PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G18400.1
Common NameBEE1, BHLH44, EN77, F15H18.11, F15H18.16
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 260aa    MW: 29363.6 Da    PI: 6.9192
Description BR enhanced expression 1
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G18400.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH261.7e-08155202455
                  HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                  +h+ +Er RR +iN+++  L++++P +     k +  a++L + ++Y++sLq
  AT1G18400.1 155 SHSLAERVRRGKINERLRCLQDMVPGC----YKAMGMATMLDEIINYVQSLQ 202
                  8*************************8....355999*************99 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000838.01E-10149206No hitNo description
SuperFamilySSF474591.7E-16149219IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.364151201IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.4E-16151212IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000107.4E-6155202IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003538.8E-9157207IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006351Biological Processtranscription, DNA-templated
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:1902448Biological Processpositive regulation of shade avoidance
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 260 aa     Download sequence    Send to blast
MANFENLSSD FQTIAMDIYS SITQAADLNN NNSNLHFQTF HPSSTSLESL FLHHHQQQLL  60
HFPGNSPDSS NNFSSTSSFL HSDHNIVDET KKRKALLPTL SSSETSGVSD NTNVIATETG  120
SLRRGKRLKK KKEEEDEKER EVVHVRARRG QATDSHSLAE RVRRGKINER LRCLQDMVPG  180
CYKAMGMATM LDEIINYVQS LQNQVEFLSM KLTAASSFYD FNSETDAVDS MQRAKARETV  240
EMGRQTRDGS PVFHLSTWSL
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1126132RLKKKKE
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306858390.0
Genevisible261717_at0.0
Expression AtlasAT1G18400-
AtGenExpressAT1G18400-
ATTED-IIAT1G18400-
Functional Description ? help Back to Top
Source Description
UniProtPositive regulator of brassinosteroid signaling. {ECO:0000269|PubMed:12454087}.
Function -- GeneRIF ? help Back to Top
  1. These results provide new insight into the regulatory control of phenylpropanoid metabolism at low temperatures, and reveal that BEE1 and GFR act as important components of the signal transduction chain.
    [PMID: 27125220]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G18400.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by brassinosteroid, auxin, ethylene and cytokinin, and repressed by abscisic acid. Insensitive to gibberellic acid. {ECO:0000269|PubMed:12454087}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDbrassinosteroid
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G25330
IntActSearch Q8GZ13
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: No visible phenotype. Redundant with BEE2 and BEE3. {ECO:0000269|PubMed:12454087}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G18400
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK1172690.0AK117269.1 Arabidopsis thaliana At1g18400 mRNA for putative bHLH transcription factor (bHLH044), complete cds, clone: RAFL16-82-F22.
GenBankAY1382530.0AY138253.1 Arabidopsis thaliana putative bHLH transcription factor (BEE1) mRNA, complete cds.
GenBankBT0052680.0BT005268.1 Arabidopsis thaliana At1g18400 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_173276.20.0BR enhanced expression 1
SwissprotQ8GZ130.0BEE1_ARATH; Transcription factor BEE 1
TrEMBLA0A178W2570.0A0A178W257_ARATH; BEE1
STRINGAT1G18400.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM29972765
Representative plantOGRP5816313
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Seki M, et al.
    Functional annotation of a full-length Arabidopsis cDNA collection.
    Science, 2002. 296(5565): p. 141-5
    [PMID:11910074]
  3. Friedrichsen DM, et al.
    Three redundant brassinosteroid early response genes encode putative bHLH transcription factors required for normal growth.
    Genetics, 2002. 162(3): p. 1445-56
    [PMID:12454087]
  4. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  5. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  6. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  7. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  8. P
    The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling.
    Plant Physiol., 2004. 134(1): p. 101-17
    [PMID:14730066]
  9. Nemhauser JL,Mockler TC,Chory J
    Interdependency of brassinosteroid and auxin signaling in Arabidopsis.
    PLoS Biol., 2004. 2(9): p. E258
    [PMID:15328536]
  10. Yin Y, et al.
    A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis.
    Cell, 2005. 120(2): p. 249-59
    [PMID:15680330]
  11. Hannah MA,Heyer AG,Hincha DK
    A global survey of gene regulation during cold acclimation in Arabidopsis thaliana.
    PLoS Genet., 2005. 1(2): p. e26
    [PMID:16121258]
  12. Lee BH,Henderson DA,Zhu JK
    The Arabidopsis cold-responsive transcriptome and its regulation by ICE1.
    Plant Cell, 2005. 17(11): p. 3155-75
    [PMID:16214899]
  13. Gao M,Li G,Potter D,McCombie WR,Quiros CF
    Comparative analysis of methylthioalkylmalate synthase (MAM) gene family and flanking DNA sequences in Brassica oleracea and Arabidopsis thaliana.
    Plant Cell Rep., 2006. 25(6): p. 592-8
    [PMID:16432629]
  14. Li L,Jean M,Belzile F
    The impact of sequence divergence and DNA mismatch repair on homeologous recombination in Arabidopsis.
    Plant J., 2006. 45(6): p. 908-16
    [PMID:16507082]
  15. Brodersen P, et al.
    Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4.
    Plant J., 2006. 47(4): p. 532-46
    [PMID:16813576]
  16. Catala R, et al.
    The Arabidopsis E3 SUMO ligase SIZ1 regulates plant growth and drought responses.
    Plant Cell, 2007. 19(9): p. 2952-66
    [PMID:17905899]
  17. Husbands A,Bell EM,Shuai B,Smith HM,Springer PS
    LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins.
    Nucleic Acids Res., 2007. 35(19): p. 6663-71
    [PMID:17913740]
  18. Hanada K, et al.
    Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana.
    Mol. Biol. Evol., 2011. 28(1): p. 377-82
    [PMID:20736450]
  19. Poppenberger B, et al.
    CESTA, a positive regulator of brassinosteroid biosynthesis.
    EMBO J., 2011. 30(6): p. 1149-61
    [PMID:21336258]
  20. Crawford BC,Yanofsky MF
    HALF FILLED promotes reproductive tract development and fertilization efficiency in Arabidopsis thaliana.
    Development, 2011. 138(14): p. 2999-3009
    [PMID:21693516]
  21. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  22. Cifuentes-Esquivel N, et al.
    The bHLH proteins BEE and BIM positively modulate the shade avoidance syndrome in Arabidopsis seedlings.
    Plant J., 2013. 75(6): p. 989-1002
    [PMID:23763263]
  23. Petridis A,Döll S,Nichelmann L,Bilger W,Mock HP
    Arabidopsis thaliana G2-LIKE FLAVONOID REGULATOR and BRASSINOSTEROID ENHANCED EXPRESSION1 are low-temperature regulators of flavonoid accumulation.
    New Phytol., 2016. 211(3): p. 912-25
    [PMID:27125220]