PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G22300.1
Common NameCAMTA3, CMTA3, SR1, T26C19.4
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family CAMTA
Protein Properties Length: 1032aa    MW: 116111 Da    PI: 5.2453
Description signal responsive 1
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G22300.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1CG-1182.54.8e-57201363118
         CG-1   3 ke.kkrwlkneeiaaiLenfekheltlelktrpksgsliLynrkkvryfrkDGyswkkkkdgktvrEdhekLKvggvevlycyYahseenptfqrrcy 99 
                  +e ++rwl++ ei++iL+n++++++++e++t+p+sgs+++++rk++ryfrkDG++w+kkkdgktv+E+he+LK g+v+vl+cyYah+++n++fqrr+y
  AT2G22300.1  20 SEaRHRWLRPPEICEILQNYQRFQISTEPPTTPSSGSVFMFDRKVLRYFRKDGHNWRKKKDGKTVKEAHERLKAGSVDVLHCYYAHGQDNENFQRRSY 117
                  4449********************************************************************************************** PP

         CG-1 100 wlLeeelekivlvhylevk 118
                  wlL+eel++iv+vhylevk
  AT2G22300.1 118 WLLQEELSHIVFVHYLEVK 136
                  ****************985 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5143782.70815141IPR005559CG-1 DNA-binding domain
SMARTSM010763.4E-8518136IPR005559CG-1 DNA-binding domain
PfamPF038591.0E-4921135IPR005559CG-1 DNA-binding domain
Gene3DG3DSA:2.60.40.107.5E-5463551IPR013783Immunoglobulin-like fold
SuperFamilySSF812965.76E-17465550IPR014756Immunoglobulin E-set
PfamPF018335.8E-4465550IPR002909IPT domain
SuperFamilySSF484032.8E-15636756IPR020683Ankyrin repeat-containing domain
CDDcd002044.02E-11641753No hitNo description
Gene3DG3DSA:1.25.40.203.9E-15641756IPR020683Ankyrin repeat-containing domain
PROSITE profilePS5029716.149644753IPR020683Ankyrin repeat-containing domain
PROSITE profilePS500889.164694726IPR002110Ankyrin repeat
SuperFamilySSF525403.72E-8849902IPR027417P-loop containing nucleoside triphosphate hydrolase
SMARTSM000150.92851873IPR000048IQ motif, EF-hand binding site
PROSITE profilePS500969.029853881IPR000048IQ motif, EF-hand binding site
PfamPF006120.0041854872IPR000048IQ motif, EF-hand binding site
SMARTSM000150.023874896IPR000048IQ motif, EF-hand binding site
PROSITE profilePS500969.066875899IPR000048IQ motif, EF-hand binding site
PfamPF006127.8E-4877896IPR000048IQ motif, EF-hand binding site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009409Biological Processresponse to cold
GO:0010150Biological Processleaf senescence
GO:0042742Biological Processdefense response to bacterium
GO:0045944Biological Processpositive regulation of transcription from RNA polymerase II promoter
GO:0050832Biological Processdefense response to fungus
GO:0005634Cellular Componentnucleus
GO:0001077Molecular Functiontranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0005516Molecular Functioncalmodulin binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000005anatomycultured plant cell
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 1032 aa     Download sequence    Send to blast
MAEARRFSPV HELDVGQILS EARHRWLRPP EICEILQNYQ RFQISTEPPT TPSSGSVFMF  60
DRKVLRYFRK DGHNWRKKKD GKTVKEAHER LKAGSVDVLH CYYAHGQDNE NFQRRSYWLL  120
QEELSHIVFV HYLEVKGSRV STSFNRMQRT EDAARSPQET GDALTSEHDG YASCSFNQND  180
HSNHSQTTDS ASVNGFHSPE LEDAESAYNQ HGSSTAYSHQ ELQQPATGGN LTGFDPYYQI  240
SLTPRDSYQK ELRTIPVTDS SIMVDKSKTI NSPGVTNGLK NRKSIDSQTW EEILGNCGSG  300
VEALPLQPNS EHEVLDQILE SSFTMQDFAS LQESMVKSQN QELNSGLTSD RTVWFQGQDM  360
ELNAISNLAS NEKAPYLSTM KQHLLHGALG EEGLKKMDSF NRWMSKELGD VGVIADANES  420
FTQSSSRTYW EEVESEDGSN GHNSRRDMDG YVMSPSLSKE QLFSINDFSP SWAYVGCEVV  480
VFVTGKFLKT REETEIGEWS CMFGQTEVPA DVISNGILQC VAPMHEAGRV PFYVTCSNRL  540
ACSEVREFEY KVAESQVFDR EADDESTIDI LEARFVKLLC SKSENTSPVS GNDSDLSQLS  600
EKISLLLFEN DDQLDQMLMN EISQENMKNN LLQEFLKESL HSWLLQKIAE GGKGPSVLDE  660
GGQGVLHFAA SLGYNWALEP TIIAGVSVDF RDVNGWTALH WAAFFGRERI IGSLIALGAA  720
PGTLTDPNPD FPSGSTPSDL AYANGHKGIA GYLSEYALRA HVSLLSLNDK NAETVEMAPS  780
PSSSSLTDSL TAVRNATQAA ARIHQVFRAQ SFQKKQLKEF GDKKLGMSEE RALSMLAPKT  840
HKSGRAHSDD SVQAAAIRIQ NKFRGYKGRK DYLITRQRII KIQAHVRGYQ FRKNYRKIIW  900
SVGVLEKVIL RWRRKGAGLR GFKSEALVEK MQDGTEKEED DDFFKQGRKQ TEDRLQKALA  960
RVKSMVQYPE ARDQYRRLLN VVNDIQESKV EKALENSEAT CFDDDDDLID IEALLEDDDT  1020
LMLPMSSSLW TS
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.485050.0flower| leaf| root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453615760.0
Genevisible263457_at0.0
Expression AtlasAT2G22300-
AtGenExpressAT2G22300-
ATTED-IIAT2G22300-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots, stems, leaves, carpels, and siliques, but not in stigmas or other parts of the flower. {ECO:0000269|PubMed:11162426, ECO:0000269|PubMed:12218065, ECO:0000269|PubMed:14581622}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a putative CAM binding transcription factor. Loss of function mutations show enhanced resistance to fungal and bacterial pathogens suggesting that CAMTA functions to suppress defense responses.
UniProtRegulates transcriptional activity in response to calcium signals. Binds to the consensus sequence 5'-[ACG]CGCG[GTC]-3'. {ECO:0000269|PubMed:11925432, ECO:0000269|PubMed:14581622}.
Function -- GeneRIF ? help Back to Top
  1. CAMTA3 regulates the expression of a set of genes involved in biotic defense responses.
    [PMID: 18298954]
  2. SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.
    [PMID: 22345509]
  3. Ca(2+)/Calmodulin-mediated signaling regulates plant response to herbivore attack/wounding by modulating the salicylic acid-jasmonic acid crosstalk through AtSR1.
    [PMID: 22371088]
  4. CAMTA1, CAMTA2 and CAMTA3 function together to inhibit salicylic acid biosynthesis at warm temperature (22 degrees C).CAMTA1, CAMTA2 and CAMTA3 function together to positively regulate CBF1, CBF2 and CBF3 and freezing tolerance.
    [PMID: 23581962]
  5. double mekk1/camta3 mutant positioned CAMTA3 downstream of MEKK1 and verified their distinct roles in GSR regulation. mekk1-5 displays programmed cell death and overaccumulates reactive oxygen species and salicylic acid
    [PMID: 25157030]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00042PBM25215497Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT2G22300.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By temperature, UVB, salt, wounding, ethylene and methyl jasmonate. {ECO:0000269|PubMed:11162426, ECO:0000269|PubMed:12218065}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT2G01570 (A)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT3G48090(R), AT4G25470(A)
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G22300
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0024590.0BT002459.1 Arabidopsis thaliana Unknown protein mRNA, complete cds.
GenBankAY5100250.0AY510025.1 Arabidopsis thaliana ethylene-induced calmodulin-binding protein 1 mRNA, complete cds.
GenBankAF5066970.0AF506697.1 Arabidopsis thaliana calmodulin-binding transcription factor SR1 (SR1) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001118361.10.0calmodulin-binding transcription activator 3
RefseqNP_850023.10.0calmodulin-binding transcription activator 3
SwissprotQ8GSA70.0CMTA3_ARATH; Calmodulin-binding transcription activator 3
TrEMBLQ0WW700.0Q0WW70_ARATH; Calmodulin-binding transcription activator 3
STRINGAT2G22300.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP5621565
MalvidsOGEM86012535
Publications ? help Back to Top
  1. Reddy AS,Reddy VS,Golovkin M
    A calmodulin binding protein from Arabidopsis is induced by ethylene and contains a DNA-binding motif.
    Biochem. Biophys. Res. Commun., 2000. 279(3): p. 762-9
    [PMID:11162426]
  2. Reddy VS,Ali GS,Reddy AS
    Genes encoding calmodulin-binding proteins in the Arabidopsis genome.
    J. Biol. Chem., 2002. 277(12): p. 9840-52
    [PMID:11782485]
  3. Bouch
    A novel family of calmodulin-binding transcription activators in multicellular organisms.
    J. Biol. Chem., 2002. 277(24): p. 21851-61
    [PMID:11925432]
  4. Yang T,Poovaiah BW
    A calmodulin-binding/CGCG box DNA-binding protein family involved in multiple signaling pathways in plants.
    J. Biol. Chem., 2002. 277(47): p. 45049-58
    [PMID:12218065]
  5. Mitsuda N,Isono T,Sato MH
    Arabidopsis CAMTA family proteins enhance V-PPase expression in pollen.
    Plant Cell Physiol., 2003. 44(10): p. 975-81
    [PMID:14581622]
  6. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  7. Galon Y, et al.
    Calmodulin-binding transcription activator (CAMTA) 3 mediates biotic defense responses in Arabidopsis.
    FEBS Lett., 2008. 582(6): p. 943-8
    [PMID:18298954]
  8. Hou X, et al.
    Global identification of DELLA target genes during Arabidopsis flower development.
    Plant Physiol., 2008. 147(3): p. 1126-42
    [PMID:18502975]
  9. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  10. Du L, et al.
    Ca(2+)/calmodulin regulates salicylic-acid-mediated plant immunity.
    Nature, 2009. 457(7233): p. 1154-8
    [PMID:19122675]
  11. Jones AM, et al.
    Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana.
    J Proteomics, 2009. 72(3): p. 439-51
    [PMID:19245862]
  12. Eckardt NA
    CAMTA proteins: a direct link between calcium signals and cold acclimation?
    Plant Cell, 2009. 21(3): p. 697
    [PMID:19270185]
  13. Doherty CJ,Van Buskirk HA,Myers SJ,Thomashow MF
    Roles for Arabidopsis CAMTA transcription factors in cold-regulated gene expression and freezing tolerance.
    Plant Cell, 2009. 21(3): p. 972-84
    [PMID:19270186]
  14. Walley JW,Dehesh K
    Molecular mechanisms regulating rapid stress signaling networks in Arabidopsis.
    J Integr Plant Biol, 2010. 52(4): p. 354-9
    [PMID:20377697]
  15. Shin R,Jez JM,Basra A,Zhang B,Schachtman DP
    14-3-3 proteins fine-tune plant nutrient metabolism.
    FEBS Lett., 2011. 585(1): p. 143-7
    [PMID:21094157]
  16. Jing B, et al.
    Brush and spray: a high-throughput systemic acquired resistance assay suitable for large-scale genetic screening.
    Plant Physiol., 2011. 157(3): p. 973-80
    [PMID:21900483]
  17. Nie H, et al.
    SR1, a calmodulin-binding transcription factor, modulates plant defense and ethylene-induced senescence by directly regulating NDR1 and EIN3.
    Plant Physiol., 2012. 158(4): p. 1847-59
    [PMID:22345509]
  18. Qiu Y,Xi J,Du L,Suttle JC,Poovaiah BW
    Coupling calcium/calmodulin-mediated signaling and herbivore-induced plant response through calmodulin-binding transcription factor AtSR1/CAMTA3.
    Plant Mol. Biol., 2012. 79(1-2): p. 89-99
    [PMID:22371088]
  19. Curran A, et al.
    Calcium-dependent protein kinases from Arabidopsis show substrate specificity differences in an analysis of 103 substrates.
    Front Plant Sci, 2011. 2: p. 36
    [PMID:22645532]
  20. Laluk K, et al.
    The calmodulin-binding transcription factor SIGNAL RESPONSIVE1 is a novel regulator of glucosinolate metabolism and herbivory tolerance in Arabidopsis.
    Plant Cell Physiol., 2012. 53(12): p. 2008-15
    [PMID:23072934]
  21. Kim Y,Park S,Gilmour SJ,Thomashow MF
    Roles of CAMTA transcription factors and salicylic acid in configuring the low-temperature transcriptome and freezing tolerance of Arabidopsis.
    Plant J., 2013. 75(3): p. 364-76
    [PMID:23581962]
  22. Bjornson M, et al.
    Distinct roles for mitogen-activated protein kinase signaling and CALMODULIN-BINDING TRANSCRIPTIONAL ACTIVATOR3 in regulating the peak time and amplitude of the plant general stress response.
    Plant Physiol., 2014. 166(2): p. 988-96
    [PMID:25157030]
  23. Waidmann S,Kusenda B,Mayerhofer J,Mechtler K,Jonak C
    A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis.
    Plant Cell, 2014. 26(11): p. 4328-44
    [PMID:25387881]
  24. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]