PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G72360.1
Common NameAtERF73, ERF073, ERF73, HRE1, T10D10.17
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 211aa    MW: 23661.2 Da    PI: 4.5542
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G72360.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP263.54.6e-202374156
          AP2  1 sgykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkklege 56
                 s+ykG+r+++ +grW+AeIrdp     +  r++lg+f taeeAa+a++  +k+++g+
  AT1G72360.1 23 SRYKGIRRRP-WGRWAAEIRDPI----KgVRVWLGTFNTAEEAARAYDLEAKRIRGA 74
                 79********.**********72....46*************************985 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541719.81E-232382IPR016177DNA-binding domain
CDDcd000183.55E-332382No hitNo description
PfamPF008471.5E-132373IPR001471AP2/ERF domain
SMARTSM003806.6E-372487IPR001471AP2/ERF domain
PROSITE profilePS5103224.1442481IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.109.9E-312482IPR001471AP2/ERF domain
PRINTSPR003673.8E-112536IPR001471AP2/ERF domain
PRINTSPR003673.8E-114763IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009873Biological Processethylene-activated signaling pathway
GO:0034059Biological Processresponse to anoxia
GO:0071456Biological Processcellular response to hypoxia
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0009005anatomyroot
PO:0009025anatomyvascular leaf
PO:0009030anatomycarpel
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0020030anatomycotyledon
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 211 aa     Download sequence    Send to blast
MSQSFELYPW LGSASDGKKK QSSRYKGIRR RPWGRWAAEI RDPIKGVRVW LGTFNTAEEA  60
ARAYDLEAKR IRGAKAKLNF PNESSGKRKA KAKTVQQVEE NHEADLDVAV VSSAPSSSCL  120
DFLWEENNPD TLLIDTQWLE DIIMGDANKK HEPNDSEEAN NVDASLLSEE LLAFENQTEY  180
FSQMPFTEGN CDSSTSLSSL FDGGNDMGLW S
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5wx9_A2e-2121831174Ethylene-responsive transcription factor ERF096
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
11730KKKQSSRYKGIRRR
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306988680.0
Genevisible260451_at0.0
Expression AtlasAT1G72360-
AtGenExpressAT1G72360-
ATTED-IIAT1G72360-
Functional Description ? help Back to Top
Source Description
TAIRencodes a member of the ERF (ethylene response factor) subfamily B-2 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 5 members in this subfamily including RAP2.2 AND RAP2.12.
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. rotein localized in the nucleus and functioned as an in vivo transcription activator as confirmed in transient assays and experiments.
    [PMID: 15980186]
  2. HRE1 and HRE2 encode two nuclear-localized ethylene response factors specifically up-regulated under low oxygen conditions.
    [PMID: 20113439]
  3. AtERF73/HRE1 is involved in modulating ethylene responses under both normoxia and hypoxia.
    [PMID: 21398256]
  4. controlled by 3 pathways during hypoxia: an ethylene-dependent pathway, an ethylene-independent/H 2O 2-dependent pathway, and an ethylene and H 2O 2-independent pathway
    [PMID: 24698791]
  5. HRE1alpha functions as a transcription activator in the nucleus, and plays an important role in root development through regulation of root meristem cell division.
    [PMID: 24728113]
  6. AtERF73/HRE1 plays a role in H2O2 production by affecting the hypoxia-induced expression of Rboh genes in hypoxia signal transduction.
    [PMID: 27995331]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00230DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G72360.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDethylene
Interaction ? help Back to Top
Source Intact With
IntActSearch Q8H0T5
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G72360
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0165290.0AC016529.7 Arabidopsis thaliana chromosome 1 BAC T10D10 genomic sequence, complete sequence.
GenBankBT0020630.0BT002063.1 Arabidopsis thaliana putative AP2 domain transcription factor (At1g72360) mRNA, complete cds.
GenBankBT0062590.0BT006259.1 Arabidopsis thaliana At1g72360 mRNA, complete cds.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_177380.21e-156Integrase-type DNA-binding superfamily protein
SwissprotQ8H0T51e-157ERF73_ARATH; Ethylene-responsive transcription factor ERF073
TrEMBLA0A178W8F11e-144A0A178W8F1_ARATH; HRE1
TrEMBLF4IDA71e-144F4IDA7_ARATH; Integrase-type DNA-binding superfamily protein
STRINGAT1G72360.21e-145(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  3. Shin R,Schachtman DP
    Hydrogen peroxide mediates plant root cell response to nutrient deprivation.
    Proc. Natl. Acad. Sci. U.S.A., 2004. 101(23): p. 8827-32
    [PMID:15173595]
  4. Sahr T,Voigt G,Paretzke HG,Schramel P,Ernst D
    Caesium-affected gene expression in Arabidopsis thaliana.
    New Phytol., 2005. 165(3): p. 747-54
    [PMID:15720685]
  5. Nawy T, et al.
    Transcriptional profile of the Arabidopsis root quiescent center.
    Plant Cell, 2005. 17(7): p. 1908-25
    [PMID:15937229]
  6. Ogawa T, et al.
    Functional analysis of Arabidopsis ethylene-responsive element binding protein conferring resistance to Bax and abiotic stress-induced plant cell death.
    Plant Physiol., 2005. 138(3): p. 1436-45
    [PMID:15980186]
  7. Nakayama N, et al.
    Gene trap lines define domains of gene regulation in Arabidopsis petals and stamens.
    Plant Cell, 2005. 17(9): p. 2486-506
    [PMID:16055634]
  8. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
    [PMID:16407444]
  9. Licausi F, et al.
    HRE1 and HRE2, two hypoxia-inducible ethylene response factors, affect anaerobic responses in Arabidopsis thaliana.
    Plant J., 2010. 62(2): p. 302-15
    [PMID:20113439]
  10. Licausi F, et al.
    Hypoxia responsive gene expression is mediated by various subsets of transcription factors and miRNAs that are determined by the actual oxygen availability.
    New Phytol., 2011. 190(2): p. 442-56
    [PMID:20840511]
  11. Yang CY,Hsu FC,Li JP,Wang NN,Shih MC
    The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis.
    Plant Physiol., 2011. 156(1): p. 202-12
    [PMID:21398256]
  12. Hess N,Klode M,Anders M,Sauter M
    The hypoxia responsive transcription factor genes ERF71/HRE2 and ERF73/HRE1 of Arabidopsis are differentially regulated by ethylene.
    Physiol Plant, 2011. 143(1): p. 41-9
    [PMID:21615413]
  13. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  14. Gibbs DJ, et al.
    Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants.
    Nature, 2011. 479(7373): p. 415-8
    [PMID:22020279]
  15. Yang CY
    Ethylene and hydrogen peroxide are involved in hypoxia signaling that modulates AtERF73/HRE1 expression.
    Plant Signal Behav, 2014. 9(3): p. e28583
    [PMID:24698791]
  16. Seok HY,Tarte VN,Lee SY,Park HY,Moon YH
    Arabidopsis HRE1α, a splicing variant of AtERF73/HRE1, functions as a nuclear transcription activator in hypoxia response and root development.
    Plant Cell Rep., 2014. 33(8): p. 1255-62
    [PMID:24728113]
  17. Yang CY,Huang YC,Ou SL
    ERF73/HRE1 is involved in H2O2 production via hypoxia-inducible Rboh gene expression in hypoxia signaling.
    Protoplasma, 2017. 254(4): p. 1705-1714
    [PMID:27995331]
  18. Riechmann JL,Meyerowitz EM
    The AP2/EREBP family of plant transcription factors.
    Biol. Chem., 1998. 379(6): p. 633-46
    [PMID:9687012]