G49850.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding39.31.5e-12555146
                     TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHT.....TTS-HHHHHHHHHH CS
  Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmg.....kgRtlkqcksrwqk 46
                     +++WT+eE+  l+ +v ++G+g W+tI +        k R+  ++k++w++
      AT3G49850.1  5 KLKWTPEEETALKAGVLKHGTGKWRTILSDPVystilKSRSNVDLKDKWRN 55
                     689**********************************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5129413.675161IPR017930Myb domain
SuperFamilySSF466894.34E-15259IPR009057Homeodomain-like
SMARTSM007175.3E-6459IPR001005SANT/Myb domain
PfamPF002494.7E-8555IPR001005SANT/Myb domain
Gene3DG3DSA:1.10.10.602.7E-13556IPR009057Homeodomain-like
CDDcd116601.45E-17756No hitNo description
SMARTSM005261.0E-15117182IPR005818Linker histone H1/H5, domain H15
SuperFamilySSF467851.09E-11117197IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.5E-8117188IPR011991Winged helix-turn-helix DNA-binding domain
PROSITE profilePS5150418.529119187IPR005818Linker histone H1/H5, domain H15
PfamPF005384.1E-5121180IPR005818Linker histone H1/H5, domain H15
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006334Biological Processnucleosome assembly
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009651Biological Processresponse to salt stress
GO:0009723Biological Processresponse to ethylene
GO:0009733Biological Processresponse to auxin
GO:0009739Biological Processresponse to gibberellin
GO:0009751Biological Processresponse to salicylic acid
GO:0009753Biological Processresponse to jasmonic acid
GO:0031627Biological Processtelomeric loop formation
GO:0046686Biological Processresponse to cadmium ion
GO:0000784Cellular Componentnuclear chromosome, telomeric region
GO:0000785Cellular Componentchromatin
GO:0000786Cellular Componentnucleosome
GO:0005730Cellular Componentnucleolus
GO:0003691Molecular Functiondouble-stranded telomeric DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0042803Molecular Functionprotein homodimerization activity
GO:0043047Molecular Functionsingle-stranded telomeric DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007131developmental stageseedling development stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 295 aa     Download sequence    Send to blast
MGAPKLKWTP EEETALKAGV LKHGTGKWRT ILSDPVYSTI LKSRSNVDLK DKWRNISVTA  60
LWGSRKKAKL ALKRTPLSGS RQDDNATAIT IVSLANGDVG GQQIDAPSPP AGSCEPPRPS  120
TSVDKIILEA ITSLKRPFGP DGKSILMYIE ENFKMQPDMK RLVTSRLKYL TNVGTLVKKK  180
HKYRISQNYM AEGEGQRSPQ LLLEGNKENT PKPEENGVKN LTKSQVGGEV MIMGMTEKEA  240
AAAAARAVAE AEFAMAEAEE AAREADKAEA EAEAAHIFAK AAMKAVKYRM HSQTR
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.266460.0flower| root
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible252223_at0.0
Expression AtlasAT3G49850-
AtGenExpressAT3G49850-
ATTED-IIAT3G49850-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15060584}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a telomeric DNA binding protein. In vitro, the protein preferentially binds double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
UniProtBinds preferentially double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand. {ECO:0000269|PubMed:19102728}.
Function -- GeneRIF ? help Back to Top
  1. Under endoplasmic reticulum stress, TRB3 was up-regulated, resulting in inhibiting the activation of AKT in oral tongue squamous cell carcinoma.
    [PMID: 21821462]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT3G49850.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDauxin, ethylene, gibberellin, jasmonic acid, salicylic acid
Interaction -- BIND ? help Back to Top
Source Intact With Description
BINDAT1G49950TRB1 interacts with TRB3.
BINDAT5G67580TRB2 interacts with TRB3.
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G67580, AT1G49950
IntActSearch Q9M2X3
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT3G49850
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0588870.0AY058887.1 Arabidopsis thaliana AT3g49850/T16K5_200 mRNA, complete cds.
GenBankAY0650690.0AY065069.1 Arabidopsis thaliana AT3g49850/T16K5_200 mRNA, complete cds.
GenBankAY0790430.0AY079043.1 Arabidopsis thaliana AT3g49850/T16K5_200 mRNA, complete cds.
GenBankAY5195420.0AY519542.1 Arabidopsis thaliana MYB transcription factor (At3g49850) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001326904.10.0telomere repeat binding factor 3
RefseqNP_190554.10.0telomere repeat binding factor 3
SwissprotQ9M2X30.0TRB3_ARATH; Telomere repeat-binding factor 3
TrEMBLA0A178VB210.0A0A178VB21_ARATH; TRB3
STRINGAT3G49850.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM38092759
Representative plantOGRP8551659
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Marian CO, et al.
    The maize Single myb histone 1 gene, Smh1, belongs to a novel gene family and encodes a protein that binds telomere DNA repeats in vitro.
    Plant Physiol., 2003. 133(3): p. 1336-50
    [PMID:14576282]
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  4. Hoth S, et al.
    Monitoring genome-wide changes in gene expression in response to endogenous cytokinin reveals targets in Arabidopsis thaliana.
    FEBS Lett., 2003. 554(3): p. 373-80
    [PMID:14623097]
  5. Schrumpfová P, et al.
    Characterization of two Arabidopsis thaliana myb-like proteins showing affinity to telomeric DNA sequence.
    Genome, 2004. 47(2): p. 316-24
    [PMID:15060584]
  6. Kuchar M,Fajkus J
    Interactions of putative telomere-binding proteins in Arabidopsis thaliana: identification of functional TRF2 homolog in plants.
    FEBS Lett., 2004. 578(3): p. 311-5
    [PMID:15589838]
  7. Yanhui C, et al.
    The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family.
    Plant Mol. Biol., 2006. 60(1): p. 107-24
    [PMID:16463103]
  8. Schrumpfov
    Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana.
    FEBS Lett., 2008. 582(10): p. 1400-6
    [PMID:18387366]
  9. Hofr C, et al.
    Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specificity and kinetics.
    Biochem. J., 2009. 419(1): p. 221-8, 2 p following 228
    [PMID:19102728]
  10. Dvorácková M, et al.
    AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin.
    Plant J., 2010. 61(4): p. 637-49
    [PMID:19947985]
  11. Zhang J, et al.
    TRB3 overexpression due to endoplasmic reticulum stress inhibits AKT kinase activation of tongue squamous cell carcinoma.
    Oral Oncol., 2011. 47(10): p. 934-9
    [PMID:21821462]
  12. Zhou Y,Hartwig B,James GV,Schneeberger K,Turck F
    Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes.
    Plant Cell, 2016. 28(1): p. 87-101
    [PMID:26721861]
  13. Denis E, et al.
    WOX14 promotes bioactive gibberellin synthesis and vascular cell differentiation in Arabidopsis.
    Plant J., 2017. 90(3): p. 560-572
    [PMID:28218997]
  14. Kotliński M, et al.
    Phylogeny-Based Systematization of Arabidopsis Proteins with Histone H1 Globular Domain.
    Plant Physiol., 2017. 174(1): p. 27-34
    [PMID:28298478]