PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G26260.3
Common NameBHLH76, CIB5, EN83, F28B23.8
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 339aa    MW: 37641.9 Da    PI: 5.7628
Description cryptochrome-interacting basic-helix-loop-helix 5
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G26260.3genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH283.9e-09181229355
                  HHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   3 rahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                   +h+ +Er RR++i +++  L++l+P +    +k   Ka +L + ++Y++sLq
  AT1G26260.3 181 NSHSLAERVRREKISERMKFLQDLVPGC----DKVTGKAVMLDEIINYVQSLQ 229
                  58*************************9....555*****************9 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.29E-10176233No hitNo description
SuperFamilySSF474591.44E-16176246IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.497178228IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.107.5E-16179242IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.7E-6181229IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003539.8E-9184234IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009637Biological Processresponse to blue light
GO:0009911Biological Processpositive regulation of flower development
GO:0040008Biological Processregulation of growth
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 339 aa     Download sequence    Send to blast
MSDKDEFAAK KKDLVNTPVD LYPPENPMLG PSPMMDSFRE TLWHDGGFNV HTDADTSFRD  60
STGLFLQDTQ IPSGSKLDNG PLTDASKLVK ERSINNVSED SQSSGGNGHD DAKCGQTSSK  120
GFSSKKRKRI GKDCEEEEDK KQKDEQSPTS NANKTNSEKQ PSDSLKDGYI HMRARRGQAT  180
NSHSLAERVR REKISERMKF LQDLVPGCDK VTGKAVMLDE IINYVQSLQC QIEFLSMKLS  240
AVNPVLDFNL ESLLAKDALQ SSAPTFPHNM SMLYPPVSYL SQTGFMQPNI SSMSLLSGGL  300
KRQETHGYES DHHNLVHMNH ETGTAPDHED TTADMKVEP
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.412760.0leaf
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306893940.0
Genevisible245873_at0.0
Expression AtlasAT1G26260-
AtGenExpressAT1G26260-
ATTED-IIAT1G26260-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems, and flowers. {ECO:0000269|PubMed:12679534}.
Functional Description ? help Back to Top
Source Description
TAIREncodes CIB5 (cryptochrome-interacting basic-helix-loop-helix). Related to CIB1 (AT4G34530). CIB5 interacts with CRY2 and forms heterodimer with CIB1 in vitro. Regulates flowering time redundantly with CIB1.
UniProtTranscriptional activator involved in cell elongation. Regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light (PubMed:24130508). {ECO:0000269|PubMed:23161888, ECO:0000269|PubMed:24130508}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G26260.3
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G75410
IntActSearch Q9C670
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G26260
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ6304830.0AJ630483.1 Arabidopsis thaliana mRNA for hypothetical protein, clone At1g26260.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001031093.10.0cryptochrome-interacting basic-helix-loop-helix 5
SwissprotQ9C6700.0BH076_ARATH; Transcription factor bHLH76
TrEMBLA0A178WLZ90.0A0A178WLZ9_ARATH; CIB5
STRINGAT1G26260.10.0(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Seki M, et al.
    Functional annotation of a full-length Arabidopsis cDNA collection.
    Science, 2002. 296(5565): p. 141-5
    [PMID:11910074]
  3. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  4. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  5. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  6. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  7. Gong W, et al.
    Genome-wide ORFeome cloning and analysis of Arabidopsis transcription factor genes.
    Plant Physiol., 2004. 135(2): p. 773-82
    [PMID:15208423]
  8. Hackbusch J,Richter K,Müller J,Salamini F,Uhrig JF
    A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins.
    Proc. Natl. Acad. Sci. U.S.A., 2005. 102(13): p. 4908-12
    [PMID:15781858]
  9. Liu H, et al.
    Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis.
    Science, 2008. 322(5907): p. 1535-9
    [PMID:18988809]
  10. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  11. Ikeda M,Fujiwara S,Mitsuda N,Ohme-Takagi M
    A triantagonistic basic helix-loop-helix system regulates cell elongation in Arabidopsis.
    Plant Cell, 2012. 24(11): p. 4483-97
    [PMID:23161888]
  12. Liu Y,Li X,Li K,Liu H,Lin C
    Multiple bHLH proteins form heterodimers to mediate CRY2-dependent regulation of flowering-time in Arabidopsis.
    PLoS Genet., 2013. 9(10): p. e1003861
    [PMID:24130508]
  13. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]