PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G41940.1
Common NameT6D20.16, ZFP8
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 257aa    MW: 29571.2 Da    PI: 8.3017
Description zinc finger protein 8
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G41940.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H215.45.3e-0595117123
                  EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                  ++C++C + F+++  L  H++ H
  AT2G41940.1  95 FECHYCFRNFPTSQALGGHQNAH 117
                  89******************988 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576671.6E-591123No hitNo description
PfamPF139122.0E-594119IPR007087Zinc finger, C2H2
PROSITE profilePS5015710.9995122IPR007087Zinc finger, C2H2
PROSITE patternPS00028097117IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007275Biological Processmulticellular organism development
GO:0010026Biological Processtrichome differentiation
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 257 aa     Download sequence    Send to blast
MDETNGRRET HDFMNVNVES FSQLPFIRRT PPKEKAAIIR LFGQELVGDN SDNLSAEPSD  60
HQTTTKNDES SENIKDKDKE KDKDKDKDNN NNRRFECHYC FRNFPTSQAL GGHQNAHKRE  120
RQHAKRGSMT SYLHHHQPHD PHHIYGFLNN HHHRHYPSWT TEARSYYGGG GHQTPSYYSR  180
NTLAPPSSNP PTINGSPLGL WRVPPSTSTN TIQGVYSSSP ASAFRSHEQE TNKEPNNWPY  240
RLMKPNVQDH VSLDLHL
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.204020.0flower
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO425698520.0
Genevisible267535_at0.0
Expression AtlasAT2G41940-
AtGenExpressAT2G41940-
ATTED-IIAT2G41940-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in developing cauline leaves. {ECO:0000269|PubMed:17507408}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a zinc finger protein containing only a single zinc finger.
UniProtProbable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin. Is not involved in the regulation of trichome branching. Is functionally equivalent to GIS2 (PubMed:17507408). Acts as negative regulator of abscisic acid (ABA) signaling during germination and early seedling development (PubMed:24808098). {ECO:0000269|PubMed:17507408, ECO:0000269|PubMed:24808098}.
Function -- GeneRIF ? help Back to Top
  1. ZFP8 is the direct target of ZFP5 in controlling epidermal cell differentiation.
    [PMID: 21803862]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT2G41940.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By gibberellin. {ECO:0000269|PubMed:17507408}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT1G66350 (R), AT2G01570 (A), AT2G36270 (R), AT3G03450 (R)
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G14920
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Reduced trichome production on cauline leaves, stem branches and sepals. {ECO:0000269|PubMed:17507408}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G41940
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0395970.0AY039597.1 Arabidopsis thaliana At2g41940/T6D20.16 mRNA, complete cds.
GenBankAY0560930.0AY056093.1 Arabidopsis thaliana At2g41940/T6D20.16 mRNA, complete cds.
GenBankCP0026850.0CP002685.1 Arabidopsis thaliana chromosome 2, complete sequence.
GenBankU904390.0U90439.3 Arabidopsis thaliana chromosome 2 BAC T6D20 genomic sequence, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_181725.10.0zinc finger protein 8
SwissprotP937510.0ZFP8_ARATH; Zinc finger protein 8
TrEMBLA0A178W1670.0A0A178W167_ARATH; ZFP8
STRINGAT2G41940.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM24951949
Representative plantOGRP285958
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  3. Czechowski T,Bari RP,Stitt M,Scheible WR,Udvardi MK
    Real-time RT-PCR profiling of over 1400 Arabidopsis transcription factors: unprecedented sensitivity reveals novel root- and shoot-specific genes.
    Plant J., 2004. 38(2): p. 366-79
    [PMID:15078338]
  4. Englbrecht CC,Schoof H,B
    Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.
    BMC Genomics, 2004. 5(1): p. 39
    [PMID:15236668]
  5. Ramonell K, et al.
    Loss-of-function mutations in chitin responsive genes show increased susceptibility to the powdery mildew pathogen Erysiphe cichoracearum.
    Plant Physiol., 2005. 138(2): p. 1027-36
    [PMID:15923325]
  6. Thilmony R,Underwood W,He SY
    Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7.
    Plant J., 2006. 46(1): p. 34-53
    [PMID:16553894]
  7. Gan Y,Liu C,Yu H,Broun P
    Integration of cytokinin and gibberellin signalling by Arabidopsis transcription factors GIS, ZFP8 and GIS2 in the regulation of epidermal cell fate.
    Development, 2007. 134(11): p. 2073-81
    [PMID:17507408]
  8. Gan Y,Yu H,Peng J,Broun P
    Genetic and molecular regulation by DELLA proteins of trichome development in Arabidopsis.
    Plant Physiol., 2007. 145(3): p. 1031-42
    [PMID:17704233]
  9. Ciftci-Yilmaz S,Mittler R
    The zinc finger network of plants.
    Cell. Mol. Life Sci., 2008. 65(7-8): p. 1150-60
    [PMID:18193167]
  10. Yu N, et al.
    Temporal control of trichome distribution by microRNA156-targeted SPL genes in Arabidopsis thaliana.
    Plant Cell, 2010. 22(7): p. 2322-35
    [PMID:20622149]
  11. Zhou Z, et al.
    Zinc finger protein5 is required for the control of trichome initiation by acting upstream of zinc finger protein8 in Arabidopsis.
    Plant Physiol., 2011. 157(2): p. 673-82
    [PMID:21803862]
  12. Gaudinier A, et al.
    Enhanced Y1H assays for Arabidopsis.
    Nat. Methods, 2011. 8(12): p. 1053-5
    [PMID:22037706]
  13. Causier B,Ashworth M,Guo W,Davies B
    The TOPLESS interactome: a framework for gene repression in Arabidopsis.
    Plant Physiol., 2012. 158(1): p. 423-38
    [PMID:22065421]
  14. Zhou Z,An L,Sun L,Gan Y
    ZFP5 encodes a functionally equivalent GIS protein to control trichome initiation.
    Plant Signal Behav, 2012. 7(1): p. 28-30
    [PMID:22301962]
  15. Zhou Z, et al.
    Zinc Finger Protein 6 (ZFP6) regulates trichome initiation by integrating gibberellin and cytokinin signaling in Arabidopsis thaliana.
    New Phytol., 2013. 198(3): p. 699-708
    [PMID:23506479]
  16. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  17. Joseph MP, et al.
    The Arabidopsis ZINC FINGER PROTEIN3 Interferes with Abscisic Acid and Light Signaling in Seed Germination and Plant Development.
    Plant Physiol., 2014. 165(3): p. 1203-1220
    [PMID:24808098]
  18. Mar
    Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners.
    Plant Physiol., 2014. 166(2): p. 1022-32
    [PMID:25118255]
  19. Sun L, et al.
    GLABROUS INFLORESCENCE STEMS3 (GIS3) regulates trichome initiation and development in Arabidopsis.
    New Phytol., 2015. 206(1): p. 220-30
    [PMID:25640859]
  20. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]
  21. Kim SY,Hyoung S,So WM,Shin JS
    The novel transcription factor TRP interacts with ZFP5, a trichome initiation-related transcription factor, and negatively regulates trichome initiation through gibberellic acid signaling.
    Plant Mol. Biol., 2018. 96(3): p. 315-326
    [PMID:29335898]
  22. Tague BW,Goodman HM
    Characterization of a family of Arabidopsis zinc finger protein cDNAs.
    Plant Mol. Biol., 1995. 28(2): p. 267-79
    [PMID:7599312]