PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_10258_f_1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family WRKY
Protein Properties Length: 549aa    MW: 59884.2 Da    PI: 7.563
Description WRKY family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_10258_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRKY96.61.7e-30298356259
                     --SS-EEEEEEE--TT-SS-EEEEEE-ST.T---EEEEEE-SSSTTEEEEEEES--SS- CS
            WRKY   2 dDgynWrKYGqKevkgsefprsYYrCtsa.gCpvkkkversaedpkvveitYegeHnhe 59 
                     +Dg++WrKYGqK+ kg+++pr+YYrCt+a gCpv+k+v+r+++d +++++tYeg+Hnh+
  Neem_10258_f_1 298 SDGCQWRKYGQKMAKGNPCPRAYYRCTMAsGCPVRKQVQRCSQDRTILVTTYEGNHNHP 356
                     7***************************99****************************7 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:2.20.25.801.5E-33282358IPR003657WRKY domain
SuperFamilySSF1182901.83E-27290358IPR003657WRKY domain
PROSITE profilePS5081130.217292358IPR003657WRKY domain
SMARTSM007746.6E-36297357IPR003657WRKY domain
PfamPF031062.0E-26299356IPR003657WRKY domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 549 aa     Download sequence    Send to blast
MDDRLLGLSI GTDDPSKSCF FHPIFSKIPV NNTTTAACKH DIMGRVDSDR ILINGGDDRV  60
SALQTNISEK RVVNEMNFFA DDVKDKLASD NQETSSVDHV KKESTSTVLD AGEQGIKLDI  120
NTGLNLSTPN SSSEKFNIEK TSKNIEYKPQ ENELAVLQAD LNKMNVENQR LRGLLNQVNS  180
DYRALQMHLL TFMQRQQIRR PGNIPVHEMI NGGKVAVARQ FMDLGQAAAA EKDDQLSHSS  240
SEEARQDQDA AQSAAGWCSN KVPRFSSSRD VENASQTMSM IRKARVSVRA RSEASMISDG  300
CQWRKYGQKM AKGNPCPRAY YRCTMASGCP VRKQVQRCSQ DRTILVTTYE GNHNHPLPPA  360
AMAMASTTSA AVSMLLSGSM PSADGIVNAD FLTKSSLPFS PSLASLSASA PFPTITLDLT  420
HNPIPNPSQF QRQLCQFHFP SPNNLPQNFV TMPQVFAHAV INNQSSFMGL LNSMGLEQPQ  480
SAQNLMPAND TISAATAAAI TADPSFTAAL VAAITSVIGN VHQNQNGNSN NNTTTRNSSD  540
KIEHMKNSL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2ayd_A7e-24284360176WRKY transcription factor 1
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in the control of processes related to senescence and pathogen defense (PubMed:12000796). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:12000796). Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes (PubMed:12000796). Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression (PubMed:25733771). {ECO:0000269|PubMed:12000796, ECO:0000269|PubMed:25733771}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By salicylic acid, ethylene, jasmonic acid, pathogens, wounding and strongly during leaf senescence. {ECO:0000269|PubMed:11449049, ECO:0000269|PubMed:11722756}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKF0310692e-31KF031069.1 Gossypium hirsutum WRKY transcription factor 1 (WRKY1) mRNA, complete cds.
GenBankKF6698242e-31KF669824.1 Gossypium hirsutum WRKY transcription factor 16 (WRKY16) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006452416.21e-173probable WRKY transcription factor 31
SwissprotQ9C5191e-106WRKY6_ARATH; WRKY transcription factor 6
TrEMBLA0A2H5P2861e-173A0A2H5P286_CITUN; Uncharacterized protein
STRINGXP_006475034.11e-171(Citrus sinensis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM2557533
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G62300.11e-75WRKY family protein
Publications ? help Back to Top
  1. Zhou F, et al.
    High humidity suppresses ssi4-mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression.
    Plant J., 2004. 39(6): p. 920-32
    [PMID:15341634]
  2. Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P
    An extracellular subtilase switch for immune priming in Arabidopsis.
    PLoS Pathog., 2013. 9(6): p. e1003445
    [PMID:23818851]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Singh V,Roy S,Singh D,Nandi AK
    Arabidopsis flowering locus D influences systemic-acquired-resistance- induced expression and histone modifications of WRKY genes.
    J. Biosci., 2014. 39(1): p. 119-26
    [PMID:24499796]
  5. Ali MA,Wieczorek K,Kreil DP,Bohlmann H
    The beet cyst nematode Heterodera schachtii modulates the expression of WRKY transcription factors in syncytia to favour its development in Arabidopsis roots.
    PLoS ONE, 2014. 9(7): p. e102360
    [PMID:25033038]
  6. Chai J,Liu J,Zhou J,Xing D
    Mitogen-activated protein kinase 6 regulates NPR1 gene expression and activation during leaf senescence induced by salicylic acid.
    J. Exp. Bot., 2014. 65(22): p. 6513-28
    [PMID:25210078]
  7. Vermeirssen V,De Clercq I,Van Parys T,Van Breusegem F,Van de Peer Y
    Arabidopsis ensemble reverse-engineered gene regulatory network discloses interconnected transcription factors in oxidative stress.
    Plant Cell, 2014. 26(12): p. 4656-79
    [PMID:25549671]
  8. Xiao D, et al.
    SENESCENCE-SUPPRESSED PROTEIN PHOSPHATASE Directly Interacts with the Cytoplasmic Domain of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE and Negatively Regulates Leaf Senescence in Arabidopsis.
    Plant Physiol., 2015. 169(2): p. 1275-91
    [PMID:26304848]
  9. Bakshi M, et al.
    WRKY6 restricts Piriformospora indica-stimulated and phosphate-induced root development in Arabidopsis.
    BMC Plant Biol., 2015. 15: p. 305
    [PMID:26718529]
  10. Huang Y,Feng CZ,Ye Q,Wu WH,Chen YF
    Arabidopsis WRKY6 Transcription Factor Acts as a Positive Regulator of Abscisic Acid Signaling during Seed Germination and Early Seedling Development.
    PLoS Genet., 2016. 12(2): p. e1005833
    [PMID:26829043]
  11. Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P
    Correction: An Extracellular Subtilase Switch for Immune Priming in Arabidopsis.
    PLoS Pathog., 2016. 12(11): p. e1006003
    [PMID:27806116]
  12. Li H, et al.
    BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis.
    Mol Plant, 2017. 10(4): p. 545-559
    [PMID:28089951]
  13. Stetter MG,Benz M,Ludewig U
    Increased root hair density by loss of WRKY6 in Arabidopsis thaliana.
    PeerJ, 2017. 5: p. e2891
    [PMID:28149680]
  14. Zhou X, et al.
    StMYB44 negatively regulates phosphate transport by suppressing expression of PHOSPHATE1 in potato.
    J. Exp. Bot., 2017. 68(5): p. 1265-1281
    [PMID:28338870]
  15. Bakshi M, et al.
    Piriformospora indica Reprograms Gene Expression in Arabidopsis Phosphate Metabolism Mutants But Does Not Compensate for Phosphate Limitation.
    Front Microbiol, 2017. 8: p. 1262
    [PMID:28747898]
  16. Zhang Y, et al.
    DELLA proteins negatively regulate dark-induced senescence and chlorophyll degradation in Arabidopsis through interaction with the transcription factor WRKY6.
    Plant Cell Rep., 2018. 37(7): p. 981-992
    [PMID:29574486]