PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G49950.3
Common NameATTRB1, F2J10.16, TRB1
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family MYB_related
Protein Properties Length: 300aa    MW: 33016.6 Da    PI: 9.9053
Description telomere repeat binding factor 1
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G49950.3genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
  Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmg.....kgRtlkqcksrwqk 46
                     +++WT+eE+  l+ +v ++G+g W+tI +          R+  ++k++w++
                     79***********************************88***********9 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5129411.594158IPR017930Myb domain
SMARTSM007175.4E-7459IPR001005SANT/Myb domain
PfamPF002491.2E-8555IPR001005SANT/Myb domain
CDDcd116608.16E-18656No hitNo description
SMARTSM005263.3E-13113180IPR005818Linker histone H1/H5, domain H15
SuperFamilySSF467852.94E-15116193IPR011991Winged helix-turn-helix DNA-binding domain
PROSITE profilePS5150422.895117185IPR005818Linker histone H1/H5, domain H15
Gene3DG3DSA: helix-turn-helix DNA-binding domain
PfamPF005382.1E-7122178IPR005818Linker histone H1/H5, domain H15
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006334Biological Processnucleosome assembly
GO:0006357Biological Processregulation of transcription from RNA polymerase II promoter
GO:0009651Biological Processresponse to salt stress
GO:0009723Biological Processresponse to ethylene
GO:0009733Biological Processresponse to auxin
GO:0009737Biological Processresponse to abscisic acid
GO:0009739Biological Processresponse to gibberellin
GO:0009751Biological Processresponse to salicylic acid
GO:0009753Biological Processresponse to jasmonic acid
GO:0031627Biological Processtelomeric loop formation
GO:0046686Biological Processresponse to cadmium ion
GO:0000784Cellular Componentnuclear chromosome, telomeric region
GO:0000785Cellular Componentchromatin
GO:0000786Cellular Componentnucleosome
GO:0005730Cellular Componentnucleolus
GO:0003691Molecular Functiondouble-stranded telomeric DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0033613Molecular Functionactivating transcription factor binding
GO:0042803Molecular Functionprotein homodimerization activity
GO:0070491Molecular Functionrepressing transcription factor binding
GO:1990841Molecular Functionpromoter-specific chromatin binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009025anatomyvascular leaf
PO:0009052anatomyflower pedicel
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025195anatomypollen tube cell
PO:0001017developmental stageM germinated pollen stage
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 300 aa     Download sequence    Send to blast
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.272500.0flower| leaf| vegetative tissue
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT1G49950-
Functional Description ? help Back to Top
Source Description
TAIREncodes a telomeric DNA binding protein. In vitro, an N-terminal Myb domain enables it to interact with double-stranded telomeric repeats.
UniProtBinds preferentially double-stranded telomeric repeats. {ECO:0000269|PubMed:19102728}.
Function -- GeneRIF ? help Back to Top
  1. The domains responsible for that interaction AtTRB1 and AtPOT1b were identified.
    [PMID: 18387366]
  2. DNA-protein interaction of the full-length and truncated variants of AtTRB1, a Single-Myb-Histone-family member with a typical structure
    [PMID: 18479720]
  3. AtTRB1 is highly dynamic during interphase. The histone-like domain and the Myb domain can both direct the protein to the nucleolus.
    [PMID: 19947985]
  4. TRB1 shows a specific genome-wide distribution pattern which suggests its role in regulation of genes involved in biogenesis of the translational machinery, in addition to its preferential telomeric localization.
    [PMID: 26597966]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDabscisic acid, auxin, ethylene, gibberellin, jasmonic acid, salicylic acid
Interaction -- BIND ? help Back to Top
Source Intact With Description
BINDAT1G49950TRB1 interacts with another molecule of TRB1.
Interaction ? help Back to Top
Source Intact With
IntActSearch Q8VWK4
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G49950
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0627360.0AY062736.1 Arabidopsis thaliana Unknown protein (At1g49950; F2J10.16) mRNA, complete cds.
GenBankAY5195390.0AY519539.1 Arabidopsis thaliana MYB transcription factor (At1g49950) mRNA, complete cds.
GenBankBT0096770.0BT009677.1 Arabidopsis thaliana At1g49950 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_564559.10.0telomere repeat binding factor 1
RefseqNP_849789.10.0telomere repeat binding factor 1
RefseqNP_973998.10.0telomere repeat binding factor 1
SwissprotQ8VWK40.0TRB1_ARATH; Telomere repeat-binding factor 1
STRINGAT1G49950.30.0(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  2. Marian CO, et al.
    The maize Single myb histone 1 gene, Smh1, belongs to a novel gene family and encodes a protein that binds telomere DNA repeats in vitro.
    Plant Physiol., 2003. 133(3): p. 1336-50
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  4. Wierzbicki AT,Jerzmanowski A
    Suppression of histone H1 genes in Arabidopsis results in heritable developmental defects and stochastic changes in DNA methylation.
    Genetics, 2005. 169(2): p. 997-1008
  5. Kuchar M,Fajkus J
    Interactions of putative telomere-binding proteins in Arabidopsis thaliana: identification of functional TRF2 homolog in plants.
    FEBS Lett., 2004. 578(3): p. 311-5
  6. Alexandrov NN, et al.
    Features of Arabidopsis genes and genome discovered using full-length cDNAs.
    Plant Mol. Biol., 2006. 60(1): p. 69-85
  7. Yanhui C, et al.
    The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family.
    Plant Mol. Biol., 2006. 60(1): p. 107-24
  8. Broekgaarden C, et al.
    Genotypic variation in genome-wide transcription profiles induced by insect feeding: Brassica oleracea--Pieris rapae interactions.
    BMC Genomics, 2007. 8: p. 239
  9. Schrumpfov
    Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana.
    FEBS Lett., 2008. 582(10): p. 1400-6
  10. Mozgová I,Schrumpfová PP,Hofr C,Fajkus J
    Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana.
    Phytochemistry, 2008. 69(9): p. 1814-9
  11. Wang Y, et al.
    Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
    Plant Physiol., 2008. 148(3): p. 1201-11
  12. Hofr C, et al.
    Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specificity and kinetics.
    Biochem. J., 2009. 419(1): p. 221-8, 2 p following 228
  13. Dvorácková M, et al.
    AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin.
    Plant J., 2010. 61(4): p. 637-49
  14. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
  15. Schrumpfová PP, et al.
    Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase.
    Plant J., 2014. 77(5): p. 770-81
  16. Schrumpfov
    Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo.
    Plant Mol. Biol., 2016. 90(1-2): p. 189-206
  17. Liang SC, et al.
    Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2.
    PLoS Genet., 2015. 11(12): p. e1005660
  18. Zhou Y,Hartwig B,James GV,Schneeberger K,Turck F
    Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes.
    Plant Cell, 2016. 28(1): p. 87-101
  19. Fulcher N,Riha K
    Using Centromere Mediated Genome Elimination to Elucidate the Functional Redundancy of Candidate Telomere Binding Proteins in Arabidopsis thaliana.
    Front Genet, 2015. 6: p. 349
  20. Kotliński M, et al.
    Phylogeny-Based Systematization of Arabidopsis Proteins with Histone H1 Globular Domain.
    Plant Physiol., 2017. 174(1): p. 27-34