PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_9633_f_1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family WRKY
Protein Properties Length: 358aa    MW: 40116.4 Da    PI: 5.2591
Description WRKY family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_9633_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRKY93.41.7e-29131190258
                    --SS-EEEEEEE--TT-SS-EEEEEE-ST...T---EEEEEE-SSSTTEEEEEEES--SS CS
           WRKY   2 dDgynWrKYGqKevkgsefprsYYrCtsa...gCpvkkkversaedpkvveitYegeHnh 58 
                    +Dgy+WrKYGqK++ g+++prsYYrCt++   +C+++k+v+rs+edp+++eitY+g+H++
  Neem_9633_f_1 131 EDGYSWRKYGQKDILGAKYPRSYYRCTYRntqNCWATKQVQRSDEDPTIFEITYRGKHTC 190
                    8***************************98899*************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5081122.492125188IPR003657WRKY domain
Gene3DG3DSA:2.20.25.801.1E-28126190IPR003657WRKY domain
SuperFamilySSF1182901.27E-25129190IPR003657WRKY domain
SMARTSM007747.2E-40130192IPR003657WRKY domain
PfamPF031068.4E-27131190IPR003657WRKY domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009751Biological Processresponse to salicylic acid
GO:0009816Biological Processdefense response to bacterium, incompatible interaction
GO:0010150Biological Processleaf senescence
GO:0010193Biological Processresponse to ozone
GO:0010200Biological Processresponse to chitin
GO:0031347Biological Processregulation of defense response
GO:0042542Biological Processresponse to hydrogen peroxide
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0009507Cellular Componentchloroplast
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 358 aa     Download sequence    Send to blast
MEPGWSWEQK TLISELIEGM EMAKQLRVNL VAASSAETSE ALVQRILSSY EKALLILKWS  60
GSMGQAQGVG ATSGVPESPI SINGSPRSED FDAGFKDNQD QQDSSKKRKT MPRWTDKVKV  120
NFETGLEGPL EDGYSWRKYG QKDILGAKYP RSYYRCTYRN TQNCWATKQV QRSDEDPTIF  180
EITYRGKHTC FHGSQAVPQP ASPEKHEQRL NHHNNNHQLK QSQEIISNSR AGLGMNNECL  240
DNKEIASPFS FPSTPFGCMK GNDQCFPPLM LDENNFSGGF SSSFIPPSQA ESNYYFISPN  300
RMNNFGDVHN LHRSESDLPE LQSANNSAAN SPILNLDFSL DPAEIDPNFP FDPAGFSF
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
6ir8_A1e-19130190868OsWRKY45
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:20409006). May regulate the early events of leaf senescence (PubMed:17369373, PubMed:20409006). Negatively regulates the expression of ESR/ESP (PubMed:20409006). Together with WRKY46 and WRKY70, promotes resistance to P.syringae, probably by enhancing salicylic acid (SA)- dependent genes. Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1.2 (PubMed:22325892). {ECO:0000269|PubMed:17369373, ECO:0000269|PubMed:20409006, ECO:0000269|PubMed:22325892}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By salicylic acid (SA) (PubMed:22268143, PubMed:22325892). Strong accumulation during leaf senescence (PubMed:22268143). Down-regulated by jasmonate. Triggered by P.syringae (PubMed:22325892). {ECO:0000269|PubMed:11449049, ECO:0000269|PubMed:11506370, ECO:0000269|PubMed:17369373, ECO:0000269|PubMed:22268143, ECO:0000269|PubMed:22325892}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006439376.10.0probable WRKY transcription factor 53
SwissprotQ9SUP61e-71WRK53_ARATH; Probable WRKY transcription factor 53
TrEMBLA0A067GMD40.0A0A067GMD4_CITSI; Uncharacterized protein
STRINGXP_006439376.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM19332783
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G23810.18e-74WRKY family protein
Publications ? help Back to Top
  1. Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P
    An extracellular subtilase switch for immune priming in Arabidopsis.
    PLoS Pathog., 2013. 9(6): p. e1003445
    [PMID:23818851]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Singh V,Roy S,Singh D,Nandi AK
    Arabidopsis flowering locus D influences systemic-acquired-resistance- induced expression and histone modifications of WRKY genes.
    J. Biosci., 2014. 39(1): p. 119-26
    [PMID:24499796]
  4. Zhang H, et al.
    Arabidopsis AtERF15 positively regulates immunity against Pseudomonas syringae pv. tomato DC3000 and Botrytis cinerea.
    Front Plant Sci, 2015. 6: p. 686
    [PMID:26388886]
  5. Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P
    Correction: An Extracellular Subtilase Switch for Immune Priming in Arabidopsis.
    PLoS Pathog., 2016. 12(11): p. e1006003
    [PMID:27806116]
  6. Chen X, et al.
    POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis.
    Elife, 2017.
    [PMID:27873573]
  7. Nie P, et al.
    Induced Systemic Resistance against Botrytis cinerea by Bacillus cereus AR156 through a JA/ET- and NPR1-Dependent Signaling Pathway and Activates PAMP-Triggered Immunity in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 238
    [PMID:28293243]
  8. Ren Y,Li Y,Jiang Y,Wu B,Miao Y
    Phosphorylation of WHIRLY1 by CIPK14 Shifts Its Localization and Dual Functions in Arabidopsis.
    Mol Plant, 2017. 10(5): p. 749-763
    [PMID:28412544]
  9. Sarkar S, et al.
    Interaction of Arabidopsis TGA3 and WRKY53 transcription factors on Cestrum yellow leaf curling virus (CmYLCV) promoter mediates salicylic acid-dependent gene expression in planta.
    Planta, 2018. 247(1): p. 181-199
    [PMID:28913593]
  10. Crespo-Salvador Ó,Escamilla-Aguilar M,López-Cruz J,López-Rodas G,González-Bosch C
    Determination of histone epigenetic marks in Arabidopsis and tomato genes in the early response to Botrytis cinerea.
    Plant Cell Rep., 2018. 37(1): p. 153-166
    [PMID:29119291]
  11. Yuan N, et al.
    STRESS INDUCED FACTOR 2, a Leucine-Rich Repeat Kinase Regulates Basal Plant Pathogen Defense.
    Plant Physiol., 2018. 176(4): p. 3062-3080
    [PMID:29463771]