PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT3G12680.1
Common NameHUA1, T2E22.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C3H
Protein Properties Length: 524aa    MW: 57653.6 Da    PI: 7.6243
Description floral homeotic protein (HUA1)
Gene Model
Gene Model ID Type Source Coding Sequence
AT3G12680.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-CCCH345e-11177200326
                  S---SGGGGTS--TTTTT-SS-SS CS
      zf-CCCH   3 telCrffartGtCkyGdrCkFaHg 26 
                  ++ C ++++t tCk+G++C+F H+
  AT3G12680.1 177 EKDCTHYMQTRTCKFGESCRFDHP 200
                  678********************8 PP

2zf-CCCH33.19.8e-11226252127
                  --S---SGGGGTS--TTTTT-SS-SSS CS
      zf-CCCH   1 yktelCrffartGtCkyGdrCkFaHgp 27 
                  ++++ C+++ +t  CkyG++CkF+H++
  AT3G12680.1 226 PGEPDCPYYIKTQRCKYGSKCKFNHPR 252
                  5789*********************96 PP

3zf-CCCH37.44.2e-12271295327
                  S---SGGGGTS--TTTTT-SS-SSS CS
      zf-CCCH   3 telCrffartGtCkyGdrCkFaHgp 27 
                  ++ C f+++tG Ck+G +CkF+H++
  AT3G12680.1 271 EPMCTFYMKTGKCKFGLSCKFHHPK 295
                  689********************96 PP

4zf-CCCH38.22.4e-12342367227
                  -S---SGGGGTS--TTTTT-SS-SSS CS
      zf-CCCH   2 ktelCrffartGtCkyGdrCkFaHgp 27 
                  +++ C+f+++tG CkyG++C+++H++
  AT3G12680.1 342 GEVDCPFYLKTGSCKYGATCRYNHPE 367
                  5789********************96 PP

5zf-CCCH413.3e-13422446226
                  -S---SGGGGTS--TTTTT-SS-SS CS
      zf-CCCH   2 ktelCrffartGtCkyGdrCkFaHg 26 
                  ++++C+++++tG+Ck+G+rCkF+H+
  AT3G12680.1 422 GQSECDYYMKTGECKFGERCKFHHP 446
                  7899********************8 PP

6zf-CCCH41.42.3e-13478500527
                  --SGGGGTS--TTTTT-SS-SSS CS
      zf-CCCH   5 lCrffartGtCkyGdrCkFaHgp 27 
                  +C+++++tGtCkyG++CkF H+p
  AT3G12680.1 478 NCPYYMKTGTCKYGATCKFDHPP 500
                  6********************96 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5010313.281174202IPR000571Zinc finger, CCCH-type
SuperFamilySSF902292.09E-5175201IPR000571Zinc finger, CCCH-type
SMARTSM003560.013176201IPR000571Zinc finger, CCCH-type
PfamPF006422.0E-8177200IPR000571Zinc finger, CCCH-type
Gene3DG3DSA:4.10.1000.102.9E-4180199IPR000571Zinc finger, CCCH-type
SMARTSM003561.2E-4225252IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010315.047225253IPR000571Zinc finger, CCCH-type
PfamPF006422.7E-7227252IPR000571Zinc finger, CCCH-type
SuperFamilySSF902293.4E-6230255IPR000571Zinc finger, CCCH-type
Gene3DG3DSA:4.10.1000.104.1E-6231254IPR000571Zinc finger, CCCH-type
SMARTSM003567.4E-5268295IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010315.657268296IPR000571Zinc finger, CCCH-type
SuperFamilySSF902294.32E-6271296IPR000571Zinc finger, CCCH-type
Gene3DG3DSA:4.10.1000.101.0E-5273294IPR000571Zinc finger, CCCH-type
PfamPF006425.1E-9274295IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010315.197340368IPR000571Zinc finger, CCCH-type
SMARTSM003564.5E-7340367IPR000571Zinc finger, CCCH-type
PfamPF006426.7E-10342367IPR000571Zinc finger, CCCH-type
SuperFamilySSF902292.09E-5344368IPR000571Zinc finger, CCCH-type
Gene3DG3DSA:4.10.1000.101.3E-4346367IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010314.953420448IPR000571Zinc finger, CCCH-type
SMARTSM003565.9E-6420447IPR000571Zinc finger, CCCH-type
SuperFamilySSF902296.93E-7421451IPR000571Zinc finger, CCCH-type
PfamPF006421.2E-10422446IPR000571Zinc finger, CCCH-type
Gene3DG3DSA:4.10.1000.107.1E-6426447IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010314.389473501IPR000571Zinc finger, CCCH-type
SMARTSM003562.8E-6473500IPR000571Zinc finger, CCCH-type
SuperFamilySSF902291.26E-5478500IPR000571Zinc finger, CCCH-type
PfamPF006427.7E-11478500IPR000571Zinc finger, CCCH-type
Gene3DG3DSA:4.10.1000.101.6E-5479498IPR000571Zinc finger, CCCH-type
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0001709Biological Processcell fate determination
GO:0006397Biological ProcessmRNA processing
GO:0009908Biological Processflower development
GO:0061158Biological Process3'-UTR-mediated mRNA destabilization
GO:0005634Cellular Componentnucleus
GO:0005829Cellular Componentcytosol
GO:0016607Cellular Componentnuclear speck
GO:0003677Molecular FunctionDNA binding
GO:0003723Molecular FunctionRNA binding
GO:0003730Molecular FunctionmRNA 3'-UTR binding
GO:0046872Molecular Functionmetal ion binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 524 aa     Download sequence    Send to blast
MAHRQLYSYA LQPSYAAAAS TVSPAPPPPQ QPLPPKTGLS SLYGSSADHY FPDTTYRFLA  60
RDGSEALSNY SGTLASSSSM YHHLPNTTAS HLAYPQLLQH QEVAWPPGVE VPGAASAVEP  120
LPPGVKRTSE ALYYPTLLGA HNTIGQTEAW YTTDYFTKRP KLESTSHLPI YPQRAGEKDC  180
THYMQTRTCK FGESCRFDHP IWVPEGGIPD WKEAPVVPNE EYPERPGEPD CPYYIKTQRC  240
KYGSKCKFNH PREEAAVSVE TQDSLPERPS EPMCTFYMKT GKCKFGLSCK FHHPKDIQLP  300
SSSQDIGSSV GLTSEPDATN NPHVTFTPAL YHNSKGLPVR SGEVDCPFYL KTGSCKYGAT  360
CRYNHPERTA FIPQAAGVNY SLVSSNTANL NLGLVTPATS FYQTLTQPTL GVISATYPQR  420
PGQSECDYYM KTGECKFGER CKFHHPADRL SAMTKQAPQQ PNVKLSLAGY PRREGALNCP  480
YYMKTGTCKY GATCKFDHPP PGEVMAKTTS EADAAGATNT DTTQ
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.56700.0flower| leaf
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453384240.0
Genevisible257695_at0.0
Expression AtlasAT3G12680-
AtGenExpressAT3G12680-
ATTED-IIAT3G12680-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Highly expressed in inflorescences, at intermediate levels in leaves and stems and at lower levels in roots. {ECO:0000269|PubMed:11595801}.
Functional Description ? help Back to Top
Source Description
TAIRMember of the floral homeotic AGAMOUS pathway.
UniProtInvolved in flower development (PubMed:11595801, PubMed:12530963). Functions in floral reproductive organ identity by binding AGAMOUS (AG) pre-mRNA and promoting its processing. Functions in association with HUA2 and HEN4 (PubMed:12530963). {ECO:0000269|PubMed:11595801, ECO:0000269|PubMed:12530963}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT3G12680.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT3G12680
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0243570.0AY024357.1 Arabidopsis thaliana floral homeotic protein HUA1 (HUA1) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_187874.20.0floral homeotic protein HUA1
SwissprotQ941Q30.0C3H37_ARATH; Zinc finger CCCH domain-containing protein 37
TrEMBLD7L0J20.0D7L0J2_ARALL; Enhancer of ag-4 1
STRINGAT3G12680.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP67541519
MalvidsOGEM97612836
Publications ? help Back to Top
  1. Chen X,Meyerowitz EM
    HUA1 and HUA2 are two members of the floral homeotic AGAMOUS pathway.
    Mol. Cell, 1999. 3(3): p. 349-60
    [PMID:10198637]
  2. Li J,Jia D,Chen X
    HUA1, a regulator of stamen and carpel identities in Arabidopsis, codes for a nuclear RNA binding protein.
    Plant Cell, 2001. 13(10): p. 2269-81
    [PMID:11595801]
  3. Chen X,Liu J,Cheng Y,Jia D
    HEN1 functions pleiotropically in Arabidopsis development and acts in C function in the flower.
    Development, 2002. 129(5): p. 1085-94
    [PMID:11874905]
  4. Western TL,Cheng Y,Liu J,Chen X
    HUA ENHANCER2, a putative DExH-box RNA helicase, maintains homeotic B and C gene expression in Arabidopsis.
    Development, 2002. 129(7): p. 1569-81
    [PMID:11923195]
  5. Jack T
    New members of the floral organ identity AGAMOUS pathway.
    Trends Plant Sci., 2002. 7(7): p. 286-7
    [PMID:12119159]
  6. Cheng Y,Kato N,Wang W,Li J,Chen X
    Two RNA binding proteins, HEN4 and HUA1, act in the processing of AGAMOUS pre-mRNA in Arabidopsis thaliana.
    Dev. Cell, 2003. 4(1): p. 53-66
    [PMID:12530963]
  7. Wang D, et al.
    Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.
    BMC Genomics, 2008. 9: p. 44
    [PMID:18221561]
  8. Rodr
    K-homology nuclear ribonucleoproteins regulate floral organ identity and determinacy in arabidopsis.
    PLoS Genet., 2015. 11(2): p. e1004983
    [PMID:25658099]