PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G28360.1
Common NameATERF12, ERF081, ERF12, ERF-12, F3M18.21
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 189aa    MW: 20946.6 Da    PI: 9.9131
Description ERF domain protein 12
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G28360.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP262.31.1e-191160255
          AP2  2 gykGVrwdkkrgrWvAeIrd.psengkrkrfslgkfgtaeeAakaaiaarkkleg 55
                 +y+GVr ++ +gr++AeIrd ++    ++r++lg+f+t+eeAa a++ a++ l+g
  AT1G28360.1 11 HYRGVRKRP-WGRYAAEIRDpWK----KTRVWLGTFDTPEEAALAYDGAARFLRG 60
                 6********.**********883....5***********************9997 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.730.103.7E-311168IPR001471AP2/ERF domain
SuperFamilySSF541714.97E-221169IPR016177DNA-binding domain
SMARTSM003803.0E-341174IPR001471AP2/ERF domain
CDDcd000189.38E-301168No hitNo description
PROSITE profilePS5103222.4051168IPR001471AP2/ERF domain
PfamPF008473.3E-131160IPR001471AP2/ERF domain
PRINTSPR003675.7E-111223IPR001471AP2/ERF domain
PRINTSPR003675.7E-113450IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0006952Biological Processdefense response
GO:0009873Biological Processethylene-activated signaling pathway
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000293anatomyguard cell
PO:0009005anatomyroot
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009031anatomysepal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0025022anatomycollective leaf structure
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007611developmental stagepetal differentiation and expansion stage
Sequence ? help Back to Top
Protein Sequence    Length: 189 aa     Download sequence    Send to blast
MASTTCAREV HYRGVRKRPW GRYAAEIRDP WKKTRVWLGT FDTPEEAALA YDGAARFLRG  60
IKAKTNFPSP LSLDLNHLPS APSAATAAAN NQPHQHQQLW FAAPPPVPPS SDHHHQHHRI  120
FLRTGVLNDK TSDYSSTEAP LYFTSSPNTA TSSPGYQVVG FPMMNSSPSP VTVRRGLAID  180
LNEPPPLWL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2gcc_A7e-21768163ATERF1
3gcc_A7e-21768163ATERF1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.409060.0flower| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible261496_at0.0
Expression AtlasAT1G28360-
AtGenExpressAT1G28360-
ATTED-IIAT1G28360-
Functional Description ? help Back to Top
Source Description
TAIRencodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family (ERF12). The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole.
UniProtInvolved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity). {ECO:0000250, ECO:0000269|PubMed:11487705}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00645PBMTransfer from LOC_Os05g41760Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G28360.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDethylene
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G32540, AT1G69690
IntActSearch Q94ID6
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G28360
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0558830.0AB055883.1 Arabidopsis thaliana AtERF12 gene for ERF domain protein12, complete cds.
GenBankAC0101550.0AC010155.3 Genomic sequence for Arabidopsis thaliana BAC F3M18 from chromosome I, complete sequence.
GenBankAY0997980.0AY099798.1 Arabidopsis thaliana ethylene responsive element binding factor, putative (At1g28360) mRNA, complete cds.
GenBankBT0026040.0BT002604.1 Arabidopsis thaliana ethylene responsive element binding factor, putative (At1g28360) mRNA, complete cds.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_174158.11e-138ERF domain protein 12
SwissprotQ94ID61e-139ERF81_ARATH; Ethylene-responsive transcription factor 12
TrEMBLA0A178WCW01e-137A0A178WCW0_ARATH; ERF12
STRINGAT1G28360.11e-138(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM10281650
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Ohta M,Matsui K,Hiratsu K,Shinshi H,Ohme-Takagi M
    Repression domains of class II ERF transcriptional repressors share an essential motif for active repression.
    Plant Cell, 2001. 13(8): p. 1959-68
    [PMID:11487705]
  3. O
    Identification of Arabidopsis ethylene-responsive element binding factors with distinct induction kinetics after pathogen infection.
    Plant Physiol., 2002. 128(4): p. 1313-22
    [PMID:11950980]
  4. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  5. Cluis CP,Mouchel CF,Hardtke CS
    The Arabidopsis transcription factor HY5 integrates light and hormone signaling pathways.
    Plant J., 2004. 38(2): p. 332-47
    [PMID:15078335]
  6. Vergnolle C, et al.
    The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions.
    Plant Physiol., 2005. 139(3): p. 1217-33
    [PMID:16258011]
  7. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
    [PMID:16407444]
  8. Cao D,Cheng H,Wu W,Soo HM,Peng J
    Gibberellin mobilizes distinct DELLA-dependent transcriptomes to regulate seed germination and floral development in Arabidopsis.
    Plant Physiol., 2006. 142(2): p. 509-25
    [PMID:16920880]
  9. Ikeda Y,Banno H,Niu QW,Howell SH,Chua NH
    The ENHANCER OF SHOOT REGENERATION 2 gene in Arabidopsis regulates CUP-SHAPED COTYLEDON 1 at the transcriptional level and controls cotyledon development.
    Plant Cell Physiol., 2006. 47(11): p. 1443-56
    [PMID:17056621]
  10. Stracke R, et al.
    Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling.
    Plant J., 2007. 50(4): p. 660-77
    [PMID:17419845]
  11. Song YH, et al.
    DNA-binding study identifies C-box and hybrid C/G-box or C/A-box motifs as high-affinity binding sites for STF1 and LONG HYPOCOTYL5 proteins.
    Plant Physiol., 2008. 146(4): p. 1862-77
    [PMID:18287490]
  12. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  13. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  14. Causier B,Ashworth M,Guo W,Davies B
    The TOPLESS interactome: a framework for gene repression in Arabidopsis.
    Plant Physiol., 2012. 158(1): p. 423-38
    [PMID:22065421]
  15. Riechmann JL,Meyerowitz EM
    The AP2/EREBP family of plant transcription factors.
    Biol. Chem., 1998. 379(6): p. 633-46
    [PMID:9687012]