PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G33835.1
Common NameFES1, T1B8
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C3H
Protein Properties Length: 587aa    MW: 64375.5 Da    PI: 6.4605
Description C3H family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G33835.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-CCCH20.67.9e-07101121526
                  --SGGGGTS--TTTTT-SS-SS CS
      zf-CCCH   5 lCrffartGtCkyGdrCkFaHg 26 
                  +C+ffa+ G+C  G +CkF H+
  AT2G33835.1 101 PCKFFAK-GWCFNGVSCKFLHV 121
                  7******.*************7 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF902296.02E-696120IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010314.31496123IPR000571Zinc finger, CCCH-type
Gene3DG3DSA:4.10.1000.109.3E-4101122IPR000571Zinc finger, CCCH-type
PfamPF006421.2E-4101121IPR000571Zinc finger, CCCH-type
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009908Biological Processflower development
GO:0010220Biological Processpositive regulation of vernalization response
GO:0030154Biological Processcell differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0046872Molecular Functionmetal ion binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000025anatomyroot tip
PO:0000037anatomyshoot apex
PO:0000293anatomyguard cell
PO:0009015anatomyportion of vascular tissue
Sequence ? help Back to Top
Protein Sequence    Length: 587 aa     Download sequence    Send to blast
MSDSDMDIDD DEVEQKVQVH TIVRESELFD KPPIQASNSH NDVKRHSVTT PLDEQSKIIK  60
EQAFAQDNGT LPRFPAPGIP PRSFFTGGGG NEPEQKRAAL PCKFFAKGWC FNGVSCKFLH  120
VKENSNCTSQ QLAENSMAGN GGIRSDLERR ILDSREGVRV SQLSENGVTS LPTREDISFM  180
NPQRVFSSMS FVNPPGSQRV FPFNNEMRFM PSFENIRRES LKQTYGADFT DNRSLVINNA  240
NSFALRSSFV HEHRPSISSY LKTDMGSAGP AWTGSLSSSV PMNDRASTVG DFENGNSLSG  300
SGSLPTLQGV AVSSDKGAEA NTTSTKKKVS SDDWEPSEPF KASFTIPPYI LPSSDALYDP  360
FTDIENLGDR PLNDSLSSKG EHARKSSCQQ KDGDSASGPQ ARDCKNDDKS SSCSQNQHQE  420
TVARSLEAHG VVEGVATSVV DQNDTATPSK EISSATAAEN RVVLKRIKPA GHDSWHRSDG  480
SSYKKTKKSD EIDGEVRSDA GMKVMRLFRT AVVETIKEML KPLWREGRLT KDVHNMIVKK  540
AAEKVVGAAV QFHQVPTDTE SVDQYLGLSG TRIVKLVEGY VEKYGKP
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.441170.0flower| leaf| seed| vegetative tissue
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1865051170.0
Expression AtlasAT2G33835-
AtGenExpressAT2G33835-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in root and shoot apices and vasculature. {ECO:0000269|PubMed:16291783}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a zinc finger domain containing protein that is expressed in the shoot/root apex and vasculature, and acts with FRI to repress flowering.FES1 mutants in a Col(FRI+) background will flower early under inductive conditions.
UniProtTranscriptional activator involved in the FRIGIDA-mediated vernalization pathway, but not in the autonomous flowering pathway. Acts cooperatively with FRI (FRIGIDA) or FRL1 (FRIGIDA-LIKE 1) to promote FLC (FLOWERING LOCUS C) expression. Required for the stabilization of the FRI-C complex. {ECO:0000269|PubMed:16291783, ECO:0000269|PubMed:21282526}.
Function -- GeneRIF ? help Back to Top
  1. Epistasis analysis between FES1, FRI and FRIGIDA-LIKE 1 (FRL1), indicates that these genes do not function in a linear pathway, but instead act cooperatively to promote the expression of FLC.
    [PMID: 16291783]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT2G33835.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT5G10140(A)
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G33835
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK2288660.0AK228866.1 Arabidopsis thaliana mRNA for zinc finger (CCCH type) protein - like, clone: RAFL16-19-E15.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_850221.10.0zinc finger domain protein FES1
SwissprotQ84VG70.0FES1_ARATH; Protein FRIGIDA-ESSENTIAL 1
TrEMBLD7LGF20.0D7LGF2_ARALL; Frigida-essential 1
STRINGAT2G33835.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP728179
MalvidsOGEM134681521
Publications ? help Back to Top
  1. Xiao YL,Malik M,Whitelaw CA,Town CD
    Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2 of Arabidopsis.
    Plant Physiol., 2002. 130(4): p. 2118-28
    [PMID:12481096]
  2. Schmitz RJ,Hong L,Michaels S,Amasino RM
    FRIGIDA-ESSENTIAL 1 interacts genetically with FRIGIDA and FRIGIDA-LIKE 1 to promote the winter-annual habit of Arabidopsis thaliana.
    Development, 2005. 132(24): p. 5471-8
    [PMID:16291783]
  3. Kim S,Choi K,Park C,Hwang HJ,Lee I
    SUPPRESSOR OF FRIGIDA4, encoding a C2H2-Type zinc finger protein, represses flowering by transcriptional activation of Arabidopsis FLOWERING LOCUS C.
    Plant Cell, 2006. 18(11): p. 2985-98
    [PMID:17138694]
  4. Proveniers M,Rutjens B,Brand M,Smeekens S
    The Arabidopsis TALE homeobox gene ATH1 controls floral competency through positive regulation of FLC.
    Plant J., 2007. 52(5): p. 899-913
    [PMID:17908157]
  5. Wang D, et al.
    Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.
    BMC Genomics, 2008. 9: p. 44
    [PMID:18221561]
  6. Choi K, et al.
    The FRIGIDA complex activates transcription of FLC, a strong flowering repressor in Arabidopsis, by recruiting chromatin modification factors.
    Plant Cell, 2011. 23(1): p. 289-303
    [PMID:21282526]
  7. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]