PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G27730.1
Common NameSTZ, T22C5.18, ZAT10
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 227aa    MW: 24614.5 Da    PI: 8.3939
Description salt tolerance zinc finger
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G27730.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H215.26.1e-0580102123
                  EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                  ykC+ C+k+Fs+   L  H  +H
  AT1G27730.1  80 YKCSVCDKTFSSYQALGGHKASH 102
                  9***********99999998887 PP

2zf-C2H2110.0013136155120
                  EEETTTTEEESSHHHHHHHH CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHi 20 
                  ++C++C+ksF++   L  H 
  AT1G27730.1 136 HVCTICNKSFPSGQALGGHK 155
                  79*********988776665 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.605.9E-480102IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.00380102IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.20180107IPR007087Zinc finger, C2H2
SuperFamilySSF576671.24E-980102No hitNo description
PfamPF139121.1E-1380104IPR007087Zinc finger, C2H2
PROSITE patternPS00028082102IPR007087Zinc finger, C2H2
SuperFamilySSF576671.24E-9131158No hitNo description
SMARTSM003550.036136158IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.411136163IPR007087Zinc finger, C2H2
PfamPF139121.6E-13136160IPR007087Zinc finger, C2H2
PROSITE patternPS000280138158IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006979Biological Processresponse to oxidative stress
GO:0009409Biological Processresponse to cold
GO:0009414Biological Processresponse to water deprivation
GO:0009611Biological Processresponse to wounding
GO:0009644Biological Processresponse to high light intensity
GO:0009651Biological Processresponse to salt stress
GO:0009737Biological Processresponse to abscisic acid
GO:0010117Biological Processphotoprotection
GO:0010200Biological Processresponse to chitin
GO:0015979Biological Processphotosynthesis
GO:0035264Biological Processmulticellular organism growth
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000034anatomyvascular system
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 227 aa     Download sequence    Send to blast
MALEALTSPR LASPIPPLFE DSSVFHGVEH WTKGKRSKRS RSDFHHQNLT EEEYLAFCLM  60
LLARDNRQPP PPPAVEKLSY KCSVCDKTFS SYQALGGHKA SHRKNLSQTL SGGGDDHSTS  120
SATTTSAVTT GSGKSHVCTI CNKSFPSGQA LGGHKRCHYE GNNNINTSSV SNSEGAGSTS  180
HVSSSHRGFD LNIPPIPEFS MVNGDDEVMS PMPAKKPRFD FPVKLQL
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.246240.0leaf| root| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO15652260.0
Genevisible261648_at0.0
Expression AtlasAT1G27730-
AtGenExpressAT1G27730-
ATTED-IIAT1G27730-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots, stems and leaves. {ECO:0000269|PubMed:10806347, ECO:0000269|PubMed:15333755, ECO:0000269|PubMed:8662738, ECO:0000269|PubMed:9132053}.
Functional Description ? help Back to Top
Source Description
TAIRRelated to Cys2/His2-type zinc-finger proteins found in higher plants. Compensated for a subset of calcineurin deficiency in yeast. Salt tolerance produced by ZAT10 appeared to be partially dependent on ENA1/PMR2, a P-type ATPase required for Li+ and Na+ efflux in yeast. The protein is localized to the nucleus, acts as a transcriptional repressor and is responsive to chitin oligomers. Also involved in response to photooxidative stress.
UniProtTranscriptional repressor involved in abiotic stress responses. Can repress the stress responsive genes DREB1A and LTI78. Probably involved in jasmonate (JA) early signaling response. May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade. {ECO:0000269|PubMed:12032082, ECO:0000269|PubMed:15333755, ECO:0000269|PubMed:17112521, ECO:0000269|PubMed:18216250, ECO:0000269|PubMed:20140232, ECO:0000269|PubMed:8662738}.
Function -- GeneRIF ? help Back to Top
  1. Zat10 plays a key role as both a positive and a negative regulator of plant defenses.
    [PMID: 17112521]
  2. Data show thatZAT10 overexpression resulted in enhanced tolerance to photoinhibitory light and exogenous H2O2, increased expression of antioxidative genes whose products are targeted to multiple subcellular compartments.
    [PMID: 18156220]
  3. a C(2)H(2)-type zinc finger transcription factor from Arabidopsis, ZAT10, is a substrate of Mitogen-activated protein kinases.
    [PMID: 22134874]
  4. Overall, our findings indicate that H(2) acts as a novel and cytoprotective regulator in coupling ZAT10/12-mediated antioxidant defence and maintenance of ion homeostasis in the improvement of Arabidopsis salt tolerance
    [PMID: 23185443]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00162DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G27730.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By salt, cold and drought stresses. Down-regulated by gibberellin. {ECO:0000269|PubMed:10806347, ECO:0000269|PubMed:11351099, ECO:0000269|PubMed:12837949, ECO:0000269|PubMed:15333755, ECO:0000269|PubMed:17112521, ECO:0000269|PubMed:8662738}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT1G32640 (R)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT1G07890(A), AT1G17420(R), AT1G19180(R), AT3G09640(A), AT4G25100(A), AT5G52310(R)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDabscisic acid
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G27730
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF2503360.0AF250336.1 Arabidopsis thaliana zinc finger protein STZ/ZAT10 (STZ/ZAT10) mRNA, complete cds.
GenBankAC0123750.0AC012375.3 Genomic sequence for Arabidopsis thaliana BAC T22C5 from chromosome I, complete sequence.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
GenBankAY0630060.0AY063006.1 Arabidopsis thaliana putative salt-tolerance zinc finger protein (At1g27730) mRNA, complete cds.
GenBankAY0349980.0AY034998.1 Arabidopsis thaliana putative salt-tolerance zinc finger protein (At1g27730) mRNA, complete cds.
GenBankX955730.0X95573.1 A.thaliana mRNA for salt-tolerance zinc finger protein.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_174094.11e-170zinc finger protein STZ/ZAT10
SwissprotQ962891e-172ZAT10_ARATH; Zinc finger protein ZAT10
TrEMBLD7KBU21e-139D7KBU2_ARALL; Putative uncharacterized protein
STRINGAT1G27730.11e-169(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP13115149
MalvidsOGEM12112898
Publications ? help Back to Top
  1. Takatsuji H
    Zinc-finger proteins: the classical zinc finger emerges in contemporary plant science.
    Plant Mol. Biol., 1999. 39(6): p. 1073-8
    [PMID:10380795]
  2. Sakamoto H,Araki T,Meshi T,Iwabuchi M
    Expression of a subset of the Arabidopsis Cys(2)/His(2)-type zinc-finger protein gene family under water stress.
    Gene, 2000. 248(1-2): p. 23-32
    [PMID:10806347]
  3. Kleinow T, et al.
    Functional identification of an Arabidopsis snf4 ortholog by screening for heterologous multicopy suppressors of snf4 deficiency in yeast.
    Plant J., 2000. 23(1): p. 115-22
    [PMID:10929106]
  4. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  5. Gong Z, et al.
    Genes that are uniquely stress regulated in salt overly sensitive (sos) mutants.
    Plant Physiol., 2001. 126(1): p. 363-75
    [PMID:11351099]
  6. Lee H, et al.
    LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase.
    EMBO J., 2002. 21(11): p. 2692-702
    [PMID:12032082]
  7. Ogawa M, et al.
    Gibberellin biosynthesis and response during Arabidopsis seed germination.
    Plant Cell, 2003. 15(7): p. 1591-604
    [PMID:12837949]
  8. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  9. Sakamoto H, et al.
    Arabidopsis Cys2/His2-type zinc-finger proteins function as transcription repressors under drought, cold, and high-salinity stress conditions.
    Plant Physiol., 2004. 136(1): p. 2734-46
    [PMID:15333755]
  10. Ramonell K, et al.
    Loss-of-function mutations in chitin responsive genes show increased susceptibility to the powdery mildew pathogen Erysiphe cichoracearum.
    Plant Physiol., 2005. 138(2): p. 1027-36
    [PMID:15923325]
  11. Taki N, et al.
    12-oxo-phytodienoic acid triggers expression of a distinct set of genes and plays a role in wound-induced gene expression in Arabidopsis.
    Plant Physiol., 2005. 139(3): p. 1268-83
    [PMID:16258017]
  12. Mitsuya Y, et al.
    Identification of a novel Cys2/His2-type zinc-finger protein as a component of a spermine-signaling pathway in tobacco.
    J. Plant Physiol., 2007. 164(6): p. 785-93
    [PMID:16882456]
  13. Mittler R, et al.
    Gain- and loss-of-function mutations in Zat10 enhance the tolerance of plants to abiotic stress.
    FEBS Lett., 2006. 580(28-29): p. 6537-42
    [PMID:17112521]
  14. Panadero J,Hern
    Overexpression of the calcineurin target CRZ1 provides freeze tolerance and enhances the fermentative capacity of baker's yeast.
    Appl. Environ. Microbiol., 2007. 73(15): p. 4824-31
    [PMID:17557846]
  15. Rossel JB, et al.
    Systemic and intracellular responses to photooxidative stress in Arabidopsis.
    Plant Cell, 2007. 19(12): p. 4091-110
    [PMID:18156220]
  16. Pauwels L, et al.
    Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells.
    Proc. Natl. Acad. Sci. U.S.A., 2008. 105(4): p. 1380-5
    [PMID:18216250]
  17. Zhou QY, et al.
    Soybean WRKY-type transcription factor genes, GmWRKY13, GmWRKY21, and GmWRKY54, confer differential tolerance to abiotic stresses in transgenic Arabidopsis plants.
    Plant Biotechnol. J., 2008. 6(5): p. 486-503
    [PMID:18384508]
  18. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  19. Wilson PB, et al.
    The nucleotidase/phosphatase SAL1 is a negative regulator of drought tolerance in Arabidopsis.
    Plant J., 2009. 58(2): p. 299-317
    [PMID:19170934]
  20. Zhou X,Hua D,Chen Z,Zhou Z,Gong Z
    Elongator mediates ABA responses, oxidative stress resistance and anthocyanin biosynthesis in Arabidopsis.
    Plant J., 2009. 60(1): p. 79-90
    [PMID:19500300]
  21. Bai L,Zhou Y,Song CP
    Arabidopsis proline-rich extensin-like receptor kinase 4 modulates the early event toward abscisic acid response in root tip growth.
    Plant Signal Behav, 2009. 4(11): p. 1075-7
    [PMID:20009554]
  22. Pauwels L,Goossens A
    Fine-tuning of early events in the jasmonate response.
    Plant Signal Behav, 2008. 3(10): p. 846-7
    [PMID:20140232]
  23. Tseng CC, et al.
    Editing of accD and ndhF chloroplast transcripts is partially affected in the Arabidopsis vanilla cream1 mutant.
    Plant Mol. Biol., 2010. 73(3): p. 309-23
    [PMID:20143129]
  24. Causier B,Ashworth M,Guo W,Davies B
    The TOPLESS interactome: a framework for gene repression in Arabidopsis.
    Plant Physiol., 2012. 158(1): p. 423-38
    [PMID:22065421]
  25. Nguyen XC, et al.
    Identification of a C2H2-type zinc finger transcription factor (ZAT10) from Arabidopsis as a substrate of MAP kinase.
    Plant Cell Rep., 2012. 31(4): p. 737-45
    [PMID:22134874]
  26. Niu CF, et al.
    Wheat WRKY genes TaWRKY2 and TaWRKY19 regulate abiotic stress tolerance in transgenic Arabidopsis plants.
    Plant Cell Environ., 2012. 35(6): p. 1156-70
    [PMID:22220579]
  27. Mehterov N, et al.
    Oxidative stress provokes distinct transcriptional responses in the stress-tolerant atr7 and stress-sensitive loh2 Arabidopsis thaliana mutants as revealed by multi-parallel quantitative real-time PCR analysis of ROS marker and antioxidant genes.
    Plant Physiol. Biochem., 2012. 59: p. 20-9
    [PMID:22710144]
  28. Xie Y,Mao Y,Lai D,Zhang W,Shen W
    H(2) enhances arabidopsis salt tolerance by manipulating ZAT10/12-mediated antioxidant defence and controlling sodium exclusion.
    PLoS ONE, 2012. 7(11): p. e49800
    [PMID:23185443]
  29. Dubois M, et al.
    Ethylene Response Factor6 acts as a central regulator of leaf growth under water-limiting conditions in Arabidopsis.
    Plant Physiol., 2013. 162(1): p. 319-32
    [PMID:23553636]
  30. Hahn A, et al.
    Plant core environmental stress response genes are systemically coordinated during abiotic stresses.
    Int J Mol Sci, 2013. 14(4): p. 7617-41
    [PMID:23567274]
  31. Xie Y, et al.
    Roles of NIA/NR/NOA1-dependent nitric oxide production and HY1 expression in the modulation of Arabidopsis salt tolerance.
    J. Exp. Bot., 2013. 64(10): p. 3045-60
    [PMID:23744476]
  32. Zhan GM, et al.
    Cosuppression of RBCS3B in Arabidopsis leads to severe photoinhibition caused by ROS accumulation.
    Plant Cell Rep., 2014. 33(7): p. 1091-108
    [PMID:24682522]
  33. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]
  34. Lippuner V,Cyert MS,Gasser CS
    Two classes of plant cDNA clones differentially complement yeast calcineurin mutants and increase salt tolerance of wild-type yeast.
    J. Biol. Chem., 1996. 271(22): p. 12859-66
    [PMID:8662738]
  35. Meissner R,Michael AJ
    Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc finger protein genes and cDNAs.
    Plant Mol. Biol., 1997. 33(4): p. 615-24
    [PMID:9132053]