PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G10480.1
Common NameT10O24.9, ZFP5
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 211aa    MW: 23590.2 Da    PI: 9.1532
Description zinc finger protein 5
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G10480.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H216.52.5e-056082123
                 EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2  1 ykCpdCgksFsrksnLkrHirtH 23
                 ++C++Cgk F ++  L  H++ H
  AT1G10480.1 60 HECQYCGKEFANSQALGGHQNAH 82
                 78******************988 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576679.64E-75887No hitNo description
Gene3DG3DSA:3.30.160.606.2E-65886IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PfamPF139123.2E-65984IPR007087Zinc finger, C2H2
PROSITE profilePS5015711.9676087IPR007087Zinc finger, C2H2
PROSITE patternPS0002806282IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007275Biological Processmulticellular organism development
GO:0009736Biological Processcytokinin-activated signaling pathway
GO:0009740Biological Processgibberellic acid mediated signaling pathway
GO:0010026Biological Processtrichome differentiation
GO:0048510Biological Processregulation of timing of transition from vegetative to reproductive phase
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000230anatomyinflorescence meristem
PO:0009005anatomyroot
PO:0009046anatomyflower
PO:0009049anatomyinflorescence
PO:0020100anatomyhypocotyl
PO:0007611developmental stagepetal differentiation and expansion stage
Sequence ? help Back to Top
Protein Sequence    Length: 211 aa     Download sequence    Send to blast
MSINPTMSRT GESSSGSSSD KTIKLFGFEL ISGSRTPEIT TAESVSSSTN TTSLTVMKRH  60
ECQYCGKEFA NSQALGGHQN AHKKERLKKK RLQLQARRAS IGYYLTNHQQ PITTSFQRQY  120
KTPSYCAFSS MHVNNDQMGV YNEDWSSRSS QINFGNNDTC QDLNEQSGEM GKLYGVRPNM  180
IQFQRDLSSR SDQMRSINSL DLHLGFAGDA A
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO425618980.0
Genevisible263208_at0.0
Expression AtlasAT1G10480-
AtGenExpressAT1G10480-
ATTED-IIAT1G10480-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Highly expressed in roots, young leaves, developing stems, branches, inflorescence meristems, floral meristems and siliques. Expressed at low levels in rosette and cauline leaves. {ECO:0000269|PubMed:21803862, ECO:0000269|PubMed:22762888}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a zinc finger protein containing only a single zinc finger.
UniProtProbable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin (GA). Acts upstream of GIS, GIS2, ZFP8 and the trichome initiation regulators GL1 and GL3 (PubMed:21803862, PubMed:22301962). Binds the promoter region of ZFP8, which may be a direct target of ZPF5 (PubMed:21803862). Is not involved in the regulation of trichome branching (PubMed:22301962). Modulates root hair initiation and elongation in response to cytokinin and ethylene signals by directly promoting expression of the CAPRICE (CPC) gene (PubMed:22762888). {ECO:0000269|PubMed:21803862, ECO:0000269|PubMed:22301962, ECO:0000269|PubMed:22762888}.
Function -- GeneRIF ? help Back to Top
  1. ZFP8 is the direct target of ZFP5 in controlling epidermal cell differentiation.
    [PMID: 21803862]
  2. show that ZFP5 encodes a protein functionally equivalent to GIS and GIS2 in controlling trichome initiation
    [PMID: 22301962]
  3. ZFP5 integrates various plant hormone cues to control root epidermal cell development in Arabidopsis.
    [PMID: 22762888]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G10480.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cytokinin and ethylene. {ECO:0000269|PubMed:22762888}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Reduced trichome production on sepals, cauline leaves, paraclades and main inflorescence stems. Reduced number and size of root hairs, due to reduced growth rate. {ECO:0000269|PubMed:21803862, ECO:0000269|PubMed:22762888}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G10480
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0070670.0AC007067.4 Genomic sequence for Arabidopsis thaliana BAC T10O24 from Chromosome 1, complete sequence.
GenBankATHZFPE0.0L39648.1 Arabidopsis thaliana zinc finger protein (ZFP5) mRNA, complete cds.
GenBankAY0863020.0AY086302.1 Arabidopsis thaliana clone 23664 mRNA, complete sequence.
GenBankBT0248400.0BT024840.1 Arabidopsis thaliana At1g10480 gene, complete cds.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_172518.11e-158zinc finger protein 5
SwissprotQ392641e-159ZFP5_ARATH; Zinc finger protein 5
TrEMBLA0A178W5E91e-157A0A178W5E9_ARATH; ZFP5
STRINGAT1G10480.11e-158(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM73252541
Representative plantOGRP1020968
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Dal Bosco C, et al.
    Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.
    J. Biol. Chem., 2004. 279(2): p. 1060-9
    [PMID:14576160]
  3. Jiao Y, et al.
    A genome-wide analysis of blue-light regulation of Arabidopsis transcription factor gene expression during seedling development.
    Plant Physiol., 2003. 133(4): p. 1480-93
    [PMID:14605227]
  4. Englbrecht CC,Schoof H,B
    Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.
    BMC Genomics, 2004. 5(1): p. 39
    [PMID:15236668]
  5. Brodersen P, et al.
    Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4.
    Plant J., 2006. 47(4): p. 532-46
    [PMID:16813576]
  6. Lee DJ, et al.
    Genome-wide expression profiling of ARABIDOPSIS RESPONSE REGULATOR 7(ARR7) overexpression in cytokinin response.
    Mol. Genet. Genomics, 2007. 277(2): p. 115-37
    [PMID:17061125]
  7. Shin R,Jez JM,Basra A,Zhang B,Schachtman DP
    14-3-3 proteins fine-tune plant nutrient metabolism.
    FEBS Lett., 2011. 585(1): p. 143-7
    [PMID:21094157]
  8. Zhou Z, et al.
    Zinc finger protein5 is required for the control of trichome initiation by acting upstream of zinc finger protein8 in Arabidopsis.
    Plant Physiol., 2011. 157(2): p. 673-82
    [PMID:21803862]
  9. Gaudinier A, et al.
    Enhanced Y1H assays for Arabidopsis.
    Nat. Methods, 2011. 8(12): p. 1053-5
    [PMID:22037706]
  10. Zhou Z,An L,Sun L,Gan Y
    ZFP5 encodes a functionally equivalent GIS protein to control trichome initiation.
    Plant Signal Behav, 2012. 7(1): p. 28-30
    [PMID:22301962]
  11. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  12. An L, et al.
    A zinc finger protein gene ZFP5 integrates phytohormone signaling to control root hair development in Arabidopsis.
    Plant J., 2012. 72(3): p. 474-90
    [PMID:22762888]
  13. Zhou Z, et al.
    Zinc Finger Protein 6 (ZFP6) regulates trichome initiation by integrating gibberellin and cytokinin signaling in Arabidopsis thaliana.
    New Phytol., 2013. 198(3): p. 699-708
    [PMID:23506479]
  14. Savage LJ,Imre KM,Hall DA,Last RL
    Analysis of essential Arabidopsis nuclear genes encoding plastid-targeted proteins.
    PLoS ONE, 2013. 8(9): p. e73291
    [PMID:24023856]
  15. Sun L, et al.
    GLABROUS INFLORESCENCE STEMS3 (GIS3) regulates trichome initiation and development in Arabidopsis.
    New Phytol., 2015. 206(1): p. 220-30
    [PMID:25640859]
  16. Yu D, et al.
    RPN1a, a subunit of the 26S proteasome, controls trichome development in Arabidopsis.
    Plant Physiol. Biochem., 2015. 88: p. 82-8
    [PMID:25676129]
  17. Kim SY,Hyoung S,So WM,Shin JS
    The novel transcription factor TRP interacts with ZFP5, a trichome initiation-related transcription factor, and negatively regulates trichome initiation through gibberellic acid signaling.
    Plant Mol. Biol., 2018. 96(3): p. 315-326
    [PMID:29335898]
  18. Tague BW,Goodman HM
    Characterization of a family of Arabidopsis zinc finger protein cDNAs.
    Plant Mol. Biol., 1995. 28(2): p. 267-79
    [PMID:7599312]