PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G10170.1
Common NameATNFXL1, F14N23.5, NFXL1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family NF-X1
Protein Properties Length: 1188aa    MW: 130716 Da    PI: 8.1239
Description NF-X-like 1
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G10170.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-NF-X123.61.1e-07390408119
     zf-NF-X1   1 CGkHkCqklCHeGpCppCp 19 
                  CG+H+C+++CH GpC+pC+
  AT1G10170.1 390 CGRHQCERTCHVGPCDPCQ 408
                  ******************6 PP

2zf-NF-X1186.4e-06454471118
     zf-NF-X1   1 CGkHkCqklCHeGpCppC 18 
                  CG+H C++ CH+GpC+ C
  AT1G10170.1 454 CGNHFCSEVCHPGPCGDC 471
                  ****************99 PP

3zf-NF-X118.35.2e-06516530418
     zf-NF-X1   4 HkCqklCHeGpCppC 18 
                  H+C++ CH G+CppC
  AT1G10170.1 516 HTCNEMCHAGDCPPC 530
                  *************** PP

4zf-NF-X118.54.4e-06611629119
     zf-NF-X1   1 CGkHkCqklCHeGpCppCp 19 
                  CG+H+C++lCH G CppC 
  AT1G10170.1 611 CGQHSCESLCHSGHCPPCL 629
                  ******************6 PP

5zf-NF-X118.44.8e-06721736116
     zf-NF-X1   1 CGkHkCqklCHeGpCp 16 
                  CG+H C ++CH+ pC+
  AT1G10170.1 721 CGMHACARTCHPEPCD 736
                  ***************8 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF578505.65E-6212283No hitNo description
PROSITE profilePS500168.956220281IPR019787Zinc finger, PHD-finger
PROSITE patternPS013590223278IPR019786Zinc finger, PHD-type, conserved site
PROSITE profilePS500899.465223279IPR001841Zinc finger, RING-type
CDDcd060081.50E-6312373No hitNo description
SMARTSM004380.023335353IPR000967Zinc finger, NF-X1-type
PfamPF014228.9337352IPR000967Zinc finger, NF-X1-type
CDDcd060084.39E-13380428No hitNo description
SMARTSM004385.3E-5390409IPR000967Zinc finger, NF-X1-type
PfamPF014229.2E-6390407IPR000967Zinc finger, NF-X1-type
CDDcd060083.21E-8448489No hitNo description
SMARTSM004382.6E-5454473IPR000967Zinc finger, NF-X1-type
PfamPF014227.6E-5454471IPR000967Zinc finger, NF-X1-type
CDDcd060083.29E-13503550No hitNo description
SMARTSM004382.3E-5513532IPR000967Zinc finger, NF-X1-type
PfamPF014225.5E-4515530IPR000967Zinc finger, NF-X1-type
CDDcd060086.60E-5562622No hitNo description
SMARTSM00438170572607IPR000967Zinc finger, NF-X1-type
PfamPF0142220572583IPR000967Zinc finger, NF-X1-type
CDDcd060086.34E-9601653No hitNo description
SMARTSM004382.0E-4611630IPR000967Zinc finger, NF-X1-type
PfamPF014221.1E-4611628IPR000967Zinc finger, NF-X1-type
CDDcd060081.17E-6658705No hitNo description
SMARTSM004380.034668686IPR000967Zinc finger, NF-X1-type
PfamPF0142225675685IPR000967Zinc finger, NF-X1-type
SMARTSM004384.7E-4721751IPR000967Zinc finger, NF-X1-type
PfamPF014220.0074721736IPR000967Zinc finger, NF-X1-type
CDDcd060083.02E-4749798No hitNo description
PfamPF014220.043753779IPR000967Zinc finger, NF-X1-type
SMARTSM004380.021760781IPR000967Zinc finger, NF-X1-type
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000122Biological Processnegative regulation of transcription from RNA polymerase II promoter
GO:0009642Biological Processresponse to light intensity
GO:0009651Biological Processresponse to salt stress
GO:0009697Biological Processsalicylic acid biosynthetic process
GO:0010188Biological Processresponse to microbial phytotoxin
GO:0010310Biological Processregulation of hydrogen peroxide metabolic process
GO:0016567Biological Processprotein ubiquitination
GO:0042742Biological Processdefense response to bacterium
GO:0005634Cellular Componentnucleus
GO:0000977Molecular FunctionRNA polymerase II regulatory region sequence-specific DNA binding
GO:0001078Molecular Functiontranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0005515Molecular Functionprotein binding
GO:0008270Molecular Functionzinc ion binding
GO:0016874Molecular Functionligase activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000014anatomyrosette leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009001anatomyfruit
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009049anatomyinflorescence
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025195anatomypollen tube cell
PO:0025281anatomypollen
PO:0001016developmental stageL mature pollen stage
PO:0001017developmental stageM germinated pollen stage
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 1188 aa     Download sequence    Send to blast
MSFQVRRDRS DDRSHRFNHQ QTWIPRNSST SSVVVNEPLL PPNTDRNSET LDAGSASRPV  60
YLQRQHNASG PPSYNHHQRS SNIGPPPPNQ HRRYNAPDNQ HQRSDNIGPP QPNQHRRYNA  120
PDNQHQRSDN SGPPQPYRHR RNNAPENQHQ RSDNIGPPPP NRQRRNNASG TLPDNRQRVA  180
SRTRPVNQGK RVAKEENVVL TDPNLPQLVQ ELQEKLVKSS IECMICYDKV GRSANIWSCS  240
SCYSIFHINC IKRWARAPTS VDLLAEKNQG DNWRCPGCQS VQLTSSKEIS YRCFCGKRRD  300
PPSDPYLTPH SCGEPCGKPL EKEFAPAETT EEDLCPHVCV LQCHPGPCPP CKAFAPPRSC  360
PCGKKMVTTR CSERRSDLVC GQRCDKLLSC GRHQCERTCH VGPCDPCQVL VNATCFCKKK  420
VETVICGDMN VKGELKAEDG VYSCSFNCGK PLGCGNHFCS EVCHPGPCGD CDLLPSRVKT  480
CYCGNTRLEE QIRQSCLDPI PSCSNVCRKL LPCRLHTCNE MCHAGDCPPC LVQVNQKCRC  540
GSTSRAVECY ITTSSEAEKF VCAKPCGRKK NCGRHRCSER CCPLLNGKKN DLSGDWDPHV  600
CQIPCQKKLR CGQHSCESLC HSGHCPPCLE MIFTDLTCAC GRTSIPPPLS CGTPVPSCQL  660
PCPIPQPCGH SDTHGCHFGD CPPCSTPVEK KCVGGHVVLR NIPCGLKDIR CTKICGKTRR  720
CGMHACARTC HPEPCDSFNE SEAGMRVTCR QKCGAPRTDC RHTCAALCHP SAPCPDLRCE  780
FSVTITCSCG RITATVPCDA GGRSANGSNV YCAAYDEASV LQKLPAPLQP VESSGNRIPL  840
GQRKLSCDDE CAKLERKRVL QDAFDITPPN LEALHFSENS AMTEIISDLY RRDPKWVLAV  900
EERCKFLVLG KARGSTSALK VHIFCPMQKD KRDTVRLIAE RWKLGVSNAG WEPKRFTVVH  960
VTAKSKPPTR IIGARGGAIS IGGPHPPFYD SLVDMDPGLV VSFLDLPREA NISALVLRFG  1020
GECELVWLND KNALAVFHDH ARAATAMRRL EHGSVYHGAV VVQSGGQSPS LNNVWGKLPG  1080
SSAWDVDKGN PWRRAVIQES DDSWGAEDSP IGGSSTDAQA SALRSAKSNS PIVTSVNRWS  1140
VLEPKKASTS TLEPIAQIEE SSSSKTTGKQ PVEGSGEEVV DDWEKVCE
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.253900.0bud| flower| root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306815860.0
Genevisible264460_at0.0
Expression AtlasAT1G10170-
AtGenExpressAT1G10170-
ATTED-IIAT1G10170-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in seedlings, roots, stems, leaves, buds, flowers and siliques. {ECO:0000269|PubMed:16905136}.
Functional Description ? help Back to Top
Source Description
TAIREncodes AtNFXL1, a homologue of the putative human transcription repressor NF-X1. Functions as a negative regulator of the trichothecene phytotoxin-induced defense response.
UniProtMediates E2-dependent ubiquitination (By similarity). Confers resistance to osmotic stress such as high salinity. Promotes H(2)O(2) production. Negative regulator of some defense-related genes via an salicylic acid (SA)-dependent signaling pathway. Confers susceptibility to the compatible phytopathogen Pseudomonas syringae pv. tomato strain DC3000 (Pst DC3000). Mediates resistance to type A trichothecenes (phytotoxins produced by phytopathogenic fungi). {ECO:0000250, ECO:0000269|PubMed:16905136, ECO:0000269|PubMed:18069941, ECO:0000269|PubMed:19704430}.
Function -- GeneRIF ? help Back to Top
  1. Data suggest that the Arabidopsis NFXL1 and NFXL2 zinc finger proteins likely are part of regulatory mechanisms, which protect major processes such as photosynthesis.
    [PMID: 16905136]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G10170.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By brassinosteroids, osmotic stress and high salinity. Accumulates in response to SA, ethylene, methyl jasmonate (MeJA), flagellin (e.g. flg22), and type A trichothecenes such as T-2 toxin and diacetoxyscirpenol (DAS), but not in response to type B trichothecenes such as deoxynivalenol (DON). {ECO:0000269|PubMed:16905136, ECO:0000269|PubMed:18069941, ECO:0000269|PubMed:19704430}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT1G74710(R), AT2G14610(R), AT4G39030(R)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDsalicylic acid
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Impaired growth and survival under salt stress. Reduced H(2)O(2) production. Hypersensitivity to T-2 toxin and DAS (but not to DON), accompanied by enhanced SA accumulation and several plant defense gene induction. Less susceptible to Pst DC3000. {ECO:0000269|PubMed:16905136, ECO:0000269|PubMed:18069941, ECO:0000269|PubMed:19704430}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G10170
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0054890.0AC005489.1 Genomic sequence for Arabidopsis thaliana BAC F14N23 from Chromosome 1, complete sequence.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_172488.10.0NF-X1-type zinc finger protein NFXL1
SwissprotQ9SY590.0NFXL1_ARATH; NF-X1-type zinc finger protein NFXL1
TrEMBLD7KKM70.0D7KKM7_ARALL; NF-X1 type zinc finger family protein
STRINGAT1G10170.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP39501420
MalvidsOGEM59552647
Publications ? help Back to Top
  1. Kosarev P,Mayer KF,Hardtke CS
    Evaluation and classification of RING-finger domains encoded by the Arabidopsis genome.
    Genome Biol., 2002. 3(4): p. RESEARCH0016
    [PMID:11983057]
  2. Kreps JA, et al.
    Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress.
    Plant Physiol., 2002. 130(4): p. 2129-41
    [PMID:12481097]
  3. Lee BH,Henderson DA,Zhu JK
    The Arabidopsis cold-responsive transcriptome and its regulation by ICE1.
    Plant Cell, 2005. 17(11): p. 3155-75
    [PMID:16214899]
  4. Ma S,Gong Q,Bohnert HJ
    Dissecting salt stress pathways.
    J. Exp. Bot., 2006. 57(5): p. 1097-107
    [PMID:16510518]
  5. Lisso J,Altmann T,Müssig C
    The AtNFXL1 gene encodes a NF-X1 type zinc finger protein required for growth under salt stress.
    FEBS Lett., 2006. 580(20): p. 4851-6
    [PMID:16905136]
  6. Larkindale J,Vierling E
    Core genome responses involved in acclimation to high temperature.
    Plant Physiol., 2008. 146(2): p. 748-61
    [PMID:18055584]
  7. Asano T, et al.
    AtNFXL1, an Arabidopsis homologue of the human transcription factor NF-X1, functions as a negative regulator of the trichothecene phytotoxin-induced defense response.
    Plant J., 2008. 53(3): p. 450-64
    [PMID:18069941]
  8. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  9. Wang Y, et al.
    Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
    Plant Physiol., 2008. 148(3): p. 1201-11
    [PMID:18775970]
  10. Asano T, et al.
    The AtNFXL1 gene functions as a signaling component of the type A trichothecene-dependent response.
    Plant Signal Behav, 2008. 3(11): p. 991-992
    [PMID:19704430]
  11. M
    Structure and putative function of NFX1-like proteins in plants.
    Plant Biol (Stuttg), 2010. 12(3): p. 381-94
    [PMID:20522174]
  12. Lisso J,Schr
    NFX1-LIKE2 (NFXL2) suppresses abscisic acid accumulation and stomatal closure in Arabidopsis thaliana.
    PLoS ONE, 2011. 6(11): p. e26982
    [PMID:22073231]
  13. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]