PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G32640.1
Common NameATMYC2, BHLH6, EN38, F6N18.4, JAI1, JIN1, MYC2, RAP1, RD22BP1, ZBF1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 623aa    MW: 67949.8 Da    PI: 5.0247
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G32640.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH391.5e-12452497454
                  HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                  +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  AT1G32640.1 452 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAIAYINEL 497
                  799***********************6.....5***************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142152.3E-5668252IPR025610Transcription factor MYC/MYB N-terminal
SuperFamilySSF474597.07E-17447514IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088817.111448497IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.34E-14451501No hitNo description
PfamPF000105.1E-10452497IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.103.5E-17452518IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003538.2E-16454503IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009269Biological Processresponse to desiccation
GO:0009611Biological Processresponse to wounding
GO:0009737Biological Processresponse to abscisic acid
GO:0009738Biological Processabscisic acid-activated signaling pathway
GO:0009867Biological Processjasmonic acid mediated signaling pathway
GO:0009963Biological Processpositive regulation of flavonoid biosynthetic process
GO:0010200Biological Processresponse to chitin
GO:0043619Biological Processregulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051090Biological Processregulation of sequence-specific DNA binding transcription factor activity
GO:2000068Biological Processregulation of defense response to insect
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000005anatomycultured plant cell
PO:0000013anatomycauline leaf
PO:0000017anatomyvascular leaf primordium
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000256anatomyroot hair cell
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025195anatomypollen tube cell
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 623 aa     Download sequence    Send to blast
MTDYRLQPTM NLWTTDDNAS MMEAFMSSSD ISTLWPPAST TTTTATTETT PTPAMEIPAQ  60
AGFNQETLQQ RLQALIEGTH EGWTYAIFWQ PSYDFSGASV LGWGDGYYKG EEDKANPRRR  120
SSSPPFSTPA DQEYRKKVLR ELNSLISGGV APSDDAVDEE VTDTEWFFLV SMTQSFACGA  180
GLAGKAFATG NAVWVSGSDQ LSGSGCERAK QGGVFGMHTI ACIPSANGVV EVGSTEPIRQ  240
SSDLINKVRI LFNFDGGAGD LSGLNWNLDP DQGENDPSMW INDPIGTPGS NEPGNGAPSS  300
SSQLFSKSIQ FENGSSSTIT ENPNLDPTPS PVHSQTQNPK FNNTFSRELN FSTSSSTLVK  360
PRSGEILNFG DEGKRSSGNP DPSSYSGQTQ FENKRKRSMV LNEDKVLSFG DKTAGESDHS  420
DLEASVVKEV AVEKRPKKRG RKPANGREEP LNHVEAERQR REKLNQRFYA LRAVVPNVSK  480
MDKASLLGDA IAYINELKSK VVKTESEKLQ IKNQLEEVKL ELAGRKASAS GGDMSSSCSS  540
IKPVGMEIEV KIIGWDAMIR VESSKRNHPA ARLMSALMDL ELEVNHASMS VVNDLMIQQA  600
TVKMGFRIYT QEQLRASLIS KIG
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yz6_A2e-73602551195Transcription factor MYC3
4rs9_A2e-73602551195Transcription factor MYC3
4rqw_B2e-73602551195Transcription factor MYC3
4rqw_A2e-73602551195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1433441KRPKKRGRK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.226480.0flower| inflorescence| leaf| root| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible261713_at0.0
Expression AtlasAT1G32640-
AtGenExpressAT1G32640-
ATTED-IIAT1G32640-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Widely expressed in the whole plant with the highest expression in stem. Constitutively expressed in dark- and light-grown seedlings. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15923349}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a MYC-related transcriptional activator with a typical DNA binding domain of a basic helix-loop-helix leucine zipper motif. Binds to an extended G-Box promoter motif. Its transcription is induced by dehydration stress and ABA treatment. Negative regulator of blue lightmediated photomorphogenic growth and blue and far-red-lightregulated gene expression. Positive regulator of lateral root formation. Regulates diverse JA-dependent functions. Negatively regulates Trp metabolism and biosynthesis of Trp-derived secondary metabolites. Positively regulates flavonoid biosynthesis, resistance to insects, and response to oxidative stress. Regulates other transcription factors, and negatively regulates its own expression.
UniProtTranscriptional activator. Common transcription factor of light, abscisic acid (ABA), and jasmonic acid (JA) signaling pathways. With MYC3 and MYC4, controls additively subsets of JA-dependent responses. In cooperation with MYB2 is involved in the regulation of ABA-inducible genes under drought stress conditions. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the MYC recognition site (5'-CACATG-3'), and to the G-box (5'-CACNTG-3') and Z-box (5'-ATACGTGT-3') of promoters. Binds directly to the promoters of the transcription factors PLETHORA1 (PLT1) and PLT2 and represses their expression. Negative regulator of blue light-mediated photomorphogenic growth and blue- and far-red-light regulated gene expression. Activates multiple TIFY/JAZ promoters. Positive regulator of lateral root formation. Regulates sesquiterpene biosynthesis. Subjected to proteasome-dependent proteolysis. The presence of the destruction element (DE) involved in turnover is required for the function to regulate gene transcription. {ECO:0000269|PubMed:12509522, ECO:0000269|PubMed:15208388, ECO:0000269|PubMed:15923349, ECO:0000269|PubMed:21321051, ECO:0000269|PubMed:21335373, ECO:0000269|PubMed:21954460, ECO:0000269|PubMed:22669881, ECO:0000269|PubMed:23142764, ECO:0000269|PubMed:23593022, ECO:0000269|PubMed:23943862, ECO:0000269|PubMed:9368419}.
Function -- GeneRIF ? help Back to Top
  1. The role of jasmonate and salicylic acid signaling in susceptibility to P. syringae infection in A. thaliana mutants is reported.
    [PMID: 16838791]
  2. These results provide new insights into the function of MYC2 and the transcriptional coordination of the jasmonic acid signaling pathway.
    [PMID: 17616737]
  3. results pinpoint MYC2 as a potential regulator in priming for enhanced JA-responsive gene expression during rhizobacteria-mediated ISR
    [PMID: 18657213]
  4. MYC2 and SPA1 act redundantly to suppress photomorphogenic growth in the dark.
    [PMID: 20864543]
  5. High- and medium-affinity binding sites are over-represented in promoters of MYC2- or ERF1 (ethylene-responsive transcription factor 1B)-regulated genes, and therefore they may represent new cis-regulatory elements.
    [PMID: 21284757]
  6. The jasmonate-responsive activity of the jasmonate-responsive element from the ORCA3 promoter interacts in vitro and in vivo with the basic helix-loop-helix transcription factor AtMYC2.
    [PMID: 21306988]
  7. MYC3 and MYC4, act additively with MYC2 in the activation of jasmonic acid responses.
    [PMID: 21335373]
  8. demonstrated the genetic and molecular relationships of MYC2 and SPA1 in light and JA (jasmonic acid) signaling pathways. Here, we have further shown the genetic interactions between these two proteins in flowering time and lateral root development
    [PMID: 21512327]
  9. EDR1 exerts a positive and critical role in resistance responses to hemibiotrophic/necrotrophic fungi, in part by inducing antifungal protein expression through derepression of MYC2 function.
    [PMID: 21605210]
  10. MYC2-mediated repression of PLT expression is involved in jasmonate inhibition of primary root growth.
    [PMID: 21954460]
  11. MYC2 acts as a negative regulator of light induced gene expression.
    [PMID: 22424472]
  12. MYC2 interacts with RGA proteinsin regulating sesquiterpene synthase gene expression
    [PMID: 22669881]
  13. jasmonic acid predominantly promotes MYC2 protein accumulation in the morning and TIME FOR COFFEE represses accumulation of the MYC2
    [PMID: 22693280]
  14. During jasmonate signaling, MED25 physically associates with the basic helix-loop-helix transcription factor MYC2 in promoter regions of MYC2 target genes and exerts a positive effect on MYC2-regulated gene transcription.
    [PMID: 22822206]
  15. MYC2 regulates RGL3 expression through a direct association with its promotor.
    [PMID: 22892320]
  16. Together, these results reveal that phosphorylation-coupled turnover of MYC2 stimulates its transcription activity.
    [PMID: 23593022]
  17. these results provide insights into SPA1- and MYC2-mediated transcriptional regulation of the Z- and G-box containing promoters in light signaling pathways.
    [PMID: 23646119]
  18. Data indicate that JAM1 (AT2G46510) and MYC2 competitively bind to the target sequence of MYC2, which likely provides the mechanism for negative regulation of jasmonates (JAs) signaling and suppression of MYC2 functions by JAM1.
    [PMID: 23673982]
  19. MYC2 differentially regulates GATA-box conaining promoters during seedling development in Arabidopsis
    [PMID: 23857363]
  20. MYC2/MYC3/MYC4 are necessary for direct transcriptional activation of GS biosynthesis genes.
    [PMID: 23943862]
  21. MYC2 interacts with EIN3 to attenuate the transcriptional activity of EIN3 and repress ET-enhanced apical hook curvature.
    [PMID: 24399301]
  22. MYC2 physically interacts with EIN3 and inhibits its DNA binding activity
    [PMID: 24668749]
  23. AKIN10 negatively modulates AtMYC2 protein accumulation via proteasome activity upon AKIN10 kinase activity-dependent protein modification. Transgenic plants expressing AKIN10 indicates that AKIN10 activity undermined AtMYC2-dependent salt tolerance.
    [PMID: 24890857]
  24. regulator of glucosinolate biosynthesis
    [PMID: 25049362]
  25. MKK3-MPK6 is activated by blue light in a MYC2-dependent manner.
    [PMID: 25139007]
  26. A lower expression level of WRKY70 leads to significantly higher MYC2 expression through salicylic acid (SA)-jasmonic acid (JA) cross-talk.
    [PMID: 25339349]
  27. JAZ1 and JAZ10 were the only JAZ proteins still showing interaction with the mutant MYC proteins, due to a second MYC interaction domain, besides the classical Jas domain.
    [PMID: 25817565]
  28. This study reveals that MYC2 and GBF1 colocalize and physically interact in the nucleus. This interaction requires the N-terminal domain of each protein.
    [PMID: 26047210]
  29. MYC2 is targeted by PUB10 for degradation during jasmonic acid responses.
    [PMID: 26163577]
  30. Under salt stress, JA almost did not render a positive effect on the jin1 plants. It is concluded that the protein JIN1/MYC2 is involved in control of protective systems under salt stress.
    [PMID: 27266252]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00084PBM26531826Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G32640.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Detected early after abscisic acid (ABA) treatment or after dehydration and high-salt stresses. Induced by UV treatment. Up-regulated by methyl jasmonate and herbivory. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15208388, ECO:0000269|PubMed:23593022, ECO:0000269|PubMed:23943862, ECO:0000269|PubMed:9368419}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT1G32640 (R), AT4G25470 (R)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT1G17420(A), AT1G18570(R), AT1G19180(A), AT1G27730(R), AT1G28370(R), AT1G29930(A), AT1G32640(R), AT1G33760(R), AT1G67090(A), AT1G72260(R), AT1G77120(A), AT2G14610(R), AT2G24850(A), AT2G46340(A), AT3G04720(R), AT3G12500(R), AT3G15210(R), AT3G16470(A), AT3G23240(R), AT3G45140(A), AT4G17490(R), AT5G07100(R), AT5G24770(A), AT5G24780(A), AT5G25610(A), AT5G44420(R), AT5G47220(R)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDabscisic acid, jasmonic acid
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G32640, AT1G66350, AT1G74080
IntActSearch Q39204
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Minor effect on jasmonic acid response and no effect on glucosinolate biosynthesis, but decreased abscisic acid sensitivity. Myc2 and myc3 double mutant has an increased insensitivity to jasmonic acid. Myc2 and myc4 double mutant has an increased insensitivity to jasmonic acid. Myc2, myc3 and myc4 triple mutant has no jasmonate-related defense response, is devoid of glucosinolates and is extremely susceptible to generalist herbivores. {ECO:0000269|PubMed:12509522, ECO:0000269|PubMed:15208388, ECO:0000269|PubMed:21335373, ECO:0000269|PubMed:23943862}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G32640
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0171180.0AC017118.3 Genomic sequence for Arabidopsis thaliana BAC F6N18 from chromosome I, complete sequence.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
GenBankBT0030420.0BT003042.1 Arabidopsis thaliana At1g32640/F6N18_4 gene, complete cds.
GenBankAY0372030.0AY037203.1 Arabidopsis thaliana At1g32640/F6N18_4 mRNA, complete cds.
GenBankAJ8432560.0AJ843256.1 Arabidopsis thaliana mRNA for Z-box binding factor 1 protein (ZBF1 gene).
GenBankX995480.0X99548.2 Arabidopsis thaliana mRNA for bHLH protein (Rap-1 gene).
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_174541.10.0transcription factor MYC2
SwissprotQ392040.0MYC2_ARATH; Transcription factor MYC2
TrEMBLD7KHM30.0D7KHM3_ARALL; ATMYC2
STRINGAT1G32640.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP37331224
MalvidsOGEM12652896
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Gong Z, et al.
    Genes that are uniquely stress regulated in salt overly sensitive (sos) mutants.
    Plant Physiol., 2001. 126(1): p. 363-75
    [PMID:11351099]
  3. Abe H, et al.
    Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling.
    Plant Cell, 2003. 15(1): p. 63-78
    [PMID:12509522]
  4. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  5. Yamashino T, et al.
    A Link between circadian-controlled bHLH factors and the APRR1/TOC1 quintet in Arabidopsis thaliana.
    Plant Cell Physiol., 2003. 44(6): p. 619-29
    [PMID:12826627]
  6. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  7. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  8. Li L, et al.
    The tomato homolog of CORONATINE-INSENSITIVE1 is required for the maternal control of seed maturation, jasmonate-signaled defense responses, and glandular trichome development.
    Plant Cell, 2004. 16(1): p. 126-43
    [PMID:14688297]
  9. Lorenzo O,Chico JM,S
    JASMONATE-INSENSITIVE1 encodes a MYC transcription factor essential to discriminate between different jasmonate-regulated defense responses in Arabidopsis.
    Plant Cell, 2004. 16(7): p. 1938-50
    [PMID:15208388]
  10. Boter M,Ru
    Conserved MYC transcription factors play a key role in jasmonate signaling both in tomato and Arabidopsis.
    Genes Dev., 2004. 18(13): p. 1577-91
    [PMID:15231736]
  11. Anderson JP, et al.
    Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis.
    Plant Cell, 2004. 16(12): p. 3460-79
    [PMID:15548743]
  12. Yadav V,Mallappa C,Gangappa SN,Bhatia S,Chattopadhyay S
    A basic helix-loop-helix transcription factor in Arabidopsis, MYC2, acts as a repressor of blue light-mediated photomorphogenic growth.
    Plant Cell, 2005. 17(7): p. 1953-66
    [PMID:15923349]
  13. Lorenzo O,Solano R
    Molecular players regulating the jasmonate signalling network.
    Curr. Opin. Plant Biol., 2005. 8(5): p. 532-40
    [PMID:16039901]
  14. Laurie-Berry N,Joardar V,Street IH,Kunkel BN
    The Arabidopsis thaliana JASMONATE INSENSITIVE 1 gene is required for suppression of salicylic acid-dependent defenses during infection by Pseudomonas syringae.
    Mol. Plant Microbe Interact., 2006. 19(7): p. 789-800
    [PMID:16838791]
  15. Megraw M, et al.
    MicroRNA promoter element discovery in Arabidopsis.
    RNA, 2006. 12(9): p. 1612-9
    [PMID:16888323]
  16. Truman W,Bennett MH,Kubigsteltig I,Turnbull C,Grant M
    Arabidopsis systemic immunity uses conserved defense signaling pathways and is mediated by jasmonates.
    Proc. Natl. Acad. Sci. U.S.A., 2007. 104(3): p. 1075-80
    [PMID:17215350]
  17. Takahashi F, et al.
    The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis.
    Plant Cell, 2007. 19(3): p. 805-18
    [PMID:17369371]
  18. Dombrecht B, et al.
    MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis.
    Plant Cell, 2007. 19(7): p. 2225-45
    [PMID:17616737]
  19. Chini A, et al.
    The JAZ family of repressors is the missing link in jasmonate signalling.
    Nature, 2007. 448(7154): p. 666-71
    [PMID:17637675]
  20. Thines B, et al.
    JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling.
    Nature, 2007. 448(7154): p. 661-5
    [PMID:17637677]
  21. Yan Y, et al.
    A downstream mediator in the growth repression limb of the jasmonate pathway.
    Plant Cell, 2007. 19(8): p. 2470-83
    [PMID:17675405]
  22. Libault M,Wan J,Czechowski T,Udvardi M,Stacey G
    Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor.
    Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11
    [PMID:17722694]
  23. Chawade A,Br
    Putative cold acclimation pathways in Arabidopsis thaliana identified by a combined analysis of mRNA co-expression patterns, promoter motifs and transcription factors.
    BMC Genomics, 2007. 8: p. 304
    [PMID:17764576]
  24. Wang Z, et al.
    Identification and characterization of COI1-dependent transcription factor genes involved in JA-mediated response to wounding in Arabidopsis plants.
    Plant Cell Rep., 2008. 27(1): p. 125-35
    [PMID:17786451]
  25. Balbi V,Devoto A
    Jasmonate signalling network in Arabidopsis thaliana: crucial regulatory nodes and new physiological scenarios.
    New Phytol., 2008. 177(2): p. 301-18
    [PMID:18042205]
  26. Wu K,Zhang L,Zhou C,Yu CW,Chaikam V
    HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis.
    J. Exp. Bot., 2008. 59(2): p. 225-34
    [PMID:18212027]
  27. Pauwels L, et al.
    Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells.
    Proc. Natl. Acad. Sci. U.S.A., 2008. 105(4): p. 1380-5
    [PMID:18216250]
  28. Chung HS, et al.
    Regulation and function of Arabidopsis JASMONATE ZIM-domain genes in response to wounding and herbivory.
    Plant Physiol., 2008. 146(3): p. 952-64
    [PMID:18223147]
  29. Staswick PE
    JAZing up jasmonate signaling.
    Trends Plant Sci., 2008. 13(2): p. 66-71
    [PMID:18261950]
  30. Bu Q, et al.
    Role of the Arabidopsis thaliana NAC transcription factors ANAC019 and ANAC055 in regulating jasmonic acid-signaled defense responses.
    Cell Res., 2008. 18(7): p. 756-67
    [PMID:18427573]
  31. Melotto M, et al.
    A critical role of two positively charged amino acids in the Jas motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucine-dependent interactions with the COI1 F-box protein.
    Plant J., 2008. 55(6): p. 979-88
    [PMID:18547396]
  32. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  33. Pozo MJ,Van Der Ent S,Van Loon LC,Pieterse CM
    Transcription factor MYC2 is involved in priming for enhanced defense during rhizobacteria-induced systemic resistance in Arabidopsis thaliana.
    New Phytol., 2008. 180(2): p. 511-23
    [PMID:18657213]
  34. Shangguan XX,Xu B,Yu ZX,Wang LJ,Chen XY
    Promoter of a cotton fibre MYB gene functional in trichomes of Arabidopsis and glandular trichomes of tobacco.
    J. Exp. Bot., 2008. 59(13): p. 3533-42
    [PMID:18711121]
  35. Wang Y, et al.
    Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
    Plant Physiol., 2008. 148(3): p. 1201-11
    [PMID:18775970]
  36. Zhang Y,Turner JG
    Wound-induced endogenous jasmonates stunt plant growth by inhibiting mitosis.
    PLoS ONE, 2008. 3(11): p. e3699
    [PMID:19002244]
  37. Trusov Y, et al.
    Heterotrimeric G proteins-mediated resistance to necrotrophic pathogens includes mechanisms independent of salicylic acid-, jasmonic acid/ethylene- and abscisic acid-mediated defense signaling.
    Plant J., 2009. 58(1): p. 69-81
    [PMID:19054360]
  38. Clarke SM, et al.
    Jasmonates act with salicylic acid to confer basal thermotolerance in Arabidopsis thaliana.
    New Phytol., 2009. 182(1): p. 175-87
    [PMID:19140948]
  39. Chung HS,Howe GA
    A critical role for the TIFY motif in repression of jasmonate signaling by a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in Arabidopsis.
    Plant Cell, 2009. 21(1): p. 131-45
    [PMID:19151223]
  40. Jones AM, et al.
    Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana.
    J Proteomics, 2009. 72(3): p. 439-51
    [PMID:19245862]
  41. Chini A,Fonseca S,Chico JM,Fern
    The ZIM domain mediates homo- and heteromeric interactions between Arabidopsis JAZ proteins.
    Plant J., 2009. 59(1): p. 77-87
    [PMID:19309455]
  42. Okamoto H, et al.
    The alpha-subunit of the heterotrimeric G-protein affects jasmonate responses in Arabidopsis thaliana.
    J. Exp. Bot., 2009. 60(7): p. 1991-2003
    [PMID:19342430]
  43. Memelink J
    Regulation of gene expression by jasmonate hormones.
    Phytochemistry, 2009. 70(13-14): p. 1560-70
    [PMID:19796781]
  44. Zander M,La Camera S,Lamotte O,Métraux JP,Gatz C
    Arabidopsis thaliana class-II TGA transcription factors are essential activators of jasmonic acid/ethylene-induced defense responses.
    Plant J., 2010. 61(2): p. 200-10
    [PMID:19832945]
  45. Sharabi-Schwager M,Lers A,Samach A,Guy CL,Porat R
    Overexpression of the CBF2 transcriptional activator in Arabidopsis delays leaf senescence and extends plant longevity.
    J. Exp. Bot., 2010. 61(1): p. 261-73
    [PMID:19854800]
  46. Bai L,Zhou Y,Song CP
    Arabidopsis proline-rich extensin-like receptor kinase 4 modulates the early event toward abscisic acid response in root tip growth.
    Plant Signal Behav, 2009. 4(11): p. 1075-7
    [PMID:20009554]
  47. Wasternack C,Kombrink E
    Jasmonates: structural requirements for lipid-derived signals active in plant stress responses and development.
    ACS Chem. Biol., 2010. 5(1): p. 63-77
    [PMID:20025249]
  48. Pauwels L,Goossens A
    Fine-tuning of early events in the jasmonate response.
    Plant Signal Behav, 2008. 3(10): p. 846-7
    [PMID:20140232]
  49. Millet YA, et al.
    Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns.
    Plant Cell, 2010. 22(3): p. 973-90
    [PMID:20348432]
  50. Lee JH, et al.
    DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction.
    Plant Cell, 2010. 22(6): p. 1716-32
    [PMID:20525848]
  51. Sehr EM, et al.
    Analysis of secondary growth in the Arabidopsis shoot reveals a positive role of jasmonate signalling in cambium formation.
    Plant J., 2010. 63(5): p. 811-22
    [PMID:20579310]
  52. Geerinck J,Pauwels L,De Jaeger G,Goossens A
    Dissection of the one-MegaDalton JAZ1 protein complex.
    Plant Signal Behav, 2010. 5(8): p. 1039-41
    [PMID:20671423]
  53. Hanada K, et al.
    Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana.
    Mol. Biol. Evol., 2011. 28(1): p. 377-82
    [PMID:20736450]
  54. Elrouby N,Coupland G
    Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes.
    Proc. Natl. Acad. Sci. U.S.A., 2010. 107(40): p. 17415-20
    [PMID:20855607]
  55. Gangappa SN,Prasad VB,Chattopadhyay S
    Functional interconnection of MYC2 and SPA1 in the photomorphogenic seedling development of Arabidopsis.
    Plant Physiol., 2010. 154(3): p. 1210-9
    [PMID:20864543]
  56. Hou X,Lee LY,Xia K,Yan Y,Yu H
    DELLAs modulate jasmonate signaling via competitive binding to JAZs.
    Dev. Cell, 2010. 19(6): p. 884-94
    [PMID:21145503]
  57. Cheng Z, et al.
    The bHLH transcription factor MYC3 interacts with the Jasmonate ZIM-domain proteins to mediate jasmonate response in Arabidopsis.
    Mol Plant, 2011. 4(2): p. 279-88
    [PMID:21242320]
  58. Godoy M, et al.
    Improved protein-binding microarrays for the identification of DNA-binding specificities of transcription factors.
    Plant J., 2011. 66(4): p. 700-11
    [PMID:21284757]
  59. Montiel G,Zarei A,K
    The jasmonate-responsive element from the ORCA3 promoter from Catharanthus roseus is active in Arabidopsis and is controlled by the transcription factor AtMYC2.
    Plant Cell Physiol., 2011. 52(3): p. 578-87
    [PMID:21306988]
  60. Niu Y,Figueroa P,Browse J
    Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis.
    J. Exp. Bot., 2011. 62(6): p. 2143-54
    [PMID:21321051]
  61. Fern
    The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses.
    Plant Cell, 2011. 23(2): p. 701-15
    [PMID:21335373]
  62. Lee JH,Terzaghi W,Deng XW
    DWA3, an Arabidopsis DWD protein, acts as a negative regulator in ABA signal transduction.
    Plant Sci., 2011. 180(2): p. 352-7
    [PMID:21421380]
  63. Maruta T, et al.
    Arabidopsis NADPH oxidases, AtrbohD and AtrbohF, are essential for jasmonic acid-induced expression of genes regulated by MYC2 transcription factor.
    Plant Sci., 2011. 180(4): p. 655-60
    [PMID:21421415]
  64. Zhao Y,Zhou LM,Chen YY,Yang SG,Tian WM
    MYC genes with differential responses to tapping, mechanical wounding, ethrel and methyl jasmonate in laticifers of rubber tree (Hevea brasiliensis Muell. Arg.).
    J. Plant Physiol., 2011. 168(14): p. 1649-58
    [PMID:21489651]
  65. Gangappa SN,Chattopadhyay S
    MYC2, a bHLH transcription factor, modulates the adult phenotype of SPA1.
    Plant Signal Behav, 2010. 5(12): p. 1650-2
    [PMID:21512327]
  66. Shoji T,Hashimoto T
    Tobacco MYC2 regulates jasmonate-inducible nicotine biosynthesis genes directly and by way of the NIC2-locus ERF genes.
    Plant Cell Physiol., 2011. 52(6): p. 1117-30
    [PMID:21576194]
  67. Hiruma K, et al.
    Arabidopsis ENHANCED DISEASE RESISTANCE 1 is required for pathogen-induced expression of plant defensins in nonhost resistance, and acts through interference of MYC2-mediated repressor function.
    Plant J., 2011. 67(6): p. 980-92
    [PMID:21605210]
  68. Demianski AJ,Chung KM,Kunkel BN
    Analysis of Arabidopsis JAZ gene expression during Pseudomonas syringae pathogenesis.
    Mol. Plant Pathol., 2012. 13(1): p. 46-57
    [PMID:21726394]
  69. Costigan SE,Warnasooriya SN,Humphries BA,Montgomery BL
    Root-localized phytochrome chromophore synthesis is required for photoregulation of root elongation and impacts root sensitivity to jasmonic acid in Arabidopsis.
    Plant Physiol., 2011. 157(3): p. 1138-50
    [PMID:21875894]
  70. Tominaga-Wada R,Iwata M,Nukumizu Y,Wada T
    Analysis of IIId, IIIe and IVa group basic-helix-loop-helix proteins expressed in Arabidopsis root epidermis.
    Plant Sci., 2011. 181(4): p. 471-8
    [PMID:21889054]
  71. Klopffleisch K, et al.
    Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis.
    Mol. Syst. Biol., 2011. 7: p. 532
    [PMID:21952135]
  72. Chen Q, et al.
    The basic helix-loop-helix transcription factor MYC2 directly represses PLETHORA expression during jasmonate-mediated modulation of the root stem cell niche in Arabidopsis.
    Plant Cell, 2011. 23(9): p. 3335-52
    [PMID:21954460]
  73. Hiruma K,Takano Y
    Roles of EDR1 in non-host resistance of Arabidopsis.
    Plant Signal Behav, 2011. 6(11): p. 1831-3
    [PMID:22057322]
  74. Figueroa P,Browse J
    The Arabidopsis JAZ2 promoter contains a G-Box and thymidine-rich module that are necessary and sufficient for jasmonate-dependent activation by MYC transcription factors and repression by JAZ proteins.
    Plant Cell Physiol., 2012. 53(2): p. 330-43
    [PMID:22173100]
  75. Prasad BR,Kumar SV,Nandi A,Chattopadhyay S
    Functional interconnections of HY1 with MYC2 and HY5 in Arabidopsis seedling development.
    BMC Plant Biol., 2012. 12: p. 37
    [PMID:22424472]
  76. K
    Xenobiotic- and jasmonic acid-inducible signal transduction pathways have become interdependent at the Arabidopsis CYP81D11 promoter.
    Plant Physiol., 2012. 159(1): p. 391-402
    [PMID:22452854]
  77. Verhage A, et al.
    Rewiring of the Jasmonate Signaling Pathway in Arabidopsis during Insect Herbivory.
    Front Plant Sci, 2011. 2: p. 47
    [PMID:22645537]
  78. Hong GJ,Xue XY,Mao YB,Wang LJ,Chen XY
    Arabidopsis MYC2 interacts with DELLA proteins in regulating sesquiterpene synthase gene expression.
    Plant Cell, 2012. 24(6): p. 2635-48
    [PMID:22669881]
  79. Shin J,Heidrich K,Sanchez-Villarreal A,Parker JE,Davis SJ
    TIME FOR COFFEE represses accumulation of the MYC2 transcription factor to provide time-of-day regulation of jasmonate signaling in Arabidopsis.
    Plant Cell, 2012. 24(6): p. 2470-82
    [PMID:22693280]
  80. Chen R, et al.
    The Arabidopsis mediator subunit MED25 differentially regulates jasmonate and abscisic acid signaling through interacting with the MYC2 and ABI5 transcription factors.
    Plant Cell, 2012. 24(7): p. 2898-916
    [PMID:22822206]

  81. MEDIATOR25 acts as an integrative hub for the regulation of jasmonate-responsive gene expression in Arabidopsis.
    Plant Physiol., 2012. 160(1): p. 541-55
    [PMID:22822211]
  82. Wild M, et al.
    The Arabidopsis DELLA RGA-LIKE3 is a direct target of MYC2 and modulates jasmonate signaling responses.
    Plant Cell, 2012. 24(8): p. 3307-19
    [PMID:22892320]
  83. Lakshmanan V, et al.
    Microbe-associated molecular patterns-triggered root responses mediate beneficial rhizobacterial recruitment in Arabidopsis.
    Plant Physiol., 2012. 160(3): p. 1642-61
    [PMID:22972705]
  84. Meinke DW
    A survey of dominant mutations in Arabidopsis thaliana.
    Trends Plant Sci., 2013. 18(2): p. 84-91
    [PMID:22995285]
  85. Guo J, et al.
    Proteomic identification of MYC2-dependent jasmonate-regulated proteins in Arabidopsis thaliana.
    Proteome Sci, 2012. 10(1): p. 57
    [PMID:23009548]
  86. Kazan K,Manners JM
    MYC2: the master in action.
    Mol Plant, 2013. 6(3): p. 686-703
    [PMID:23142764]
  87. Withers J, et al.
    Transcription factor-dependent nuclear localization of a transcriptional repressor in jasmonate hormone signaling.
    Proc. Natl. Acad. Sci. U.S.A., 2012. 109(49): p. 20148-53
    [PMID:23169619]
  88. Kim B,Fujioka S,Kwon M,Jeon J,Choe S
    Arabidopsis brassinosteroid-overproducing gulliver3-D/dwarf4-D mutants exhibit altered responses to jasmonic acid and pathogen.
    Plant Cell Rep., 2013. 32(7): p. 1139-49
    [PMID:23297052]
  89. Schweizer F,Bodenhausen N,Lassueur S,Masclaux FG,Reymond P
    Differential Contribution of Transcription Factors to Arabidopsis thaliana Defense Against Spodoptera littoralis.
    Front Plant Sci, 2013. 4: p. 13
    [PMID:23382734]
  90. Kundu N,Dozier U,Deslandes L,Somssich IE,Ullah H
    Arabidopsis scaffold protein RACK1A interacts with diverse environmental stress and photosynthesis related proteins.
    Plant Signal Behav, 2013. 8(5): p. e24012
    [PMID:23435172]
  91. Du ZY,Chen MX,Chen QF,Xiao S,Chye ML
    Arabidopsis acyl-CoA-binding protein ACBP1 participates in the regulation of seed germination and seedling development.
    Plant J., 2013. 74(2): p. 294-309
    [PMID:23448237]
  92. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  93. Elhiti M, et al.
    Function of type-2 Arabidopsis hemoglobin in the auxin-mediated formation of embryogenic cells during morphogenesis.
    Plant J., 2013. 74(6): p. 946-58
    [PMID:23510449]
  94. Zhai Q, et al.
    Phosphorylation-coupled proteolysis of the transcription factor MYC2 is important for jasmonate-signaled plant immunity.
    PLoS Genet., 2013. 9(4): p. e1003422
    [PMID:23593022]
  95. Scala A, et al.
    E-2-hexenal promotes susceptibility to Pseudomonas syringae by activating jasmonic acid pathways in Arabidopsis.
    Front Plant Sci, 2013. 4: p. 74
    [PMID:23630530]
  96. Moreno JE, et al.
    Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10.
    Plant Physiol., 2013. 162(2): p. 1006-17
    [PMID:23632853]
  97. Gangappa SN,Maurya JP,Yadav V,Chattopadhyay S
    The regulation of the Z- and G-box containing promoters by light signaling components, SPA1 and MYC2, in Arabidopsis.
    PLoS ONE, 2013. 8(4): p. e62194
    [PMID:23646119]
  98. Nakata M, et al.
    A bHLH-type transcription factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, acts as a repressor to negatively regulate jasmonate signaling in arabidopsis.
    Plant Cell, 2013. 25(5): p. 1641-56
    [PMID:23673982]
  99. Gangappa SN,Chattopadhyay S
    MYC2 differentially regulates GATA-box containing promoters during seedling development in Arabidopsis.
    Plant Signal Behav, 2013. 8(10): p. doi: 10.4161/psb.25679
    [PMID:23857363]
  100. Schweizer F, et al.
    Arabidopsis basic helix-loop-helix transcription factors MYC2, MYC3, and MYC4 regulate glucosinolate biosynthesis, insect performance, and feeding behavior.
    Plant Cell, 2013. 25(8): p. 3117-32
    [PMID:23943862]
  101. Song S, et al.
    Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis.
    Plant Cell, 2014. 26(1): p. 263-79
    [PMID:24399301]
  102. Zhang X, et al.
    Jasmonate-activated MYC2 represses ETHYLENE INSENSITIVE3 activity to antagonize ethylene-promoted apical hook formation in Arabidopsis.
    Plant Cell, 2014. 26(3): p. 1105-17
    [PMID:24668749]
  103. Im JH, et al.
    Inverse modulation of the energy sensor Snf1-related protein kinase 1 on hypoxia adaptation and salt stress tolerance in Arabidopsis thaliana.
    Plant Cell Environ., 2014. 37(10): p. 2303-12
    [PMID:24890857]
  104. Frerigmann H,Berger B,Gigolashvili T
    bHLH05 is an interaction partner of MYB51 and a novel regulator of glucosinolate biosynthesis in Arabidopsis.
    Plant Physiol., 2014. 166(1): p. 349-69
    [PMID:25049362]
  105. Sethi V,Raghuram B,Sinha AK,Chattopadhyay S
    A mitogen-activated protein kinase cascade module, MKK3-MPK6 and MYC2, is involved in blue light-mediated seedling development in Arabidopsis.
    Plant Cell, 2014. 26(8): p. 3343-57
    [PMID:25139007]
  106. Kroes A,van Loon JJ,Dicke M
    Density-dependent interference of aphids with caterpillar-induced defenses in Arabidopsis: involvement of phytohormones and transcription factors.
    Plant Cell Physiol., 2015. 56(1): p. 98-106
    [PMID:25339349]
  107. Li R, et al.
    Virulence factors of geminivirus interact with MYC2 to subvert plant resistance and promote vector performance.
    Plant Cell, 2014. 26(12): p. 4991-5008
    [PMID:25490915]
  108. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]
  109. Goossens J,Swinnen G,Vanden Bossche R,Pauwels L,Goossens A
    Change of a conserved amino acid in the MYC2 and MYC3 transcription factors leads to release of JAZ repression and increased activity.
    New Phytol., 2015. 206(4): p. 1229-37
    [PMID:25817565]
  110. Thireault C, et al.
    Repression of jasmonate signaling by a non-TIFY JAZ protein in Arabidopsis.
    Plant J., 2015. 82(4): p. 669-79
    [PMID:25846245]
  111. Qi T,Huang H,Song S,Xie D
    Regulation of Jasmonate-Mediated Stamen Development and Seed Production by a bHLH-MYB Complex in Arabidopsis.
    Plant Cell, 2015. 27(6): p. 1620-33
    [PMID:26002869]
  112. Maurya JP,Sethi V,Gangappa SN,Gupta N,Chattopadhyay S
    Interaction of MYC2 and GBF1 results in functional antagonism in blue light-mediated Arabidopsis seedling development.
    Plant J., 2015. 83(3): p. 439-50
    [PMID:26047210]
  113. Jung C, et al.
    PLANT U-BOX PROTEIN10 Regulates MYC2 Stability in Arabidopsis.
    Plant Cell, 2015. 27(7): p. 2016-31
    [PMID:26163577]
  114. Pauwels L, et al.
    The RING E3 Ligase KEEP ON GOING Modulates JASMONATE ZIM-DOMAIN12 Stability.
    Plant Physiol., 2015. 169(2): p. 1405-17
    [PMID:26320228]
  115. Yastreb TO,Kolupaev YE,Lugovaya AA,Dmitriev AP
    [Content of Osmolytes and Flavonoids under Salt Stress in Arabidopsis thaliana Plants Defective in Jasmonate Signaling].
    Prikl. Biokhim. Mikrobiol., 2016 Mar-Apr. 52(2): p. 223-9
    [PMID:27266252]
  116. de Pater S,Pham K,Memelink J,Kijne J
    RAP-1 is an Arabidopsis MYC-like R protein homologue, that binds to G-box sequence motifs.
    Plant Mol. Biol., 1997. 34(1): p. 169-74
    [PMID:9177323]
  117. Abe H, et al.
    Role of arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression.
    Plant Cell, 1997. 9(10): p. 1859-68
    [PMID:9368419]
  118. Rojo E, et al.
    Reversible protein phosphorylation regulates jasmonic acid-dependent and -independent wound signal transduction pathways in Arabidopsis thaliana.
    Plant J., 1998. 13(2): p. 153-65
    [PMID:9680973]