PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G67260.2
Common NameTCP1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family TCP
Protein Properties Length: 351aa    MW: 39797.3 Da    PI: 5.0807
Description TCP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G67260.2genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1TCP129.53.4e-40852392135
          TCP   2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgt...ssssa...sec.......eaesssssasnss 86 
                   +kkdrhski T++g RdRRvRls+ +a++fFdLqd+LGfdk+skt++WLl+++ +aike ++    +   +     +       e+e+++++++n  
  AT1G67260.2  85 VVKKDRHSKIQTAQGIRDRRVRLSIGIARQFFDLQDMLGFDKASKTLDWLLKKSRKAIKEVVQAknlN---NddeD-FgniggdvEQEEEKEEDDN-- 176
                  589*************************************************************5552...42321.2344433244444444443.. PP

          TCP  87 sg..............kaaksaakskksqksaasalnlak.esrakarararertrekmriknk 135
                   g              ++   +a++   +k++++ +n++     akar +a+ert+e m+ +n 
  AT1G67260.2 177 -GdksfvyglspgygeEEVVCEATKAGIRKKKSELRNISSkGLGAKARGKAKERTKEMMAYDNP 239
                  .1345889999999985555555555555555556777664677***************98865 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF036341.8E-3787234IPR005333Transcription factor, TCP
PROSITE profilePS5136934.21887145IPR017887Transcription factor TCP subgroup
PROSITE profilePS513708.677216233IPR017888CYC/TB1, R domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009908Biological Processflower development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000229anatomyflower meristem
PO:0007601developmental stagefloral organ meristem development stage
PO:0007602developmental stagefloral organ primordium development stage
Sequence ? help Back to Top
Protein Sequence    Length: 351 aa     Download sequence    Send to blast
MSSSTNDYND GNNNGVYPLS LYLSSLSGHQ DIIHNPYNHQ LKASPGHMVS AVPESLIDYM  60
AFKSNNVVNQ QGFEFPEVSK EIKKVVKKDR HSKIQTAQGI RDRRVRLSIG IARQFFDLQD  120
MLGFDKASKT LDWLLKKSRK AIKEVVQAKN LNNDDEDFGN IGGDVEQEEE KEEDDNGDKS  180
FVYGLSPGYG EEEVVCEATK AGIRKKKSEL RNISSKGLGA KARGKAKERT KEMMAYDNPE  240
TASDITQSEI MDPFKRSIVF NEGEDMTHLF YKEPIEEFDN QESILTNMTL PTKMGQSYNQ  300
NNGILMLVDQ SSSSNYNTFL PQNLDYSYDQ NPFHDQTLYV VTDKNFPKGF L
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5zkt_A8e-1492145154Putative transcription factor PCF6
5zkt_B8e-1492145154Putative transcription factor PCF6
Search in ModeBase
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasAT1G67260
AtGenExpressAT1G67260
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed transiently in early stages of floral meristems development but continuously in axillary shoot meristems, specifically in the dorsal part (adaxial). {ECO:0000269|PubMed:11470410}.
UniprotTISSUE SPECIFICITY: Axillary shoot and floral meristems. {ECO:0000269|PubMed:11470410}.
Functional Description ? help Back to Top
Source Description
TAIREncodes protein with TCP (TB1,CYC,PCF) domain which is likely to be involved in DNA binding and protein-protein interactions. Based on genome analysis, there is a 9-member gene family that possesses this domain in Arabidopsis. Orthologue of Antirrhinum gene CYCLOIDEA.
UniProtInvolved in petal morphogenesis. {ECO:0000269|PubMed:17940055}.
Function -- GeneRIF ? help Back to Top
  1. TCP1 positively regulates the expression of the key brassinosteroid biosynthetic gene, DWF4.
    [PMID: 20435901]
  2. important roles of Arabidopsis TCP1 in the longitudinal elongation of petioles, rosette leaves and inflorescent stems
    [PMID: 20944404]
  3. TCP1 positively regulates BR biosynthesis via its direct regulation of the transcription of DWF4.
    [PMID: 21822059]
  4. Data indicate that transcription factors TCP-NGA regulatory interaction is likely conserved in angiosperms, including important crop species.
    [PMID: 25625546]
  5. TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis thaliana
    [PMID: 26233893]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00215DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G67260.2
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT3G50660(A)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDBrassinosteroid
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G67260
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0021300.0AC002130.2 Genomic sequence for Arabidopsis thaliana BAC F1N21 from chromosome I, complete sequence.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001154454.10.0TCP family transcription factor
RefseqNP_001322103.10.0TCP family transcription factor
SwissprotQ9FYG70.0TCP1_ARATH; Transcription factor TCP1
TrEMBLF4HRT70.0F4HRT7_ARATH; TCP family transcription factor
STRINGAT1G67260.10.0(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Cubas P,Lauter N,Doebley J,Coen E
    The TCP domain: a motif found in proteins regulating plant growth and development.
    Plant J., 1999. 18(2): p. 215-22
    [PMID:10363373]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. Cubas P,Coen E,Zapater JM
    Ancient asymmetries in the evolution of flowers.
    Curr. Biol., 2001. 11(13): p. 1050-2
    [PMID:11470410]
  4. Citerne HL,Luo D,Pennington RT,Coen E,Cronk QC
    A phylogenomic investigation of CYCLOIDEA-like TCP genes in the Leguminosae.
    Plant Physiol., 2003. 131(3): p. 1042-53
    [PMID:12644657]
  5. Damerval C,Le Guilloux M,Jager M,Charon C
    Diversity and evolution of CYCLOIDEA-like TCP genes in relation to flower development in Papaveraceae.
    Plant Physiol., 2007. 143(2): p. 759-72
    [PMID:17189327]
  6. Finlayson SA
    Arabidopsis Teosinte Branched1-like 1 regulates axillary bud outgrowth and is homologous to monocot Teosinte Branched1.
    Plant Cell Physiol., 2007. 48(5): p. 667-77
    [PMID:17452340]
  7. Busch A,Zachgo S
    Control of corolla monosymmetry in the Brassicaceae Iberis amara.
    Proc. Natl. Acad. Sci. U.S.A., 2007. 104(42): p. 16714-9
    [PMID:17940055]
  8. Guo Z, et al.
    TCP1 modulates brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana.
    Plant Cell, 2010. 22(4): p. 1161-73
    [PMID:20435901]
  9. Koyama T,Sato F,Ohme-Takagi M
    A role of TCP1 in the longitudinal elongation of leaves in Arabidopsis.
    Biosci. Biotechnol. Biochem., 2010. 74(10): p. 2145-7
    [PMID:20944404]
  10. An J,Guo Z,Gou X,Li J
    TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana.
    Plant Signal Behav, 2011. 6(8): p. 1117-8
    [PMID:21822059]
  11. Yang X, et al.
    Evolution of double positive autoregulatory feedback loops in CYCLOIDEA2 clade genes is associated with the origin of floral zygomorphy.
    Plant Cell, 2012. 24(5): p. 1834-47
    [PMID:22649271]
  12. Meinke DW
    A survey of dominant mutations in Arabidopsis thaliana.
    Trends Plant Sci., 2013. 18(2): p. 84-91
    [PMID:22995285]
  13. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  14. Mar
    Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners.
    Plant Physiol., 2014. 166(2): p. 1022-32
    [PMID:25118255]
  15. Chen GH,Sun JY,Liu M,Liu J,Yang WC
    SPOROCYTELESS is a novel embryophyte-specific transcription repressor that interacts with TPL and TCP proteins in Arabidopsis.
    J Genet Genomics, 2014. 41(12): p. 617-25
    [PMID:25527103]
  16. Ballester P,Navarrete-G
    Leaf expansion in Arabidopsis is controlled by a TCP-NGA regulatory module likely conserved in distantly related species.
    Physiol Plant, 2015. 155(1): p. 21-32
    [PMID:25625546]
  17. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]
  18. Gao Y,Zhang D,Li J
    TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis thaliana.
    J Genet Genomics, 2015. 42(7): p. 383-92
    [PMID:26233893]
  19. Mazur MJ, et al.
    Arabidopsis TCP Transcription Factors Interact with the SUMO Conjugating Machinery in Nuclear Foci.
    Front Plant Sci, 2017. 8: p. 2043
    [PMID:29250092]